一步修饰电极用于汗液中维生素C的监测
Single-step modified electrodes for vitamin C monitoring in sweat
摘要：
我们展示了一个灵活的传感器，用于检测汗液中的抗坏血酸的基础上一步修饰的金微电极。该改性包括在电极顶部电沉积具有捕获的CuO纳米颗粒的藻酸盐膜。电极在薄的聚酰亚胺支撑物上制造，并且膜的柔软性质可以承受远远超出皮肤监测要求的机械应力。我们进一步显示了在超低施加电位（-5 mV）下，在中性缓冲液和酸性人工汗液两者中以微摩尔水平有效检测抗坏血酸。汗液中可能存在的干扰物质的影响被最小化，没有可观察到的交叉反应，因此尽管在制造方案中不存在酶，但仍保持高度的选择性。该传感器被设想为可穿戴设备的有前途的组件，用于例如通过汗液的微量营养素损失的非侵入性监测。
英文摘要：
We demonstrate a flexible sensor for ascorbic acid detection in sweat based on single-step modified gold microelectrodes. The modification consists on the electrodeposition of alginate membrane with trapped CuO nanoparticles on top of the electrodes. The electrodes are fabricated at a thin polyimide support and the soft nature of the membrane can withstand mechanical stress far beyond the requirements for skin monitoring. We further show the efficient detection of ascorbic acid at the micromolar levels in both, a neutral buffer and acidic artificial sweat, at ultra-low applied potential (-5 mV). The effect of possible interfering species present in sweat is minimized, with no observable cross-reaction, thus maintaining a high degree of selectivity despite absence of enzymes in the fabrication scheme. This sensor is envisioned as a promising component of a wearable device for e.g. non-invasive monitoring of micronutrient loss through sweat.
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