Secure and Robust Machine Learning for Healthcare: A Survey
University of the West England (UWE)（西英格兰大学（UWE））；Hamad Bin Khalifa University (HBKU)（哈马德·本·哈利法大学（HBKU））；Information Technology University (ITU)（信息技术大学（ITU））
Adnan Qayyum, Junaid Qadir, Muhammad Bilal, Ala Al-Fuqaha
Recent years have witnessed widespread adoption of machine learning (ML)/deep learning (DL) techniques due to their superior performance for a variety of healthcare applications ranging from the prediction of cardiac arrest from one-dimensional heart signals to computer-aided diagnosis (CADx) using multi-dimensional medical images. Notwithstanding the impressive performance of ML/DL, there are still lingering doubts regarding the robustness of ML/DL in healthcare settings (which is traditionally considered quite challenging due to the myriad security and privacy issues involved), especially in light of recent results that have shown that ML/DL are vulnerable to adversarial attacks. In this paper, we present an overview of various application areas in healthcare that leverage such techniques from security and privacy point of view and present associated challenges. In addition, we present potential methods to ensure secure and privacy-preserving ML for healthcare applications. Finally, we provide insight into the current research challenges and promising directions for future research.
Parkland Center for Clinical Innovation（帕克兰临床创新中心）；Dallas, TX 75247, USA（美国得克萨斯州达拉斯市75247（注：此条为地址，非机构，按要求不应提取，实际仅需保留Parkland Center for Clinical Innovation））
In recent times, machine learning (ML) and artificial intelligence (AI) based systems have evolved and scaled across different industries such as finance, retail, insurance, energy utilities, etc. Among other things, they have been used to predict patterns of customer behavior, to generate pricing models, and to predict the return on investments. But the successes in deploying machine learning models at scale in those industries have not translated into the healthcare setting. There are multiple reasons why integrating ML models into healthcare has not been widely successful, but from a techni…
National College of Business Administration and Economics（国家工商经济学院）；Riphah International University（里法哈国际大学）；Skyline University College（天际线大学学院）；Universiti Kebangsaan Malaysia（马来西亚国民大学）；Gachon University（加川大学）；Slovak University of Technology in Bratislava（布拉迪斯拉发斯洛伐克理工大学）；Obuda University（欧布达大学）；TU-Dresden（德累斯顿工业大学）
In recent years, the global Internet of Medical Things (IoMT) industry has evolved at a tremendous speed. Security and privacy are key concerns on the IoMT, owing to the huge scale and deployment of IoMT networks. Machine learning (ML) and blockchain (BC) technologies have significantly enhanced the capabilities and facilities of healthcare 5.0, spawning a new area known as "Smart Healthcare." By identifying concerns early, a smart healthcare system can help avoid long-term damage. This will enhance the quality of life for patients while reducing their stress and healthcare costs. The IoMT ena…
Hybrid RAG-empowered Multi-modal LLM for Secure Data Management in Internet of Medical Things: A Diffusion-based Contract Approach
Guangdong University of Technology（广东工业大学）；Nanjing University of Aeronautics and Astronautics（南京航空航天大学）；Guangzhou University of Traditional Chinese Medicine（广州中医药大学）；The Second Affiliated Hospital of Guangzhou University of Chinese Medicine（广州中医药大学第二附属医院）
University of Tuebingen（蒂宾根大学）；University Hospital Tuebingen（蒂宾根大学医院）；Max Planck Institute for Informatics（马克斯·普朗克信息学研究所）
To train sophisticated machine learning models one usually needs many training samples. Especially in healthcare settings these samples can be very expensive, meaning that one institution alone usually does not have enough on its own. Merging privacy-sensitive data from different sources is usually restricted by data security and data protection measures. This can lead to approaches that reduce data quality by putting noise onto the variables (e.g., in $ε$-differential privacy) or omitting certain values (e.g., for $k$-anonymity). Other measures based on cryptographic methods can lead to very …
Deakin University（迪肯大学）；Pusan National University（釜山国立大学）；CSIRO（澳大利亚联邦科学与工业研究组织）；University of New South Wales（新南威尔士大学）；The University of Sydney（悉尼大学）；Memorial University（纪念大学）
Recent advances in communication technologies and Internet-of-Medical-Things have transformed smart healthcare enabled by artificial intelligence (AI). Traditionally, AI techniques require centralized data collection and processing that may be infeasible in realistic healthcare scenarios due to the high scalability of modern healthcare networks and growing data privacy concerns. Federated Learning (FL), as an emerging distributed collaborative AI paradigm, is particularly attractive for smart healthcare, by coordinating multiple clients (e.g., hospitals) to perform AI training without sharing …
Recognizing the patient's emotions using deep learning techniques has attracted significant attention recently due to technological advancements. Automatically identifying the emotions can help build smart healthcare centers that can detect depression and stress among the patients in order to start the medication early. Using advanced technology to identify emotions is one of the most exciting topics as it defines the relationships between humans and machines. Machines learned how to predict emotions by adopting various methods. In this survey, we present recent research in the field of using …
Sun Yat-sen University（中山大学）；Hong Kong Baptist University（香港浸会大学）；UC San Diego（加州大学圣地亚哥分校）
As a subfield of machine learning, reinforcement learning (RL) aims at empowering one's capabilities in behavioural decision making by using interaction experience with the world and an evaluative feedback. Unlike traditional supervised learning methods that usually rely on one-shot, exhaustive and supervised reward signals, RL tackles with sequential decision making problems with sampled, evaluative and delayed feedback simultaneously. Such distinctive features make RL technique a suitable candidate for developing powerful solutions in a variety of healthcare domains, where diagnosing decisio…
ConsenSys Health；Imperial College London（帝国理工学院）；UC San Diego（加州大学圣地亚哥分校）；Johns Hopkins Berman Institute of Bioethics（约翰斯·霍普金斯大学伯曼生物伦理研究所）
We propose a novel architecture for federated learning within healthcare consortia. At the heart of the solution is a unique integration of privacy preserving technologies, built upon native enterprise blockchain components available in the Ethereum ecosystem. We show how the specific characteristics and challenges of healthcare consortia informed our design choices, notably the conception of a new Secure Aggregation protocol assembled with a protected hardware component and an encryption toolkit native to Ethereum. Our architecture also brings in a privacy preserving audit trail that logs eve…
University of Quebec（魁北克大学）；ETS（高等技术学院）；Princeton University（普林斯顿大学）
Recent advances in electronic devices and communication infrastructure have revolutionized the traditional healthcare system into a smart healthcare system by using IoMT devices. However, due to the centralized training approach of artificial intelligence (AI), the use of mobile and wearable IoMT devices raises privacy concerns with respect to the information that has been communicated between hospitals and end users. The information conveyed by the IoMT devices is highly confidential and can be exposed to adversaries. In this regard, federated learning (FL), a distributive AI paradigm has ope…
Differentially private federated learning with Byzantine-robust aggregation: A cross-domain framework for secure model training in banking and healthcare systems
Generative AI-Driven Human Digital Twin in IoT-Healthcare: A Comprehensive Survey
College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics（南京航空航天大学计算机科学与技术学院）；School of Computer Science and Engineering, Nanyang Technological University（南洋理工大学计算机科学与工程学院）；School of Automation, Guangdong University of Technology（广东工业大学自动化学院）
The increasing availability of large collections of electronic health record (EHR) data and unprecedented technical advances in deep learning (DL) have sparked a surge of research interest in developing DL based clinical decision support systems for diagnosis, prognosis, and treatment. Despite the recognition of the value of deep learning in healthcare, impediments to further adoption in real healthcare settings remain due to the black-box nature of DL. Therefore, there is an emerging need for interpretable DL, which allows end users to evaluate the model decision making to know whether to acc…
College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation（卡塔尔基金会哈马德·本·哈利法大学科学与工程学院）；College of Engineering, Qatar University（卡塔尔大学工程学院）
The rapid increase in the percentage of chronic disease patients along with the recent pandemic pose immediate threats on healthcare expenditure and elevate causes of death. This calls for transforming healthcare systems away from one-on-one patient treatment into intelligent health systems, to improve services, access and scalability, while reducing costs. Reinforcement Learning (RL) has witnessed an intrinsic breakthrough in solving a variety of complex problems for diverse applications and services. Thus, we conduct in this paper a comprehensive survey of the recent models and techniques of…
Over the years, several studies have demonstrated that there exist significant disparities in health indicators in the United States population across various groups. Healthcare expense is used as a proxy for health in algorithms that drive healthcare systems and this exacerbates the existing bias. In this work, we focus on the presence of racial bias in health indicators in the publicly available, and nationally representative Medical Expenditure Panel Survey (MEPS) data. We show that predictive models for care management trained using this data inherit this bias. Finally, we demonstrate that…
Federated learning is the process of developing machine learning models over datasets distributed across data centers such as hospitals, clinical research labs, and mobile devices while preventing data leakage. This survey examines previous research and studies on federated learning in the healthcare sector across a range of use cases and applications. Our survey shows what challenges, methods, and applications a practitioner should be aware of in the topic of federated learning. This paper aims to lay out existing research and list the possibilities of federated learning for healthcare indust…
Ontology- and LLM-based Data Harmonization for Federated Learning in Healthcare
Institute of Informatics University of Amsterdam（信息学院阿姆斯特丹大学）；College of Medicine The Ohio State University（医学学院俄亥俄州立大学）；Department of Neuroscience University of California（神经科学系加州大学）；School of Medicine Indiana University（医学院印第安纳大学）
A survey on secure decentralized optimization and learning
KTH Royal Institute of Technology（KTH皇家理工学院）；Digital Futures（数字未来机构）；Hong Kong University of Science and Technology（香港科技大学）；University of Victoria（维多利亚大学）
Georgia State University（佐治亚州立大学）；Shenzhen Institute of Advanced Technology, CAS（中国科学院深圳先进技术研究院）
Generative Adversarial Networks (GAN) have promoted a variety of applications in computer vision, natural language processing, etc. due to its generative model's compelling ability to generate realistic examples plausibly drawn from an existing distribution of samples. GAN not only provides impressive performance on data generation-based tasks but also stimulates fertilization for privacy and security oriented research because of its game theoretic optimization strategy. Unfortunately, there are no comprehensive surveys on GAN in privacy and security, which motivates this survey paper to summa…
A Comprehensive Survey of Foundation Models in Medicine
Herbert Wertheim College of Engineering, University of Florida（佛罗里达大学赫伯特·沃特海姆工程学院）；Norman Fixel Institute for Neurological Diseases, University of Florida（佛罗里达大学诺曼·菲克塞尔神经疾病研究所）；University of North Carolina at Charlotte（北卡罗来纳大学夏洛特分校）；McKnight Brain Institute, University of Florida（佛罗里达大学麦克奈特脑科学研究所）
Blockchain-empowered Federated Learning for Healthcare Metaverses: User-centric Incentive Mechanism with Optimal Data Freshness
Guangdong University of Technology（广东工业大学）；Singapore University of Technology and Design（新加坡科技设计大学）；Nanyang Technological University（南洋理工大学）；Nanjing University of Aeronautics and Astronautics（南京航空航天大学）
