Detection of Obstructive Sleep Apnoea Using Features Extracted from Segmented Time-Series ECG Signals Using a One Dimensional Convolutional Neural Network
Liverpool John Moores University（利物浦约翰摩尔斯大学）
Steven Thompson, Paul Fergus, Carl Chalmers, Denis Reilly
The study in this paper presents a one-dimensional convolutional neural network (1DCNN) model, designed for the automated detection of obstructive Sleep Apnoea (OSA) captured from single-channel electrocardiogram (ECG) signals. The system provides mechanisms in clinical practice that help diagnose patients suffering with OSA. Using the state-of-the-art in 1DCNNs, a model is constructed using convolutional, max pooling layers and a fully connected Multilayer Perceptron (MLP) consisting of a hidden layer and SoftMax output for classification. The 1DCNN extracts prominent features, which are used to train an MLP. The model is trained using segmented ECG signals grouped into 5 unique datasets of set window sizes. 35 ECG signal recordings were selected from an annotated database containing 70 night-time ECG recordings. (Group A = a01 to a20 (Apnoea breathing), Group B = b01 to b05 (moderate), and Group C = c01 to c10 (normal). A total of 6514 minutes of Apnoea was recorded. Evaluation of the model is performed using a set of standard metrics which show the proposed model achieves high classification results in both training and validation using our windowing strategy, particularly W=500 (Sensitivity 0.9705, Specificity 0.9725, F1 Score 0.9717, Kappa Score 0.9430, Log Loss 0.0836, ROCAUC 0.9945). This demonstrates the model can identify the presence of Apnoea with a high degree of accuracy.
Identifying sleep problem severity from overnight polysomnography (PSG) recordings plays an important role in diagnosing and treating sleep disorders such as the Obstructive Sleep Apnea (OSA). This analysis traditionally is done by specialists manually through visual inspections, which can be tedious, time-consuming, and is prone to subjective errors. One of the solutions is to use Convolutional Neural Networks (CNN) where the convolutional and pooling layers behave as feature extractors and some fully-connected (FCN) layers are used for making final predictions for the OSA severity. In this p…
Obstructive sleep apnea (OSA) is one of the most widespread respiratory diseases today. Complete or relative breathing cessations due to upper airway subsidence during sleep is OSA. It has confirmed potential influence on Covid-19 hospitalization and mortality, and is strongly associated with major comorbidities of severe Covid-19 infection. Un-diagnosed OSA may also lead to a variety of severe physical and mental side-effects. To score OSA severity, nocturnal sleep monitoring is performed under defined protocols and standards called polysomnography (PSG). This method is time-consuming, expens…
Deep Learning-based Automated Diagnosis of Obstructive Sleep Apnea and Sleep Stage Classification in Children Using Millimeter-wave Radar and Pulse Oximeter
Obstructive sleep apnea (OSA) is a common sleep disorder caused by abnormal breathing. The severity of OSA can lead to many symptoms such as sudden cardiac death (SCD). Polysomnography (PSG) is a gold standard for OSA diagnosis. It records many signals from the patient's body for at least one whole night and calculates the Apnea-Hypopnea Index (AHI) which is the number of apnea or hypopnea incidences per hour. This value is then used to classify patients into OSA severity levels. However, it has many disadvantages and limitations. Consequently, we proposed a novel methodology of OSA severity c…
The hidden Markov model (HMM) is a classic modeling tool with a wide swath of applications. Its inception considered observations restricted to a finite alphabet, but it was quickly extended to multivariate continuous distributions. In this article, we further extend the HMM from mixtures of normal distributions in $d$-dimensional Euclidean space to general Gaussian measure mixtures in locally convex topological spaces. The main innovation is the use of the Onsager-Machlup functional as a proxy for the probability density function in infinite dimensional spaces. This allows for choice of a Cam…
Obstructive Sleep Apnea (OSA) is a highly prevalent but inconspicuous disease that seriously jeopardizes the health of human beings. Polysomnography (PSG), the gold standard of detecting OSA, requires multiple specialized sensors for signal collection, hence patients have to physically visit hospitals and bear the costly treatment for a single detection. Recently, many single-sensor alternatives have been proposed to improve the cost efficiency and convenience. Among these methods, solutions based on RR-interval (i.e., the interval between two consecutive pulses) signals reach a satisfactory b…
Simultaneous Polysomnography and Cardiotocography Reveal Temporal Correlation Between Maternal Obstructive Sleep Apnea and Fetal Hypoxia
Shandong medical and pharmaceutical university hospital（山东医药大学医院）；National Institute of Health Data Science, Peking University（北京大学健康数据科学国家研究院）；Institute of Medical Technology, Peking University Health Science Center（北京大学医学部医疗技术研究所）；Saw Swee Hock School of Public Health, National University of Singapore（新加坡国立大学李光前公共卫生学院）；Department of Obstetrics and Gynecology, Peking University People’s Hospital（北京大学人民医院妇产科）；Division of Sleep Medicine, Peking University People’s Hospital（北京大学人民医院睡眠医学分部）
Faculty of Biomedical Engineering, Technion Institute of Technology（以色列理工学院 生物医学工程学院）；Faculty of Electrical Engineering, Technion Institute of Technology（以色列理工学院 电气工程学院）；Río Hortega University Hospital Valladolid（巴利亚多利德里奥奥尔塔加大学医院）；Biomedical Engineering Group, University of Valladolid（巴利亚多利德大学 生物医学工程组）；Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN)（生物工程、生物材料与纳米医学网络生物医学研究中心（CIBER-BBN））
Objective: Chronic obstructive pulmonary disease (COPD) is a highly prevalent chronic condition. COPD is a major source of morbidity, mortality and healthcare costs. Spirometry is the gold standard test for a definitive diagnosis and severity grading of COPD. However, a large proportion of individuals with COPD are undiagnosed and untreated. Given the high prevalence of COPD and its clinical importance, it is critical to develop new algorithms to identify undiagnosed COPD, especially in specific groups at risk, such as those with sleep disorder breathing. To our knowledge, no research has look…
Polysomnography (PSG) is the gold standard for diagnosing sleep obstructive apnea (OSA). It allows monitoring of breathing events throughout the night. The detection of these events is usually done by trained sleep experts. However, this task is tedious, highly time-consuming and subject to important inter-scorer variability. In this study, we adapted our state-of-the-art deep learning method for sleep event detection, DOSED, to the detection of sleep breathing events in PSG for the diagnosis of OSA. We used a dataset of 52 PSG recordings with apnea-hypopnea event scoring from 5 trained sleep …
Obstructive sleep Apnea (OSA) is a form of sleep disordered breathing characterized by frequent episodes of upper airway collapse during sleep. Pediatric OSA occurs in 1-5% of children and can related to other serious health conditions such as high blood pressure, behavioral issues, or altered growth. OSA is often diagnosed by studying the patient's sleep cycle, the pattern with which they progress through various sleep states such as wakefulness, rapid eye-movement, and non-rapid eye-movement. The sleep state data is obtained using an overnight polysomnography test that the patient undergoes …
The Breakthrough of Sleep: A Contactless Approach for Accurate Sleep Stage Detection Using the Sleepal AI Lamp
Hong Kong Xsmart Century Technology Co., Ltd.（香港Xsmart世纪科技有限公司）；Urban Mobility Lab, Massachusetts Institute of Technology（城市移动实验室，麻省理工学院）；Singapore-MIT Alliance for Research and Technology (SMART) Centre（新加坡-麻省理工联盟研究技术中心）；Department of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital（呼吸与危重症医学科，滨州医学院医院）；Interdisciplinary Center of Sleep Medicine, Charité – Universitätsmedizin Berlin（睡眠医学跨学科中心，夏里特-柏林大学医学中心）
The obstructive sleep apnea-hypopnea (OSAH) syndrome is a very common and frequently undiagnosed sleep disorder. It is characterized by repeated events of partial (hypopnea) or total (apnea) obstruction of the upper airway while sleeping. This study makes use of a previously developed method called DAS-KSVD for multiclass structured dictionary learning to automatically detect individual events of apnea and hypopnea using only blood oxygen saturation signals. The method uses a combined discriminant measure which is capable of efficiently quantifying the degree of discriminability of each one of…
Atrial fibrillation (AF) is the most prevalent arrhythmia and is associated with a five-fold increase in stroke risk. Many individuals with AF go undetected. These individuals are often asymptomatic. There are ongoing debates on whether mass screening for AF is to be recommended. However, there is incentive in performing screening for specific at risk groups such as individuals suspected of sleep-disordered breathing where an important association between AF and obstructive sleep apnea (OSA) has been demonstrated. We introduce a new methodology leveraging digital biomarkers and recent advances…
