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arXiv 2003.00751q-bio.MNq-bio.SC
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调节干扰素的产生作为COVID-19治疗的潜在策略

Regulation of interferon production as a potential strategy for COVID-19 treatment

Xiaobing Deng, Xiaoyu Yu, Jianfeng Pei

摘要:

调节细胞因子的上游产生可能是治疗COVID-19的一个有前途的策略。我们建议更多地关注COVID-19中IFN-I产生的失调,并将cGAS、ALK和STING视为预防细胞因子风暴的潜在治疗靶点。苏拉明和ALK抑制剂等获批药物值得进行临床试验。

英文摘要:

Regulating the upstream of the cytokines production could be a promising strategy to the treatment of COVID-19. We suggest to pay more attention to the dysregulated IFN-I production in COVID-19 and to considerate cGAS, ALK and STING as potential therapeutic targets preventing cytokine storm. Approved drugs like suramin and ALK inhibitors are worthy of clinical trials.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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