一种系统发育方法解开基因座间基因转换道长度和起始速率
A phylogenetic approach disentangles interlocus gene conversion tract length and initiation rate
摘要：
基因座间基因转换（IGC）使旁系同源物均质化。关于引起IGC的突变事件知之甚少，关于经历固定的IGC突变知之更少。为了解开固定IGC突变率从这些固定突变的道长度，我们采用复合似然程序。我们的特点与模拟的过程。我们将该程序应用于复制的灵长类内含子和酵母和灵长类动物的蛋白质编码旁系同源物。我们的估计从蛋白质编码数据的平均长度固定IGC束出乎意料地低，并与高度的不确定性。相比之下，我们从灵长类动物内含子数据的估计长度在IGC突变研究预期的一般范围内。虽然将固定IGC突变起始的速率与这些IGC事件影响的核苷酸位置的平均数分开是具有挑战性的，但我们所有的分析都表明IGC负责重复区域中相当大比例的进化变化。我们的研究结果表明，IGC应被认为是多基因家族的进化进行检查。
英文摘要：
Interlocus gene conversion (IGC) homogenizes paralogs. Little is known regarding the mutation events that cause IGC and even less is known about the IGC mutations that experience fixation. To disentangle the rates of fixed IGC mutations from the tract lengths of these fixed mutations, we employ a composite likelihood procedure. We characterize the procedure with simulations. We apply the procedure to duplicated primate introns and to protein-coding paralogs from both yeast and primates. Our estimates from protein-coding data concerning the mean length of fixed IGC tracts were unexpectedly low and are associated with high degrees of uncertainty. In contrast, our estimates from the primate intron data had lengths in the general range expected from IGC mutation studies. While it is challenging to separate the rate at which fixed IGC mutations initiate from the average number of nucleotide positions that these IGC events affect, all of our analyses indicate that IGC is responsible for a substantial proportion of evolutionary change in duplicated regions. Our results suggest that IGC should be considered whenever the evolution of multigene families is examined.
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