基于DNA扭转的细胞命运相变模型
DNA Torsion-based Model of Cell Fate Phase Transitions
摘要：
所有的干细胞细胞命运转变，包括干细胞的代谢重编程和成纤维细胞向多能干细胞的体细胞重编程，都可以从细胞命运的统一理论模型来理解。每一个细胞命运转变都可以看作是DNA超螺旋中的一个相变。然而，一直缺乏定量的生物物理模型来解释和预测这些相变的行为。广义伊辛模型被提出来定义这样的相变。该模型预测，除了温度诱导的相变，存在DNA扭转频率诱导的相变。表观遗传状态的主要转变，从干细胞活化到分化和重编程，可以通过这种扭转频率诱导的相变来解释，这对未来的再生医学和医学诊断具有重要意义。
英文摘要：
All stem cell fate transitions, including the metabolic reprogramming of stem cells and the somatic reprogramming of fibroblasts into pluripotent stem cells, can be understood from a unified theoretical model of cell fates. Each cell fate transition can be regarded as a phase transition in DNA supercoiling. However, there has been a dearth of quantitative biophysical models to explain and predict the behaviors of these phase transitions. The generalized Ising model is proposed to define such phase transitions. The model predicts that, apart from temperature-induced phase transitions, there exists DNA torsion frequency-induced phase transitions. Major transitions in epigenetic states, from stem cell activation to differentiation and reprogramming, can be explained by such torsion frequency-induced phase transitions, with important implications for regenerative medicine and medical diagnostics in the future.
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