二核小体的解包裹
Insight into the Unwrapping of the Dinucleosome
摘要：
核小体作为染色质的基本组成部分，其动态变化对真核生物基因组的表达、复制和修复有着重要的影响。除了核小体通过热波动的恒定运动之外，ATP依赖的染色质重塑复合物引起它们的主动位移。在这里，我们提出了一个理论分析的双核体包装和解包动力学在外力的存在下。我们探讨了双核小体在不同解包态下的能量分布和构型。此外，使用动态Monte-Carlo模拟算法，我们展示了系统的动力学特性，如部分和完全包裹过程的解包裹力。此外，我们发现，在短长度的接头DNA（$\sim 10 - 90$ bp），不对称解缠绕发生。这些发现可以为染色质动力学和基因可及性提供一些线索。
英文摘要：
Dynamics of nucleosomes, the building blocks of the chromatin, has crucial effects on expression, replication and repair of genomes in eukaryotes. Beside constant movements of nucleosomes by thermal fluctuations, ATP-dependent chromatin remodelling complexes cause their active displacements. Here we propose a theoretical analysis of dinucleosome wrapping and unwrapping dynamics in the presence of an external force. We explore the energy landscape and configurations of dinucleosome in different unwrapped states. Moreover, using a dynamical Monte-Carlo simulation algorithm, we demonstrate the dynamical features of the system such as the unwrapping force for partial and full wrapping processes. Furthermore, we show that in the short length of linker DNA ($\sim 10 - 90$ bp), the asymmetric unwrapping occurs. These findings could shed some light on chromatin dynamics and gene accessibility.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
