Utah倾斜电极阵列神经刺激对截肢者多种皮肤和本体感觉手知觉的区分
Discrimination Among Multiple Cutaneous and Proprioceptive Hand Percepts Evoked by Nerve Stimulation with Utah Slanted Electrode Arrays in Human Amputees
摘要：
目的：本文的目的是证明恢复的手的感觉与不同的位置，质量和强度，在人类截肢者的残余传入纤维的微电极刺激诱发的功能辨别。研究方法：我们将犹他州倾斜电极阵列（USEA）植入三名经桡截肢者的正中和尺骨残臂神经中，并通过不同的电极和不同的频率提供刺激，以在缺失的手上产生不同的位置，质量和强度的感觉。进行了盲辨试验，以确定受试者在这些恢复的感觉中的辨别能力。结果如下：在盲法试验中，受试者在不同皮肤和本体感受位置、质量和强度的恢复感觉知觉之间进行辨别，包括在多达10种不同位置-强度组合之间进行辨别（15/30成功，p < 0.0005）。通过电极选择，神经内刺激部位的变化能够区分多达5个位置和质量（35/35成功，p < 0.0001）。刺激频率的变化使得能够区分相同位置处的4种不同强度（13/20成功，p < 0.005）。一名受试者区分了两个不同USEA电极的同时、交替和隔离刺激，这可能是多传感器闭环假体使用期间所需的（20/25成功，p < 0.001）。结论：USEA刺激能够编码具有不同位置、质量和强度的多种功能可辨别的感觉。重要性：这些感知提供了可能丰富的感官反馈源，其可以在多传感器闭环假体使用期间增强性能和实施例。
英文摘要：
Objective: This paper aims to demonstrate functional discriminability among restored hand sensations with different locations, qualities, and intensities that are evoked by microelectrode stimulation of residual afferent fibers in human amputees. Methods: We implanted a Utah Slanted Electrode Array (USEA) in the median and ulnar residual arm nerves of three transradial amputees and delivered stimulation via different electrodes and at different frequencies to produce various locations, qualities, and intensities of sensation on the missing hand. Blind discrimination trials were performed to determine how well subjects could discriminate among these restored sensations. Results: Subjects discriminated among restored sensory percepts with varying cutaneous and proprioceptive locations, qualities, and intensities in blind trials, including discrimination among up to 10 different location-intensity combinations (15/30 successes, p < 0.0005). Variations in the site of stimulation within the nerve, via electrode selection, enabled discrimination among up to 5 locations and qualities (35/35 successes, p < 0.0001). Variations in the stimulation frequency enabled discrimination among 4 different intensities at the same location (13/20 successes, p < 0.005). One subject discriminated among simultaneous, alternating, and isolated stimulation of two different USEA electrodes, as may be desired during multi-sensor closed-loop prosthesis use (20/25 successes, p < 0.001). Conclusion: USEA stimulation enables encoding of a diversity of functionally discriminable sensations with different locations, qualities, and intensities. Significance: These percepts provide a potentially rich source of sensory feedback that may enhance performance and embodiment during multi-sensor, closed-loop prosthesis use.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
