基于扩散器的计算成像眼底镜
Diffuser-based computational imaging funduscope
摘要：
获得眼科护理的机会少是一个重大的全球性挑战，可以通过低成本、便携式和易于使用的诊断技术来改善。基于漫射器的成像具有实现廉价、紧凑的光学系统的潜力，该光学系统可以在散焦误差的范围内重建物体的聚焦图像。在这里，我们提出了一种基于扩散器的计算眼底镜，重建模型眼的重要临床特征。与现有的漫射成像器架构相比，我们的系统具有无限共轭的设计，通过中继目镜上的扩散。这提供了跨越宽视场（FOV）的平移不变性和跨越扩展深度范围的不变放大率。实验上，我们证明眼底图像重建超过33 $^{\circ}$ FOV和鲁棒性$\pm$ 4D屈光不正使用一个恒定的点扩散函数。结合基于漫射器的波前传感，该技术可以通过单个漫射器传感器实现组合的眼像差测量和眼底镜筛查。
英文摘要：
Poor access to eye care is a major global challenge that could be ameliorated by low-cost, portable, and easy-to-use diagnostic technologies. Diffuser-based imaging has the potential to enable inexpensive, compact optical systems that can reconstruct a focused image of an object over a range of defocus errors. Here, we present a diffuser-based computational funduscope that reconstructs important clinical features of a model eye. Compared to existing diffuser-imager architectures, our system features an infinite-conjugate design by relaying the ocular lens onto the diffuser. This offers shift-invariance across a wide field-of-view (FOV) and an invariant magnification across an extended depth range. Experimentally, we demonstrate fundus image reconstruction over a 33$^{\circ}$ FOV and robustness to $\pm$4D refractive error using a constant point-spread-function. Combined with diffuser-based wavefront sensing, this technology could enable combined ocular aberrometry and funduscopic screening through a single diffuser sensor.
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