利用Mo-92标记物的延迟γ能谱的新距离验证方法的GEANT4模拟
GEANT4 simulation of a new range verification method using delayed gamma spectroscopy of a Mo-92 marker
摘要：
在这项工作中，我们提出了一种新的技术在体内质子治疗范围验证。该技术利用小强子肿瘤标记物$^{92}$ Mo，在距临床治疗体积已知的短距离处植入。在治疗期间从标记物发射的信号可以提供在标记物的位置处的质子束能量的直接测量。质子束和标记核之间的聚变-蒸发反应导致延迟的特征$γ$射线的发射，其在束外被检测以提高信噪比。为了确定这种技术的可行性，并建立一个实验设置为未来的工作，蒙特卡罗包GEANT 4与根结合使用，以模拟治疗方案与本工作中概述的新方法。这些模拟表明，分析竞争反应产生的延迟$γ$射线的强度产生了质子束相对于标记物的范围的精确测量，具有亚毫米的不确定性。
英文摘要：
In this work, we propose a novel technique for in-vivo proton therapy range verification. This technique makes use of a small hadron tumour marker, $^{92}$Mo, implanted at a short known distance from the clinical treatment volume. Signals emitted from the marker during treatment can provide a direct measurement of the proton beam energy at the marker's position. Fusion-evaporation reactions between the proton beam and marker nucleus result in the emission of delayed characteristic $γ$ rays, which are detected off-beam for an improved signal-to-noise ratio. In order to determine the viability of this technique and to establish an experimental setup for future work, the Monte Carlo package GEANT4 was used in combination with ROOT to simulate a treatment scenario with the new method outlined in this work. These simulations show that analyzing the intensity of delayed $γ$ rays produced from competing reactions yields a precise measurement of the range of the proton beam relative to the marker, with sub-millimeter uncertainty.
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