缺血性卒中侧支循环评分的研究
Towards a Computed Collateral Circulation Score in Ischemic Stroke
摘要：
中风是全球第二大致残原因。为了尽量减少残疾，中风治疗的目标是保存血液供应减少但足以避免细胞死亡的区域的组织。血栓切除术已被证明可提供快速有效的再灌注，再通率高。然而，由于血栓切除术的固有风险，应存在包括良好侧支循环证据在内的适应症。目前，用于评估侧支循环的方法是有限的。在这项工作中，我们提出了一种自动化的技术来计算侧支循环评分的基础上看到的差异，在4D血管造影图像的左，右大脑半球之间的平均强度。在这项初步研究中，我们分析了28例受试者的扫描结果：4例侧支循环正常，7例良好，10例中等，7例不良侧支循环（基于放射科医师评分），发现计算评分和放射科医师评分之间具有良好的相关性（r2 = 0.71），良好组和中等/不良组之间具有良好的分离。这项工作表明，作为建立自动化抵押循环评分的第一步，有希望。
英文摘要：
Stroke is the second leading cause of disability worldwide. In order to minimize disability, the goal of stroke treatment is to preserve tissue in the area where blood supply is decreased but sufficient to stave off cell death. Thrombectomy has been shown to offer fast and efficient reperfusion with high recanalization rates. However, due to the inherent risks of thrombectomy, indications including evidence of good collateral circulation should be present. Currently, methods for evaluating collateral circulation are limited. In this work, we present an automated technique to compute a collateral circulation score based on differences seen in mean intensities between left and right cerebral hemispheres in 4D angiography images. In this preliminary study, we analyzed scans of 28 subjects: 4 with normal collateral circulation, 7 with good, 10 with intermediate, and 7 with poor collateral circulation, (based on radiologist score) and found a good correlation between the computed score and radiologist score (r2 = 0.71) and good separation between good and intermediate/poor groups. This work shows promise as the first step in building an automated collateral circulation score.
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