The Ideal Observer (IO) performance has been advocated when optimizing medical imaging systems for signal detection tasks. However, analytical computation of the IO test statistic is generally intractable. To approximate the IO test statistic, sampling-based methods that employ Markov-Chain Monte Carlo (MCMC) techniques have been developed. However, current applications of MCMC techniques have been limited to several object models such as a lumpy object model and a binary texture model, and it remains unclear how MCMC methods can be implemented with other more sophisticated object models. Deep learning methods that employ generative adversarial networks (GANs) hold great promise to learn stochastic object models (SOMs) from image data. In this study, we described a method to approximate the IO by applying MCMC techniques to SOMs learned by use of GANs. The proposed method can be employed with arbitrary object models that can be learned by use of GANs, thereby the domain of applicability of MCMC techniques for approximating the IO performance is extended. In this study, both signal-known-exactly (SKE) and signal-known-statistically (SKS) binary signal detection tasks are considered. The IO performance computed by the proposed method is compared to that computed by the conventional MCMC method. The advantages of the proposed method are discussed.
Ideal Observer Computation by Use of Markov-Chain Monte Carlo with Generative Adversarial Networks
Global Institute of Future Technology, Shanghai Jiao Tong University（上海交通大学未来技术全球研究院）；Oden Institute for Computational Engineering & Sciences, The University of Texas at Austin（德克萨斯大学奥斯汀分校奥登计算工程与科学研究所）；Department of Bioengineering, University of Illinois Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校生物工程系）
Institut for Informatik, University of Mainz（美因茨大学信息学研究所）
This paper proposes Markovian Generative Adversarial Networks (MGANs), a method for training generative neural networks for efficient texture synthesis. While deep neural network approaches have recently demonstrated remarkable results in terms of synthesis quality, they still come at considerable computational costs (minutes of run-time for low-res images). Our paper addresses this efficiency issue. Instead of a numerical deconvolution in previous work, we precompute a feed-forward, strided convolutional network that captures the feature statistics of Markovian patches and is able to directly…
Washington University in St. Louis（圣路易斯华盛顿大学）；University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）；Carle Foundation Hospital（卡尔基金会医院）
It is widely accepted that optimization of medical imaging system performance should be guided by task-based measures of image quality (IQ). Task-based measures of IQ quantify the ability of an observer to perform a specific task such as detection or estimation of a signal (e.g., a tumor). For binary signal detection tasks, the Bayesian Ideal Observer (IO) sets an upper limit of observer performance and has been advocated for use in optimizing medical imaging systems and data-acquisition designs. Except in special cases, determination of the IO test statistic is analytically intractable. Marko…
Existing Markov Chain Monte Carlo (MCMC) methods are either based on general-purpose and domain-agnostic schemes which can lead to slow convergence, or hand-crafting of problem-specific proposals by an expert. We propose A-NICE-MC, a novel method to train flexible parametric Markov chain kernels to produce samples with desired properties. First, we propose an efficient likelihood-free adversarial training method to train a Markov chain and mimic a given data distribution. Then, we leverage flexible volume preserving flows to obtain parametric kernels for MCMC. Using a bootstrap approach, we sh…
University of Edinburgh（爱丁堡大学）；SeeByte Ltd.（SeeByte有限公司）
Deployment and operation of autonomous underwater vehicles is expensive and time-consuming. High-quality realistic sonar data simulation could be of benefit to multiple applications, including training of human operators for post-mission analysis, as well as tuning and validation of autonomous target recognition (ATR) systems for underwater vehicles. Producing realistic synthetic sonar imagery is a challenging problem as the model has to account for specific artefacts of real acoustic sensors, vehicle altitude, and a variety of environmental factors. We propose a novel method for generating re…
Washington University in St. Louis（圣路易斯华盛顿大学）；University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）
Medical imaging systems are commonly assessed and optimized by use of objective measures of image quality (IQ). The Ideal Observer (IO) performance has been advocated to provide a figure-of-merit for use in assessing and optimizing imaging systems because the IO sets an upper performance limit among all observers. When joint signal detection and localization tasks are considered, the IO that employs a modified generalized likelihood ratio test maximizes observer performance as characterized by the localization receiver operating characteristic (LROC) curve. Computations of likelihood ratios ar…
Centre for Intelligent Machines, McGill University（麦吉尔大学智能机器中心）
Most existing saliency models use low-level features or task descriptions when generating attention predictions. However, the link between observer characteristics and gaze patterns is rarely investigated. We present a novel saliency prediction technique which takes viewers' identities and personal traits into consideration when modeling human attention. Instead of only computing image salience for average observers, we consider the interpersonal variation in the viewing behaviors of observers with different personal traits and backgrounds. We present an enriched derivative of the GAN network,…
Technion - Israel Institute of Technology（以色列理工学院）
Contrastive divergence (CD) learning is a classical method for fitting unnormalized statistical models to data samples. Despite its wide-spread use, the convergence properties of this algorithm are still not well understood. The main source of difficulty is an unjustified approximation which has been used to derive the gradient of the loss. In this paper, we present an alternative derivation of CD that does not require any approximation and sheds new light on the objective that is actually being optimized by the algorithm. Specifically, we show that CD is an adversarial learning procedure, whe…
A major obstacle in radar based methods for concealed object detection on humans and seamless integration into security and access control system is the difficulty in collecting high quality radar signal data. Generative adversarial networks (GAN) have shown promise in data generation application in the fields of image and audio processing. As such, this paper proposes the design of a GAN for application in radar signal generation. Data collected using the Finite-Difference Time-Domain (FDTD) method on three concealed object classes (no object, large object, and small object) were used as trai…
Adversarial examples are intentionally crafted data with the purpose of deceiving neural networks into misclassification. When we talk about strategies to create such examples, we usually refer to perturbation-based methods that fabricate adversarial examples by applying invisible perturbations onto normal data. The resulting data reserve their visual appearance to human observers, yet can be totally unrecognizable to DNN models, which in turn leads to completely misleading predictions. In this paper, however, we consider crafting adversarial examples from existing data as a limitation to exam…
Korea Advanced Institute of Science and Technology（韩国科学技术院）；AITRICS
While adversarial training is considered as a standard defense method against adversarial attacks for image classifiers, adversarial purification, which purifies attacked images into clean images with a standalone purification model, has shown promises as an alternative defense method. Recently, an Energy-Based Model (EBM) trained with Markov-Chain Monte-Carlo (MCMC) has been highlighted as a purification model, where an attacked image is purified by running a long Markov-chain using the gradients of the EBM. Yet, the practicality of the adversarial purification using an EBM remains questionab…
Recently, sampling methods have been successfully applied to enhance the sample quality of Generative Adversarial Networks (GANs). However, in practice, they typically have poor sample efficiency because of the independent proposal sampling from the generator. In this work, we propose REP-GAN, a novel sampling method that allows general dependent proposals by REParameterizing the Markov chains into the latent space of the generator. Theoretically, we show that our reparameterized proposal admits a closed-form Metropolis-Hastings acceptance ratio. Empirically, extensive experiments on synthetic…
University of Massachusetts Amherst（马萨诸塞大学阿默斯特分校）；US Army Research Laboratory（美国陆军研究实验室）
In this paper, we consider the problem of assessing the adversarial robustness of deep neural network models under both Markov chain Monte Carlo (MCMC) and Bayesian Dark Knowledge (BDK) inference approximations. We characterize the robustness of each method to two types of adversarial attacks: the fast gradient sign method (FGSM) and projected gradient descent (PGD). We show that full MCMC-based inference has excellent robustness, significantly outperforming standard point estimation-based learning. On the other hand, BDK provides marginal improvements. As an additional contribution, we presen…
We introduce the Metropolis-Hastings generative adversarial network (MH-GAN), which combines aspects of Markov chain Monte Carlo and GANs. The MH-GAN draws samples from the distribution implicitly defined by a GAN's discriminator-generator pair, as opposed to standard GANs which draw samples from the distribution defined only by the generator. It uses the discriminator from GAN training to build a wrapper around the generator for improved sampling. With a perfect discriminator, this wrapped generator samples from the true distribution on the data exactly even when the generator is imperfect. W…
Universitat Pompeu Fabra（庞培法布拉大学）；Universitat de València（瓦伦西亚大学）
Visual illusions are a very useful tool for vision scientists, because they allow them to better probe the limits, thresholds and errors of the visual system. In this work we introduce the first ever framework to generate novel visual illusions with an artificial neural network (ANN). It takes the form of a generative adversarial network, with a generator of visual illusion candidates and two discriminator modules, one for the inducer background and another that decides whether or not the candidate is indeed an illusion. The generality of the model is exemplified by synthesizing illusions of d…
TECNALIA（特克纳利亚研究与创新中心）；CVC - Universitat Autònoma de Barcelona（巴塞罗那自治大学计算机视觉中心）
Hyperspectral signal reconstruction aims at recovering the original spectral input that produced a certain trichromatic (RGB) response from a capturing device or observer. Given the heavily underconstrained, non-linear nature of the problem, traditional techniques leverage different statistical properties of the spectral signal in order to build informative priors from real world object reflectances for constructing such RGB to spectral signal mapping. However, most of them treat each sample independently, and thus do not benefit from the contextual information that the spatial dimensions can …
Signal and Image Processing Institute, University of Southern California（南加州大学信号与图像处理研究所）
The problem of learning from positive and unlabeled data (A.K.A. PU learning) has been studied in a binary (i.e., positive versus negative) classification setting, where the input data consist of (1) observations from the positive class and their corresponding labels, (2) unlabeled observations from both positive and negative classes. Generative Adversarial Networks (GANs) have been used to reduce the problem to the supervised setting with the advantage that supervised learning has state-of-the-art accuracy in classification tasks. In order to generate \textit{pseudo}-negative observations, GA…
Dublin City University（都柏林城市大学）；Universitat Politecnica de Catalunya（加泰罗尼亚理工大学）
We introduce PathGAN, a deep neural network for visual scanpath prediction trained on adversarial examples. A visual scanpath is defined as the sequence of fixation points over an image defined by a human observer with its gaze. PathGAN is composed of two parts, the generator and the discriminator. Both parts extract features from images using off-the-shelf networks, and train recurrent layers to generate or discriminate scanpaths accordingly. In scanpath prediction, the stochastic nature of the data makes it very difficult to generate realistic predictions using supervised learning strategies…
One of the biggest issues facing the use of machine learning in medical imaging is the lack of availability of large, labelled datasets. The annotation of medical images is not only expensive and time consuming but also highly dependent on the availability of expert observers. The limited amount of training data can inhibit the performance of supervised machine learning algorithms which often need very large quantities of data on which to train to avoid overfitting. So far, much effort has been directed at extracting as much information as possible from what data is available. Generative Adver…
University of Texas MD Anderson Cancer Center（德克萨斯大学MD安德森癌症中心）；Indiana University School of Medicine（印第安纳大学医学院）
In clinical diagnostics and research involving histopathology, formalin fixed paraffin embedded (FFPE) tissue is almost universally favored for its superb image quality. However, tissue processing time (more than 24 hours) can slow decision-making. In contrast, fresh frozen (FF) processing (less than 1 hour) can yield rapid information but diagnostic accuracy is suboptimal due to lack of clearing, morphologic deformation and more frequent artifacts. Here, we bridge this gap using artificial intelligence. We synthesize FFPE-like images ,virtual FFPE, from FF images using a generative adversaria…
Universitat de Barcelona（巴塞罗那大学）；Erasmus MC（伊拉斯姆斯医学中心）；Imperial College London（帝国理工学院）
Despite technological and medical advances, the detection, interpretation, and treatment of cancer based on imaging data continue to pose significant challenges. These include inter-observer variability, class imbalance, dataset shifts, inter- and intra-tumour heterogeneity, malignancy determination, and treatment effect uncertainty. Given the recent advancements in Generative Adversarial Networks (GANs), data synthesis, and adversarial training, we assess the potential of these technologies to address a number of key challenges of cancer imaging. We categorise these challenges into (a) data s…
Deepfake represents a category of face-swapping attacks that leverage machine learning models such as autoencoders or generative adversarial networks. Although the concept of the face-swapping is not new, its recent technical advances make fake content (e.g., images, videos) more realistic and imperceptible to Humans. Various detection techniques for Deepfake attacks have been explored. These methods, however, are passive measures against Deepfakes as they are mitigation strategies after the high-quality fake content is generated. More importantly, we would like to think ahead of the attackers…
Vrije Universiteit Amsterdam（阿姆斯特丹自由大学）；Universiteit van Amsterdam（阿姆斯特丹大学）
Variational autoencoders (VAEs) are latent variable models that can generate complex objects and provide meaningful latent representations. Moreover, they could be further used in downstream tasks such as classification. As previous work has shown, one can easily fool VAEs to produce unexpected latent representations and reconstructions for a visually slightly modified input. Here, we examine several objective functions for adversarial attack construction proposed previously and present a solution to alleviate the effect of these attacks. Our method utilizes the Markov Chain Monte Carlo (MCMC)…
The ideal observer (IO) sets an upper performance limit among all observers and has been advocated for assessing and optimizing imaging systems. For general joint detection and estimation (detection-estimation) tasks, estimation ROC (EROC) analysis has been established for evaluating the performance of observers. However, in general, it is difficult to accurately approximate the IO that maximizes the area under the EROC curve. In this study, a hybrid method that employs machine learning is proposed to accomplish this. Specifically, a hybrid approach is developed that combines a multi-task conv…
