氪离子辐照改性羟基磷灰石结构促进其溶解
Enhancement of hydroxyapatite dissolution through structure modification by Krypton ion irradiation
摘要：
用4MeV重氪离子对湿化学法合成的羟基磷灰石进行了不同注量的辐照。掠入射X射线衍射结果证实了辐照HA的相纯度与晶格参数的适度收缩，并进一步表明辐照引起的结构紊乱，证明了衍射峰的加宽。高分辨率透射电子显微镜观察表明，所施加的氪辐射引起的羟基磷灰石晶格中的显着损伤。具体而言，观察到的空腔与它们的直径和密度随辐照能量密度的变化，而辐射诱导的结晶到非晶的转变，随着离子剂量的增加被确定。拉曼和X射线光电子能谱学分析进一步表明存在辐照诱导的缺陷。从原始的和辐照的材料浸泡在Tris缓冲液中的离子释放表明，在体外的溶解增强照射。我们研究了辐射对小鼠成骨样细胞反应早期阶段的影响。进行细胞计数试剂盒8测定以研究样品的细胞毒性，并且可以在辐照材料上观察到活细胞。
英文摘要：
Hydroxyapatite synthesized by a wet chemical route was subjected to heavy Krypton ion irradiation of 4MeV at various fluences. Glancing incidence Xray diffraction results confirmed the phase purity of irradiated HA with a moderate contraction in lattice parameters, and further indicated the irradiation induced structural disorder, evidenced by broadening of the diffraction peaks. High resolution transmission electron microscopy observations indicated that the applied Kr irradiation induced significant damage in the hydroxyapatite lattice. Specifically, cavities were observed with their diameter and density varying with the irradiation fluences, while a radiation induced crystalline to amorphous transition with increasing ion dose was identified. Raman and Xray photoelectron spectroscopy analysis further indicated the presence of irradiation induced defects. Ion release from pristine and irradiated materials following immersion in Trisbuffer showed that dissolution in vitro was enhanced by irradiation. We examined the effects of irradiation on the early stages of the mouse osteoblast like cells response. A cell counting kit 8 assay was carried out to investigate the cytotoxicity of samples, and viable cells can be observed on the irradiated materials.
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