We consider estimation of a total causal effect from observational data via covariate adjustment. Ideally, adjustment sets are selected based on a given causal graph, reflecting knowledge of the underlying causal structure. Valid adjustment sets are, however, not unique. Recent research has introduced a graphical criterion for an 'optimal' valid adjustment set (O-set). For a given graph, adjustment by the O-set yields the smallest asymptotic variance compared to other adjustment sets in certain parametric and non-parametric models. In this paper, we provide three new results on the O-set. First, we give a novel, more intuitive graphical characterisation: We show that the O-set is the parent set of the outcome node(s) in a suitable latent projection graph, which we call the forbidden projection. An important property is that the forbidden projection preserves all information relevant to total causal effect estimation via covariate adjustment, making it a useful methodological tool in its own right. Second, we extend the existing IDA algorithm to use the O-set, and argue that the algorithm remains semi-local. This is implemented in the R-package pcalg. Third, we present assumptions under which the O-set can be viewed as the target set of popular non-graphical variable selection algorithms such as stepwise backward selection.
Covariate adjustment is a commonly used method for total causal effect estimation. In recent years, graphical criteria have been developed to identify all valid adjustment sets, that is, all covariate sets that can be used for this purpose. Different valid adjustment sets typically provide total effect estimates of varying accuracies. Restricting ourselves to causal linear models, we introduce a graphical criterion to compare the asymptotic variances provided by certain valid adjustment sets. We employ this result to develop two further graphical tools. First, we introduce a simple variance re…
Covariate adjustment is a widely used approach to estimate total causal effects from observational data. Several graphical criteria have been developed in recent years to identify valid covariates for adjustment from graphical causal models. These criteria can handle multiple causes, latent confounding, or partial knowledge of the causal structure; however, their diversity is confusing and some of them are only sufficient, but not necessary. In this paper, we present a criterion that is necessary and sufficient for four different classes of graphical causal models: directed acyclic graphs (DAG…
Universidad Torcuato Di Tella（托尔夸托·迪·特利亚大学）；CONICET（阿根廷国家科学与技术研究理事会）；Harvard T. H. Chan School of Public Health（哈佛陈曾熙公共卫生学院）
The method of covariate adjustment is often used for estimation of population average treatment effects in observational studies. Graphical rules for determining all valid covariate adjustment sets from an assumed causal graphical model are well known. Restricting attention to causal linear models, a recent article derived two novel graphical criteria: one to compare the asymptotic variance of linear regression treatment effect estimators that control for certain distinct adjustment sets and another to identify the optimal adjustment set that yields the least squares treatment effect estimator…
Confounding bias, missing data, and selection bias are three common obstacles to valid causal inference in the data sciences. Covariate adjustment is the most pervasive technique for recovering casual effects from confounding bias. In this paper, we introduce a covariate adjustment formulation for controlling confounding bias in the presence of missing-not-at-random data and develop a necessary and sufficient condition for recovering causal effects using the adjustment. We also introduce an adjustment formulation for controlling both confounding and selection biases in the presence of missing …
We develop finite-population asymptotic theory for covariate adjustment in randomization-based causal inference for 2K factorial designs. In particular, we confirm that both the unadjusted and covariate-adjusted estimators of the factorial effects are asymptotically normal, and the latter is more precise than the former.
Adjusting for covariates is a well established method to estimate the total causal effect of an exposure variable on an outcome of interest. Depending on the causal structure of the mechanism under study there may be different adjustment sets, equally valid from a theoretical perspective, leading to identical causal effects. However, in practice, with finite data, estimators built on different sets may display different precision. To investigate the extent of this variability we consider the simplest non-trivial non-linear model of a v-structure on three nodes for binary data. We explicitly co…
Identifying effects of actions (treatments) on outcome variables from observational data and causal assumptions is a fundamental problem in causal inference. This identification is made difficult by the presence of confounders which can be related to both treatment and outcome variables. Confounders are often handled, both in theory and in practice, by adjusting for covariates, in other words considering outcomes conditioned on treatment and covariate values, weighed by probability of observing those covariate values. In this paper, we give a complete graphical criterion for covariate adjustme…
The purpose of this work is to improve the efficiency in estimating the average causal effect (ACE) on the survival scale where right-censoring exists and high-dimensional covariate information is available. We propose new estimators using regularized survival regression and survival random forests (SRF) to make the adjustment for the high dimensional covariates to improve efficiency. We study the behavior of the adjusted estimator under mild assumptions and show theoretical guarantees that the proposed estimators are more efficient than the unadjusted ones asymptotically when using SRF for ad…
Statistical causal inference from observational studies often requires adjustment for a possibly multi-dimensional variable, where dimension reduction is crucial. The propensity score, first introduced by Rosenbaum and Rubin, is a popular approach to such reduction. We address causal inference within Dawid's decision-theoretic framework, where it is essential to pay attention to sufficient covariates and their properties. We examine the role of a propensity variable in a normal linear model. We investigate both population-based and sample-based linear regressions, with adjustments for a multiv…
We study Bayesian approaches to causal inference via propensity score regression. Much of the Bayesian literature on propensity score methods have relied on approaches that cannot be viewed as fully Bayesian in the context of conventional `likelihood times prior' posterior inference; in addition, most methods rely on parametric and distributional assumptions, and presumed correct specification. We emphasize that causal inference is typically carried out in settings of mis-specification, and develop strategies for fully Bayesian inference that reflect this. We focus on methods based on decision…
Adjustment Identification Distance: A gadjid for Causal Structure Learning
School of Mathematics and Statistics, University College Dublin（都柏林大学学院数学与统计学院）；Pioneer Centre for AI, University of Copenhagen（哥本哈根大学人工智能先锋中心）；Department of Mathematical Sciences, University of Copenhagen（哥本哈根大学数学科学系）
In the causal adjustment setting, variable selection techniques based on either the outcome or treatment allocation model can result in the omission of confounders or the inclusion of spurious variables in the propensity score. We propose a variable selection method based on a penalized likelihood which considers the response and treatment assignment models simultaneously. The proposed method facilitates confounder selection in high-dimensional settings. We show that under some conditions our method attains the oracle property. The selected variables are used to form a double robust regression…
Estimating causal effects from observational data is not always possible due to confounding. Identifying a set of appropriate covariates (adjustment set) and adjusting for their influence can remove confounding bias; however, such a set is typically not identifiable from observational data alone. Experimental data do not have confounding bias, but are typically limited in sample size and can therefore yield imprecise estimates. Furthermore, experimental data often include a limited set of covariates, and therefore provide limited insight into the causal structure of the underlying system. In t…
Under the Neyman causal model, it is well-known that OLS with treatment-by-covariate interactions cannot harm asymptotic precision of estimated treatment effects in completely randomized experiments. But do such guarantees extend to experiments with more complex designs? This paper proposes a general framework for addressing this question and defines a class of generalized regression estimators that are applicable to experiments of any design. The class subsumes common estimators (e.g., OLS). Within that class, two novel estimators are proposed that are applicable to arbitrary designs and asym…
When investigators seek to estimate causal effects, they often assume that selection into treatment is based only on observed covariates. Under this identification strategy, analysts must adjust for observed confounders. While basic regression models have long been the dominant method of statistical adjustment, more robust methods based on matching or weighting have become more common. Of late, even more flexible methods based on machine learning methods have been developed for statistical adjustment. These machine learning methods are designed to be black box methods with little input from th…
Causal effect estimation from observational data is a challenging problem, especially with high dimensional data and in the presence of unobserved variables. The available data-driven methods for tackling the problem either provide an estimation of the bounds of a causal effect (i.e. nonunique estimation) or have low efficiency. The major hurdle for achieving high efficiency while trying to obtain unique and unbiased causal effect estimation is how to find a proper adjustment set for confounding control in a fast way, given the huge covariate space and considering unobserved variables. In this…
Regression adjustments are often considered by investigators to improve the estimation efficiency of causal effect in randomized experiments when there exists many pre-experiment covariates. In this paper, we provide conditions that guarantee the penalized regression including the Ridge, Elastic Net and Adapive Lasso adjusted causal effect estimators are asymptotic normal and we show that their asymptotic variances are no greater than that of the simple difference-in-means estimator, as long as the penalized estimators are risk consistent. We also provide conservative estimators for the asympt…
Choosing the Right Approach at the Right Time: A Comparative Analysis of Causal Effect Estimation using Confounder Adjustment and Instrumental Variables
Confounding seriously impairs our ability to learn about causal relations from observational data. Confounding can be defined as a statistical association between two variables due to inputs from a common source (the confounder). For example, if $Z\rightarrow Y$ and $Z\rightarrow X$, then $X$ and $Y$ will be statistically dependent, even if there are no causal connections between the two. There are several approaches available to adjust for confounding, i.e. to remove, or reduce, the association between two variables due to the confounder. Common adjustment techniques include stratifying the a…
Unmeasured confounding is a threat to causal inference in observational studies. In recent years, use of negative controls to mitigate unmeasured confounding has gained increasing recognition and popularity. Negative controls have a longstanding tradition in laboratory sciences and epidemiology to rule out non-causal explanations, although they have been used primarily for bias detection. Recently, Miao et al. (2018) have described sufficient conditions under which a pair of negative control exposure and outcome variables can be used to nonparametrically identify the average treatment effect (…
University of South Australia（南澳大学）；Hefei University of Technology（合肥工业大学）
Causal effect estimation from observational data is a crucial but challenging task. Currently, only a limited number of data-driven causal effect estimation methods are available. These methods either provide only a bound estimation of the causal effect of a treatment on the outcome, or generate a unique estimation of the causal effect, but making strong assumptions on data and having low efficiency. In this paper, we identify a practical problem setting and propose an approach to achieving unique and unbiased estimation of causal effects from data with hidden variables. For the approach, we h…
Inference of Sample Complier Average Causal Effects under Experiments with Completely Randomized Design and Computer Assisted Balance-Improving Designs
The Clean Air Act mandates that the National Ambient Air Quality Standards (NAAQS) must be routinely assessed to protect populations based on the latest science. Therefore, researchers should continue to address whether exposure to levels of air pollution below the NAAQS is harmful to human health. The contentious nature surrounding environmental regulations urges us to cast this question within a causal inference framework. Parametric and semi-parametric regression approaches have been used to estimate the exposure-response (ER) curve between ambient air pollution and health outcomes. Most of…
University of Oxford（牛津大学）；The Alan Turing Institute（艾伦图灵研究所）；University College London（伦敦大学学院）
Discovering the causal effect of a decision is critical to nearly all forms of decision-making. In particular, it is a key quantity in drug development, in crafting government policy, and when implementing a real-world machine learning system. Given only observational data, confounders often obscure the true causal effect. Luckily, in some cases, it is possible to recover the causal effect by using certain observed variables to adjust for the effects of confounders. However, without access to the true causal model, finding this adjustment requires brute-force search. In this work, we present a…
The Regression Discontinuity (RD) design is a widely used non-experimental method for causal inference and program evaluation. While its canonical formulation only requires a score and an outcome variable, it is common in empirical work to encounter RD analyses where additional variables are used for adjustment. This practice has led to misconceptions about the role of covariate adjustment in RD analysis, from both methodological and empirical perspectives. In this chapter, we review the different roles of covariate adjustment in RD designs, and offer methodological guidance for its correct us…
The research questions that motivate transportation safety studies are causal in nature. Safety researchers typically use observational data to answer such questions, but often without appropriate causal inference methodology. The field of causal inference presents several modeling frameworks for probing empirical data to assess causal relations. This paper focuses on exploring the applicability of two such modeling frameworks---Causal Diagrams and Potential Outcomes---for a specific transportation safety problem. The causal effects of pavement marking retroreflectivity on safety of a road seg…
We consider the estimation of average and counterfactual treatment effects, under two settings: back-door adjustment and front-door adjustment. The goal in both cases is to recover the treatment effect without having an access to a hidden confounder. This objective is attained by first estimating the conditional mean of the desired outcome variable given relevant covariates (the "first stage" regression), and then taking the (conditional) expectation of this function as a "second stage" procedure. We propose to compute these conditional expectations directly using a regression function to the …
University of California, Berkeley（加州大学伯克利分校）；Columbia University（哥伦比亚大学）；University of Michigan（密歇根大学）
Causal inference from observational datasets often relies on measuring and adjusting for covariates. In practice, measurements of the covariates can often be noisy and/or biased, or only measurements of their proxies may be available. Directly adjusting for these imperfect measurements of the covariates can lead to biased causal estimates. Moreover, without additional assumptions, the causal effects are not point-identifiable due to the noise in these measurements. To this end, we study the partial identification of causal effects given noisy covariates, under a user-specified assumption on th…
University of Texas at Austin（德克萨斯大学奥斯汀分校）；Chalmers University of Technology（查尔姆斯理工大学）；Linköping University（林雪平大学）
Observational studies require adjustment for confounding factors that are correlated with both the treatment and outcome. In the setting where the observed variables are tabular quantities such as average income in a neighborhood, tools have been developed for addressing such confounding. However, in many parts of the developing world, features about local communities may be scarce. In this context, satellite imagery can play an important role, serving as a proxy for the confounding variables otherwise unobserved. In this paper, we study confounder adjustment in this non-tabular setting, where…
