细胞骨架极性是决定多纤毛细胞基体取向顺序的关键
Cytoskeleton polarity is essential in determining orientational order in basal bodies of multi-ciliated cells
摘要：
气管中纤毛的同步和定向跳动允许病毒和灰尘从体内运输和排出。这种纤毛功能依赖于顶端细胞膜中的基底体（纤毛根）的协调构型。然而，其形成机制仍然未知。在这项研究中，我们表明，在顶端微管束的极性起着重要的作用，在组织的基体。结合极性的数学模型已经制定了一个连贯的解释，并能够重现实验观察。我们阐明了细胞骨架极性的必要性（“为什么极性是图案形成所必需的”）和充分性（“极性如何对图案形成起作用”），并通过实验数据进行了验证。这个模型进一步引导我们到一个可能的机制，细胞手性。
英文摘要：
Synchronous and directed ciliary beating in trachea allows transport and ejection of virus and dust from the body. This ciliary function depends on the coordinated configuration of basal bodies (root of cilia) in apical cell membrane. However, the mechanism for their formation remains unknown. In this study, we show that the polarity in apical microtubule bundles plays a significant role in the organization of basal bodies. A mathematical model incorporating polarity has been formulated which provides a coherent explanation and is able to reproduce experimental observations. We have clarified both necessity ('why polarity is required for pattern formation') and sufficiency ('how polarity works for pattern formation') of cytoskeleton polarity for correct pattering of basal bodies with verification by experimental data. This model further leads us to a possible mechanism for cellular chirality.
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