没有证据表明人类癫痫发作前的临界减速
No evidence for critical slowing down prior to human epileptic seizures
摘要：
目前正在辩论是否存在可适用于不同系统的关键转型通用预警信号。人类癫痫大脑通常被认为是一个原型系统，因为极端事件癫痫发作具有破坏性，有时甚至危及生命。30多年的国际努力已经成功地确定了即将缉获的预测因素。然而，适用于典型的预警指标的关键放缓，即方差和滞后1自相关，索引癫痫发作的易感性仍然是有争议的讨论。在这里，我们调查了28名癫痫患者的长期多通道脑动力学记录。使用基于代理人的评估程序的敏感性和特异性的时间分辨估计的早期预警指标，我们没有发现任何证据的关键放缓之前，105癫痫发作。
英文摘要：
There is a ongoing debate whether generic early warning signals for critical transitions exist that can be applied across diverse systems. The human epileptic brain is often considered as a prototypical system, given the devastating and, at times, even life-threatening nature of the extreme event epileptic seizure. More than three decades of international effort has successfully identified predictors of imminent seizures. However, the suitability of typically applied early warning indicators for critical slowing down, namely variance and lag-1 autocorrelation, for indexing seizure susceptibility is still controversially discussed. Here, we investigated long-term, multichannel recordings of brain dynamics from 28 subjects with epilepsy. Using a surrogate-based evaluation procedure of sensitivity and specificity of time-resolved estimates of early warning indicators, we found no evidence for critical slowing down prior to 105 epileptic seizures.
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