Outlier Guided Optimization of Abdominal Segmentation
Vanderbilt University（范德堡大学）；Sigma Technology（12西格玛技术公司）；Vanderbilt University Medical Center（范德堡大学医学中心）
Yuchen Xu, Olivia Tang, Yucheng Tang, Ho Hin Lee, Yunqiang Chen, Dashan Gao, Shizhong Han, Riqiang Gao, Michael R. Savona, Richard G. Abramson, Yuankai Huo, Bennett A. Landman
Abdominal multi-organ segmentation of computed tomography (CT) images has been the subject of extensive research interest. It presents a substantial challenge in medical image processing, as the shape and distribution of abdominal organs can vary greatly among the population and within an individual over time. While continuous integration of novel datasets into the training set provides potential for better segmentation performance, collection of data at scale is not only costly, but also impractical in some contexts. Moreover, it remains unclear what marginal value additional data have to offer. Herein, we propose a single-pass active learning method through human quality assurance (QA). We built on a pre-trained 3D U-Net model for abdominal multi-organ segmentation and augmented the dataset either with outlier data (e.g., exemplars for which the baseline algorithm failed) or inliers (e.g., exemplars for which the baseline algorithm worked). The new models were trained using the augmented datasets with 5-fold cross-validation (for outlier data) and withheld outlier samples (for inlier data). Manual labeling of outliers increased Dice scores with outliers by 0.130, compared to an increase of 0.067 with inliers (p<0.001, two-tailed paired t-test). By adding 5 to 37 inliers or outliers to training, we find that the marginal value of adding outliers is higher than that of adding inliers. In summary, improvement on single-organ performance was obtained without diminishing multi-organ performance or significantly increasing training time. Hence, identification and correction of baseline failure cases present an effective and efficient method of selecting training data to improve algorithm performance.
Imperial College London（帝国理工学院）；King’s College London（伦敦国王学院）；Friedrich–Alexander University Erlangen–Nürnberg（埃尔朗根-纽伦堡弗里德里希-亚历山大大学）
Supervised learning of every possible pathology is unrealistic for many primary care applications like health screening. Image anomaly detection methods that learn normal appearance from only healthy data have shown promising results recently. We propose an alternative to image reconstruction-based and image embedding-based methods and propose a new self-supervised method to tackle pathological anomaly detection. Our approach originates in the foreign patch interpolation (FPI) strategy that has shown superior performance on brain MRI and abdominal CT data. We propose to use a better patch inte…
ThreshGuide: Class-Aware Labeled-Guided Thresholding for Semi-Supervised 3D Abdominal Multi-Organ Segmentation
School of Intelligent Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences（中国科学院大学杭州高等研究院智能科学与技术学院）
University of Lübeck（吕贝克大学）；Imperial College London（帝国理工学院）；Brigham & Women’s Hospital（布莱根妇女医院）；Harvard Medical School（哈佛医学院）
Accurate and reliable segmentation of catheters in MR-guided interventions remains a challenge, and a step of critical importance in clinical workflows. In this work, under reasonable assumptions, mechanical model based heuristics guide the segmentation process allows correct catheter identification rates greater than 98% (error 2.88 mm), and reduction in outliers to one-fourth compared to the state of the art. Given distal tips, searching towards the proximal ends of the catheters is guided by mechanical models that are estimated on a per-catheter basis. Their bending characteristics are used…
Semi-supervised learning (semi-SL) is a promising alternative to supervised learning for medical image analysis when obtaining good quality supervision for medical imaging is difficult. However, semi-SL assumes that the underlying distribution of unaudited data matches that of the few labeled samples, which is often violated in practical settings, particularly in medical images. The presence of out-of-distribution (OOD) samples in the unlabeled training pool of semi-SL is inevitable and can reduce the efficiency of the algorithm. Common preprocessing methods to filter out outlier samples may n…
Imperial College London（伦敦帝国学院）；Aichi Cancer Center（爱知县癌症中心）；Nagoya University（名古屋大学）
To efficiently establish training databases for machine learning methods, collaborative and crowdsourcing platforms have been investigated to collectively tackle the annotation effort. However, when this concept is ported to the medical imaging domain, reading expertise will have a direct impact on the annotation accuracy. In this study, we examine the impact of expertise and the amount of available annotations on the accuracy outcome of a liver segmentation problem in an abdominal computed tomography (CT) image database. In controlled experiments, we study this impact for different types of w…
Active learning promises to improve annotation efficiency by iteratively selecting the most important data to be annotated first. However, we uncover a striking contradiction to this promise: active learning fails to select data as efficiently as random selection at the first few choices. We identify this as the cold start problem in vision active learning, caused by a biased and outlier initial query. This paper seeks to address the cold start problem by exploiting the three advantages of contrastive learning: (1) no annotation is required; (2) label diversity is ensured by pseudo-labels to m…
Univ Lyon（里昂大学）；INSA‐Lyon（里昂国立应用科学学院）；Université Claude Bernard Lyon 1（里昂第一大学）；UJM-Saint Etienne（圣艾蒂安让·莫奈大学）；CNRS（法国国家科学研究中心）；Inserm（法国国家健康与医学研究院）；CREATIS UMR 5220（CREATIS联合研究单位5220）；U1206（U1206研究单位）
Computer aided diagnosis (CAD) systems are designed to assist clinicians in various tasks, including highlighting abnormal regions in a medical image. A common approach consists in training a voxel-level binary classifier on a set of feature vectors extracted from normal and pathological areas in patients' scans. However, many pathologies (such as epilepsy) are characterized by lesions that may be located anywhere in the brain, have various shapes, sizes and texture. An adequate representation of such a heterogeneity requires a significant amount of annotated data which is a major issue in the…
Perelman School of Medicine at the University of Pennsylvania（宾夕法尼亚大学佩雷尔曼医学院）
Background: Out-of-plane lesions pose challenges for CT-guided interventions. Augmented reality (AR) headset devices have evolved and are readily capable to provide virtual 3D guidance to improve CT-guided targeting. Purpose: To describe the design of a three-dimensional (3D) AR-assisted navigation system using HoloLens 2 and evaluate its performance through CT-guided simulations. Materials and Methods: A prospective trial was performed assessing CT-guided needle targeting on an abdominal phantom with and without AR guidance. A total of 8 operators with varying clinical experience were enrolle…
The Chinese University of Hong Kong（香港中文大学）；Brigham and Women’s Hospital（布莱根妇女医院）；Harvard Medical School（哈佛医学院）；Tencent Jarvis Lab（腾讯医疗健康（深圳）有限公司（腾讯医疗AI实验室/腾讯天衍实验室））；Tsinghua University（清华大学）；Shenzhen International Graduate School, Tsinghua University（清华大学深圳国际研究生院）
In order to tackle the difficulty associated with the ill-posed nature of the image registration problem, regularization is often used to constrain the solution space. For most learning-based registration approaches, the regularization usually has a fixed weight and only constrains the spatial transformation. Such convention has two limitations: (i) Besides the laborious grid search for the optimal fixed weight, the regularization strength of a specific image pair should be associated with the content of the images, thus the "one value fits all" training scheme is not ideal; (ii) Only spatiall…
Shape reconstruction of deformable organs from two-dimensional X-ray images is a key technology for image-guided intervention. In this paper, we propose an image-to-graph convolutional network (IGCN) for deformable shape reconstruction from a single-viewpoint projection image. The IGCN learns relationship between shape/deformation variability and the deep image features based on a deformation mapping scheme. In experiments targeted to the respiratory motion of abdominal organs, we confirmed the proposed framework with a regularized loss function can reconstruct liver shapes from a single digit…
The Chinese University of Hong Kong（香港中文大学）；University of Leicester（莱斯特大学）
Domain adaptation is crucial for transferring the knowledge from the source labeled CT dataset to the target unlabeled MR dataset in abdominal multi-organ segmentation. Meanwhile, it is highly desirable to avoid the high annotation cost related to the target dataset and protect the source dataset privacy. Therefore, we propose an effective source-free unsupervised domain adaptation method for cross-modality abdominal multi-organ segmentation without source dataset access. The proposed framework comprises two stages. In the first stage, the feature map statistics-guided model adaptation combine…
Shenzhen University（深圳大学）；Shantou Central Hospital（汕头市中心医院）；The Affiliated Shantou Hospital of Sun Yat-sen University（中山大学附属汕头医院）
Efficient organ segmentation is the precondition of various quantitative analysis. Segmenting the pancreas from abdominal CT images is a challenging task because of its high anatomical variability in shape, size and location. What's more, the pancreas only occupies a small portion in abdomen, and the organ border is very fuzzy. All these factors make the segmentation methods of other organs less suitable for the pancreas segmentation. In this report, we propose a Markov Chain Monte Carlo (MCMC) sampling guided convolutional neural network (CNN) approach, in order to handle such difficulties in…
VMF-GOS: Geometry-guided virtual Outlier Synthesis for Long-Tailed OOD Detection
School of Computer and Electronic Information, Nanjing Normal University, China（南京师范大学计算机与电子信息学院）；School of Artificial Intelligence and Information Technology, Nanjing University of Chinese Medicine, China（南京中医药大学人工智能与信息技术学院）
Mask-guided Data Augmentation for Multiparametric MRI Generation with a Rare Hepatocellular Carcinoma
Universidad Industrial de Santander（桑坦德工业大学）；University of Toulouse（图卢兹大学）；Université Paul Sabatier Toulouse 3（图卢兹第三大学（保罗·萨巴蒂埃大学））；Bicêtre University Hospital（比塞特尔大学医院）；Assistance publique des hôpitaux de Paris（巴黎公共援助医院）；Université Claude Bernard Lyon 1（里昂第一大学（克洛德·贝尔纳里昂第一大学））
Encoding Structural Constraints into Segment Anything Models via Probabilistic Graphical Models
The George Washington University（乔治·华盛顿大学）；Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences（深圳先进技术研究所，中国科学院）；University of Alabama at Birmingham（阿拉巴马大学伯明翰分校）
Deep neural networks have significantly improved appearance-based gaze estimation accuracy. However, it still suffers from unsatisfactory performance when generalizing the trained model to new domains, e.g., unseen environments or persons. In this paper, we propose a plug-and-play gaze adaptation framework (PnP-GA), which is an ensemble of networks that learn collaboratively with the guidance of outliers. Since our proposed framework does not require ground-truth labels in the target domain, the existing gaze estimation networks can be directly plugged into PnP-GA and generalize the algorithms…
Vanderbilt University（范德堡大学）；Vanderbilt University Medical Center（范德堡大学医学中心）
Non-contrast computed tomography (NCCT) is commonly acquired for lung cancer screening, assessment of general abdominal pain or suspected renal stones, trauma evaluation, and many other indications. However, the absence of contrast limits distinguishing organ in-between boundaries. In this paper, we propose a novel unsupervised approach that leverages pairwise contrast-enhanced CT (CECT) context to compute non-contrast segmentation without ground-truth label. Unlike generative adversarial approaches, we compute the pairwise morphological context with CECT to provide teacher guidance instead of…
Objective : Abdominal anatomy segmentation is crucial for numerous applications from computer-assisted diagnosis to image-guided surgery. In this context, we address fully-automated multi-organ segmentation from abdominal CT and MR images using deep learning. Methods: The proposed model extends standard conditional generative adversarial networks. Additionally to the discriminator which enforces the model to create realistic organ delineations, it embeds cascaded partially pre-trained convolutional encoder-decoders as generator. Encoder fine-tuning from a large amount of non-medical images all…
Graduate School of Informatics, Kyoto University（京都大学信息学研究科）；Graduate School of Medicine, Kyoto University（京都大学医学研究科）
Organ shape reconstruction based on a single-projection image during treatment has wide clinical scope, e.g., in image-guided radiotherapy and surgical guidance. We propose an image-to-graph convolutional network that achieves deformable registration of a 3D organ mesh for a single-viewpoint 2D projection image. This framework enables simultaneous training of two types of transformation: from the 2D projection image to a displacement map, and from the sampled per-vertex feature to a 3D displacement that satisfies the geometrical constraint of the mesh structure. Assuming application to radiati…
Outlier-aware Tensor Robust Principal Component Analysis with Self-guided Data Augmentation
School of Mathematics and Statistics, Hunan Normal University（湖南师范大学数学与统计学学院）；School of Statistics and Mathematics, Yunnan University of Finance and Economics（云南财经大学统计与数学学院）
Revisiting Multimodal KV Cache Compression: A Frequency-Domain-Guided Outlier-KV-Aware Approach
College of Future Information Technology, Fudan University（未来信息科技学院，复旦大学）；Shanghai Innovation Institute（上海创新研究院）；The Chinese University of Hong Kong（香港中文大学）；Shanghai Artificial Intelligence Laboratory（上海人工智能实验室）；Zhangjiang Laboratory（张江实验室）
Seoul National University（首尔国立大学）；Soong-sil University（崇实大学）
Objective: Herein, a neural network-based liver segmentation algorithm is proposed, and its performance was evaluated using abdominal computed tomography (CT) images. Methods: A fully convolutional network was developed to overcome the volumetric image segmentation problem. To guide a neural network to accurately delineate a target liver object, the network was deeply supervised by applying the adaptive self-supervision scheme to derive the essential contour, which acted as a complement with the global shape. The discriminative contour, shape, and deep features were internally merged for the s…
A No-Reference Medical Image Quality Assessment Method Based on Automated Distortion Recognition Technology: Application to Preprocessing in MRI-guided Radiotherapy
Beijing University of Posts and Telecommunications（北京邮电大学）；National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College（中国医学科学院北京协和医学院国家癌症中心/国家癌症临床医学研究中心/肿瘤医院）
Indian Institute of Technology Roorkee（印度理工学院鲁尔基分校）；École de technologie Superieure（高等技术学院）
Even though convolutional neural networks (CNNs) are driving progress in medical image segmentation, standard models still have some drawbacks. First, the use of multi-scale approaches, i.e., encoder-decoder architectures, leads to a redundant use of information, where similar low-level features are extracted multiple times at multiple scales. Second, long-range feature dependencies are not efficiently modeled, resulting in non-optimal discriminative feature representations associated with each semantic class. In this paper we attempt to overcome these limitations with the proposed architectur…
DopQ-ViT: Towards Distribution-Friendly and Outlier-Aware Post-Training Quantization for Vision Transformers
Institute of Automation, Chinese Academy of Sciences（中国科学院自动化研究所）；School of Artificial Intelligence, University of Chinese Academy of Sciences（中国科学院大学人工智能学院）；Department of Computer Science, City University of Hong Kong（香港城市大学计算机科学系）
The Johns Hopkins University（约翰斯·霍普金斯大学）；The Johns Hopkins University School of Medicine（约翰斯·霍普金斯大学医学院）
We propose an intuitive approach of detecting pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, by checking abdominal CT scans. Our idea is named multi-scale segmentation-for-classification, which classifies volumes by checking if at least a sufficient number of voxels is segmented as tumors, by which we can provide radiologists with tumor locations. In order to deal with tumors with different scales, we train and test our volumetric segmentation networks with multi-scale inputs in a coarse-to-fine flowchart. A post-processing module is used to filter out outl…
Robust multiple model fitting plays a crucial role in many computer vision applications. Unlike single model fitting problems, the multi-model fitting has additional challenges. The unknown number of models and the inlier noise scale are the two most important of them, which are in general provided by the user using ground-truth or some other auxiliary information. Mode seeking/ clustering-based approaches crucially depend on the quality of model hypotheses generated. While preference analysis based guided sampling approaches have shown remarkable performance, they operate in a time budget fra…
The Chinese University of Hong Kong（香港中文大学）；The Chinese University of Hong Kong, Shenzhen（香港中文大学（深圳））
Recent works have shown that exploiting unlabeled data through label propagation can substantially reduce the labeling cost, which has been a critical issue in developing visual recognition models. Yet, how to propagate labels reliably, especially on a dataset with unknown outliers, remains an open question. Conventional methods such as linear diffusion lack the capability of handling complex graph structures and may perform poorly when the seeds are sparse. Latest methods based on graph neural networks would face difficulties on performance drop as they scale out to noisy graphs. To overcome …
Experts-Guided Unbalanced Optimal Transport for ISP Learning from Unpaired and/or Paired Data
Computer Vision Lab, CAIDAS & IFI, University of Würzburg（计算机视觉实验室，CAIDAS与IFI，乌尔姆大学）；Institute for Information Transmission Problems, RAS（信息传输问题研究所，俄罗斯科学院）；Moscow Institute of Physics and Technologies（莫斯科物理技术学院）；Artificial Intelligence Research Institute（人工智能研究 institute）
MoCrop: Training Free Motion Guided Cropping for Efficient Video Action Recognition
School of Computer Science, University College Dublin（计算机科学学院，都柏林大学学院）；Undergraduate School of Artificial Intelligence, Shenzhen Polytechnic University（人工智能本科学院，深圳职业技术大学）；School of Electrical and Electronic Engineering, University College Dublin（电子与电气工程学院，都柏林大学学院）
TRUSTED: The Paired 3D Transabdominal Ultrasound and CT Human Data for Kidney Segmentation and Registration Research
University of Strasbourg（斯特拉斯堡大学）；Research Institute against Digestive Cancer (IRCAD)（消化癌症研究所（IRCAD））；Conservatoire National des Arts et Métiers (CNAM)（法国国立工艺学院（CNAM））；Sorbonne University（索邦大学）；Clinique Sainte-Anne（圣安妮诊所）；Clinique Saint Augustin（圣奥古斯丁诊所）；Institute of Image-Guided Surgery (IHU)（图像引导手术研究所（IHU））
