解释系留粒子运动实验的统计物理和介观模型
Statistical physics and mesoscopic modeling to interpret tethered particle motion experiments
摘要：
拴系粒子运动实验是一种多功能的单分子技术，使人们能够在体外处理DNA的分子特性及其与参与遗传调控的各种伙伴的相互作用。这些技术提供了原始数据，如跟踪粒子的运动幅度，从中必须恢复有关DNA构象或状态的相关信息。解决这个逆问题需要在过去二十年中设计的特定理论工具，以及应该实施的数据预处理程序，以避免这些实验技术固有的偏差。本文对这些统计工具和模型进行了综述。
英文摘要：
Tethered particle motion experiments are versatile single-molecule techniques enabling one to address in vitro the molecular properties of DNA and its interactions with various partners involved in genetic regulations. These techniques provide raw data such as the tracked particle amplitude of movement, from which relevant information about DNA conformations or states must be recovered. Solving this inverse problem appeals to specific theoretical tools that have been designed in the two last decades, together with the data pre-processing procedures that ought to be implemented to avoid biases inherent to these experimental techniques. These statistical tools and models are reviewed in this paper.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
