Uncertainty-Guided Domain Alignment for Layer Segmentation in OCT Images
School of Information Science and Engineering, Xiamen University（厦门大学信息科学与技术学院）；Tencent YouTu Lab（腾讯优图实验室）；State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University（中山大学中山眼科中心眼科学国家重点实验室）；Dept. of Computer Science and Engineering, The Chinese University of Hong Kong（香港中文大学计算机科学与工程学系）
Jiexiang Wang, Cheng Bian, Meng Li, Xin Yang, Kai Ma, Wenao Ma, Jin Yuan, Xinghao Ding, Yefeng Zheng
Automatic and accurate segmentation for retinal and choroidal layers of Optical Coherence Tomography (OCT) is crucial for detection of various ocular diseases. However, because of the variations in different equipments, OCT data obtained from different manufacturers might encounter appearance discrepancy, which could lead to performance fluctuation to a deep neural network. In this paper, we propose an uncertainty-guided domain alignment method to aim at alleviating this problem to transfer discriminative knowledge across distinct domains. We disign a novel uncertainty-guided cross-entropy loss for boosting the performance over areas with high uncertainty. An uncertainty-guided curriculum transfer strategy is developed for the self-training (ST), which regards uncertainty as efficient and effective guidance to optimize the learning process in target domain. Adversarial learning with feature recalibration module (FRM) is applied to transfer informative knowledge from the domain feature spaces adaptively. The experiments on two OCT datasets show that the proposed methods can obtain significant segmentation improvements compared with the baseline models.
Medical University of Vienna（维也纳医科大学）；Medical University Vienna（维也纳医科大学）
Optical coherence tomography (OCT) has become the most important imaging modality in ophthalmology. A substantial amount of research has recently been devoted to the development of machine learning (ML) models for the identification and quantification of pathological features in OCT images. Among the several sources of variability the ML models have to deal with, a major factor is the acquisition device, which can limit the ML model's generalizability. In this paper, we propose to reduce the image variability across different OCT devices (Spectralis and Cirrus) by using CycleGAN, an unsupervis…
3D imaging modalities are becoming increasingly popular and relevant in retinal imaging owing to their effectiveness in highlighting structures in sub-retinal layers. OCT is one such modality which has great importance in the context of analysis of cystoid structures in subretinal layers. Signal to noise ratio(SNR) of the images obtained from OCT is less and hence automated and accurate determination of cystoid structures from OCT is a challenging task. We propose an automated method for detecting/segmenting cysts in 3D OCT volumes. The proposed method is biologically inspired and fast aided b…
Enhancing Point Annotations with Superpixel and Confidence Learning Guided for Improving Semi-Supervised OCT Fluid Segmentation
Zhejiang Sci-Tech University（浙江理工大学）；Lishui University（丽水学院）；the Second Affiliated Hospital of Zhejiang University, College of Medicine（浙江大学医学院附属第二医院）；Communication University of Zhejiang（浙江传媒学院）；Hangzhou Dianzi University（杭州电子科技大学）；UT Southwestern Medical Center（德克萨斯大学西南医学中心）；Suzhou Research Institute of Shandong University（山东大学苏州研究院）
University of Heidelberg（海德堡大学）；Heidelberg Engineering GmbH（海德堡工程有限公司）
With the introduction of spectral-domain optical coherence tomography (OCT), resulting in a significant increase in acquisition speed, the fast and accurate segmentation of 3-D OCT scans has become evermore important. This paper presents a novel probabilistic approach, that models the appearance of retinal layers as well as the global shape variations of layer boundaries. Given an OCT scan, the full posterior distribution over segmentations is approximately inferred using a variational method enabling efficient probabilistic inference in terms of computationally tractable model components: Seg…
In this paper, we introduce a Bayesian deep learning based model for segmenting the photoreceptor layer in pathological OCT scans. Our architecture provides accurate segmentations of the photoreceptor layer and produces pixel-wise epistemic uncertainty maps that highlight potential areas of pathologies or segmentation errors. We empirically evaluated this approach in two sets of pathological OCT scans of patients with age-related macular degeneration, retinal vein oclussion and diabetic macular edema, improving the performance of the baseline U-Net both in terms of the Dice index and the area …
We overview the existing OCT work, especially the practical aspects of it. We create a novel algorithm for 3D OCT segmentation with the goals of speed and/or accuracy while remaining flexible in the design and implementation for future extensions and improvements. The document at this point is a running draft being iteratively "developed" as a progress report as the work and survey advance. It contains the review and summarization of select OCT works, the design and implementation of the OCTMARF experimentation application and some results.
University of Bern（伯尔尼大学）；RetinAI Medical GmbH（RetinAI Medical 公司）；Bern University Hospital（伯尔尼大学医院）
The automatic segmentation of retinal layer structures enables clinically-relevant quantification and monitoring of eye disorders over time in OCT imaging. Eyes with late-stage diseases are particularly challenging to segment, as their shape is highly warped due to pathological biomarkers. In this context, we propose a novel fully Convolutional Neural Network (CNN) architecture which combines dilated residual blocks in an asymmetric U-shape configuration, and can segment multiple layers of highly pathological eyes in one shot. We validate our approach on a dataset of late-stage AMD patients an…
University of Nottingham（诺丁汉大学）；Shenzhen University（深圳大学）；Wuhan University of Technology（武汉理工大学）；University of Leicester（莱斯特大学）
In this paper, we propose a novel retinal layer boundary model for segmentation of optical coherence tomography (OCT) images. The retinal layer boundary model consists of 9 open parametric contours representing the 9 retinal layers in OCT images. An intensity-based Mumford-Shah (MS) variational functional is first defined to evolve the retinal layer boundary model to segment the 9 layers simultaneously. By making use of the normals of open parametric contours, we construct equal sized adjacent narrowbands that are divided by each contour. Regional information in each narrowband can thus be int…
At the present time Optical Coherence Tomography (OCT) is among the most commonly used non-invasive imaging methods for the acquisition of large volumetric scans of human retinal tissues and vasculature. To resolve decisive information from extracted OCT volumes and to make it applicable for further diagnostic analysis, the exact identification of retinal layer thicknesses serves as an essential task be done for each patient separately. However, the manual examination of multiple OCT scans in a row is a demanding and time consuming task, which results in a lengthy qualification process and is …
SD-RetinaNet: Topologically Constrained Semi-Supervised Retinal Lesion and Layer Segmentation in OCT
Christian Doppler Laboratory for Artificial Intelligence in Retina（基督教多普勒人工智能视网膜实验室）；Institute of Artificial Intelligence（人工智能研究所）；Center for Medical Data Science（医学数据科学中心）；Medical University of Vienna（维也纳医学大学）；Computational Imaging Research Lab（计算成像研究实验室）；Department of Biomedical Imaging and Image-Guided Therapy（生物医学成像与影像引导治疗部门）；Department of Ophthalmology and Optometry（眼科与视光学部门）
LUMOS: Universal Semi-Supervised OCT Retinal Layer Segmentation with Hierarchical Reliable Mutual Learning
Southern University of Science and Technology（南方科技大学）；Shenzhen Loop Area Institute（深圳河套学院）；Jiaxing Research Institute, Southern University of Science and Technology（南方科技大学嘉兴研究院）
With the introduction of spectral-domain optical coherence tomography (SDOCT), much larger image datasets are routinely acquired compared to what was possible using the previous generation of time-domain OCT. Thus, there is a critical need for the development of 3D segmentation methods for processing these data. We present here a novel 3D automatic segmentation method for retinal OCT volume data. Briefly, to segment a boundary surface, two OCT volume datasets are obtained by using a 3D smoothing filter and a 3D differential filter. Their linear combination is then calculated to generate new vo…
IBM Research - Australia（IBM澳大利亚研究院）；NYU Langone Eye Center（纽约大学兰贡眼科中心）；NYU School of Medicine（纽约大学医学院）
Deep convolutional neural networks have shown outstanding performance in medical image segmentation tasks. The usual problem when training supervised deep learning methods is the lack of labeled data which is time-consuming and costly to obtain. In this paper, we propose a novel uncertainty-guided semi-supervised learning based on a student-teacher approach for training the segmentation network using limited labeled samples and a large number of unlabeled images. First, a teacher segmentation model is trained from the labeled samples using Bayesian deep learning. The trained model is used to g…
Bilkent University（比尔肯特大学）；Koc University School of Medicine（科克大学医学院）；Koc University（科克大学）
The Henle's fiber layer (HFL) in the retina carries valuable information on the macular condition of an eye. However, in the common practice, this layer is not separately segmented but rather included in the outer nuclear layer since it is difficult to perceive HFL contours on standard optical coherence tomography (OCT) imaging. Due to its variable reflectivity under an imaging beam, delineating the HFL contours necessitates directional OCT, which requires additional imaging. This paper addresses this issue by introducing a shape-preserving network, FourierNet, that achieves HFL segmentation i…
Nanjing University of Science and Technology（南京理工大学）
Optical coherence tomography angiography (OCTA) is a novel imaging modality that has been widely utilized in ophthalmology and neuroscience studies to observe retinal vessels and microvascular systems. However, publicly available OCTA datasets remain scarce. In this paper, we introduce the largest and most comprehensive OCTA dataset dubbed OCTA-500, which contains OCTA imaging under two fields of view (FOVs) from 500 subjects. The dataset provides rich images and annotations including two modalities (OCT/OCTA volumes), six types of projections, four types of text labels (age / gender / eye / d…
Retinal Layer Segmentation in OCT Images With 2.5D Cross-slice Feature Fusion Module for Glaucoma Assessment
Department of Mechanical Engineering, Yonsei University, Seoul, 03722, South Korea（延世大学机械工程系）；Institute of Vision Research, Department of Ophthalmology, Severance Hospital, Yonsei University, Seoul, 03722, South Korea（视觉研究所眼科部, 顺化医院, 延世大学, 首尔, 03722, 韩国）；Yonsei University College of Medicine, Seoul, 03722, South Korea（延世大学医学院）
Multiple-surface segmentation in Optical Coherence Tomography (OCT) images is a challenge problem, further complicated by the frequent presence of weak image boundaries. Recently, many deep learning (DL) based methods have been developed for this task and yield remarkable performance. Unfortunately, due to the scarcity of training data in medical imaging, it is challenging for DL networks to learn the global structure of the target surfaces, including surface smoothness. To bridge this gap, this study proposes to seamlessly unify a U-Net for feature learning with a constrained differentiable d…
Optical coherence tomography (OCT) is a non-invasive imaging technique widely used for ophthalmology. It can be extended to OCT angiography (OCT-A), which reveals the retinal vasculature with improved contrast. Recent deep learning algorithms produced promising vascular segmentation results; however, 3D retinal vessel segmentation remains difficult due to the lack of manually annotated training data. We propose a learning-based method that is only supervised by a self-synthesized modality named local intensity fusion (LIF). LIF is a capillary-enhanced volume computed directly from the input OC…
Segmentation of retinal layers from Optical Coherence Tomography (OCT) volumes is a fundamental problem for any computer aided diagnostic algorithm development. This requires preprocessing steps such as denoising, region of interest extraction, flattening and edge detection all of which involve separate parameter tuning. In this paper, we explore deep learning techniques to automate all these steps and handle the presence/absence of pathologies. A model is proposed consisting of a combination of Convolutional Neural Network (CNN) and Long Short Term Memory (LSTM). The CNN is used to extract la…
Portland State University（波特兰州立大学）；Wilmer Eye Institute（威尔默眼科研究所）；The Johns Hopkins University（约翰斯·霍普金斯大学）；The Johns Hopkins University School of Medicine（约翰斯·霍普金斯大学医学院）
Optical coherence tomography (OCT) is a noninvasive imaging modality which can be used to obtain depth images of the retina. The changing layer thicknesses can thus be quantified by analyzing these OCT images, moreover these changes have been shown to correlate with disease progression in multiple sclerosis. Recent automated retinal layer segmentation tools use machine learning methods to perform pixel-wise labeling and graph methods to guarantee the layer hierarchy or topology. However, graph parameters like distance and smoothness constraints must be experimentally assigned by retinal region…
In medical imaging, there are clinically relevant segmentation tasks where the output mask is a projection to a subset of input image dimensions. In this work, we propose a novel convolutional neural network architecture that can effectively learn to produce a lower-dimensional segmentation mask than the input image. The network restores encoded representation only in a subset of input spatial dimensions and keeps the representation unchanged in the others. The newly proposed projective skip-connections allow linking the encoder and decoder in a UNet-like structure. We evaluated the proposed m…
Tencent Jarvis Lab, Tencent（腾讯杰维斯实验室，腾讯）；National University of Defense Technology（国防科技大学）
Primary angle closure glaucoma (PACG) is the leading cause of irreversible blindness among Asian people. Early detection of PACG is essential, so as to provide timely treatment and minimize the vision loss. In the clinical practice, PACG is diagnosed by analyzing the angle between the cornea and iris with anterior segment optical coherence tomography (AS-OCT). The rapid development of deep learning technologies provides the feasibility of building a computer-aided system for the fast and accurate segmentation of cornea and iris tissues. However, the application of deep learning methods in the …
Cixi Institute of Biomedical Engineering, Ningbo Institute of Industrial Technology, Chinese Academy of Sciences（中国科学院宁波工业技术研究院慈溪生物医学工程研究所）；Inception Institute of Artificial Intelligence（起源人工智能研究院）；Keck School of Medicine, University of Southern California（南加州大学凯克医学院）；First Affiliated Hospital of Wenzhou Medical University（温州医科大学附属第一医院）；Southern University of Science and Technology（南方科技大学）；University of Liverpool（利物浦大学）
Optical Coherence Tomography Angiography (OCT-A) is a non-invasive imaging technique, and has been increasingly used to image the retinal vasculature at capillary level resolution. However, automated segmentation of retinal vessels in OCT-A has been under-studied due to various challenges such as low capillary visibility and high vessel complexity, despite its significance in understanding many eye-related diseases. In addition, there is no publicly available OCT-A dataset with manually graded vessels for training and validation. To address these issues, for the first time in the field of reti…
Automated surface segmentation of retinal layer is important and challenging in analyzing optical coherence tomography (OCT). Recently, many deep learning based methods have been developed for this task and yield remarkable performance. However, due to large spatial gap and potential mismatch between the B-scans of OCT data, all of them are based on 2D segmentation of individual B-scans, which may loss the continuity information across the B-scans. In addition, 3D surface of the retina layers can provide more diagnostic information, which is crucial in quantitative image analysis. In this stud…
Casey Eye Institute, Oregon Health & Science University（俄勒冈健康与科学大学凯西眼科研究所）；School of Physics and Optoelectronic Engineering, Foshan University（佛山大学物理与光电工程学院）；Department of Biomedical Engineering, Oregon Health & Science University（俄勒冈健康与科学大学生物医学工程系）
Purpose: We proposed a deep convolutional neural network (CNN), named Retinal Fluid Segmentation Network (ReF-Net) to segment volumetric retinal fluid on optical coherence tomography (OCT) volume. Methods: 3 x 3-mm OCT scans were acquired on one eye by a 70-kHz OCT commercial AngioVue system (RTVue-XR; Optovue, Inc.) from 51 participants in a clinical diabetic retinopathy (DR) study (45 with retinal edema and 6 healthy controls). A CNN with U-Net-like architecture was constructed to detect and segment the retinal fluid. Cross-sectional OCT and angiography (OCTA) scans were used for training an…
This paper presents a novel automated system that segments six sub-retinal layers from optical coherence tomography (OCT) image stacks of healthy patients and patients with diabetic macular edema (DME). First, each image in the OCT stack is denoised using a Wiener deconvolution algorithm that estimates the additive speckle noise variance using a novel Fourier-domain based structural error. This denoising method enhances the image SNR by an average of 12dB. Next, the denoised images are subjected to an iterative multi-resolution high-pass filtering algorithm that detects seven sub-retinal surfa…
Deep learning models, such as the fully convolutional network (FCN), have been widely used in 3D biomedical segmentation and achieved state-of-the-art performance. Multiple modalities are often used for disease diagnosis and quantification. Two approaches are widely used in the literature to fuse multiple modalities in the segmentation networks: early-fusion (which stacks multiple modalities as different input channels) and late-fusion (which fuses the segmentation results from different modalities at the very end). These fusion methods easily suffer from the cross-modal interference caused by…
PC-Seg: Progressive Cross-View Consistency for 3D OCT Segmentation from Sparse 2D Annotations
Graduate School of Information Sciences, Tohoku University（东北大学信息科学研究生院）；Department of Ophthalmology, Graduate School of Medicine, Tohoku University（东北大学医学研究生院眼科系）；Institute of Ophthalmology, University College London（伦敦大学学院眼科研究所）；NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust（摩尔菲尔德眼科医院NHS基金会信托基金NIHR生物医学研究中心）；UCL Hawkes Institute, University College London（伦敦大学学院UCL霍克斯研究所）；Department of Computer Science, University College London（伦敦大学学院计算机科学系）
In this paper we present a new method for cystoid macular edema (CME) segmentation in retinal Optical Coherence Tomography (OCT) images, using a fully convolutional neural network (FCN) and a fully connected conditional random fields (dense CRFs). As a first step, the framework trains the FCN model to extract features from retinal layers in OCT images, which exhibit CME, and then segments CME regions using the trained model. Thereafter, dense CRFs are used to refine the segmentation according to the edema appearance. We have trained and tested the framework with OCT images from 10 patients wit…
Defect Segmentation in OCT scans of ceramic parts for non-destructive inspection using deep learning
Instituto Universitario de Investigación en Tecnología Centrada en el Ser Humano, Universitat Politècnica de València, Valencia, Spain Department of Electrical；Photonics Engineering, Technical University of Denmark, Kongens Lyngby, Denmark NORBLIS ApS, Virum, Denmark Lithoz GmbH, Vienna, Austria airCode UG, Duisburg, Germany
Optical coherence tomography (OCT) is commonly used to analyze retinal layers for assessment of ocular diseases. In this paper, we propose a method for retinal layer segmentation and quantification of uncertainty based on Bayesian deep learning. Our method not only performs end-to-end segmentation of retinal layers, but also gives the pixel wise uncertainty measure of the segmentation output. The generated uncertainty map can be used to identify erroneously segmented image regions which is useful in downstream analysis. We have validated our method on a dataset of 1487 images obtained from 15 …
Bruch's membrane (BM) segmentation on optical coherence tomography (OCT) is a pivotal step for the diagnosis and follow-up of age-related macular degeneration (AMD), one of the leading causes of blindness in the developed world. Automated BM segmentation methods exist, but they usually do not account for the anatomical coherence of the results, neither provide feedback on the confidence of the prediction. These factors limit the applicability of these systems in real-world scenarios. With this in mind, we propose an end-to-end deep learning method for automated BM segmentation in AMD patients.…
School of Automation Science and Electrical Engineering, Beihang University (BUAA)（北京航空航天大学自动化科学与电气工程学院）；Khalifa University of Science & Technology（哈利法科技大学）；School of Computer and Communication Engineering, University of Science & Technology Beijing（北京科技大学计算机与通信工程学院）；School of Electrical Engineering and Intelligentization, Dongguan University of Technology（东莞理工学院电气工程与智能化学院）
This paper proposes an automated method for the segmentation and extraction of the posterior segment of the human eye, including the vitreous, retina, choroid, and sclera compartments, using multi-vendor optical coherence tomography (OCT) scans. The proposed method works in two phases. First extracts the retinal pigment epithelium (RPE) layer by applying the adaptive thresholding technique to identify the retina-choroid junction. Then, it exploits the structure tensor guided approach to extract the inner limiting membrane (ILM) and the choroidal stroma (CS) layers, locating the vitreous-retina…
Text-Driven Weakly Supervised OCT Lesion Segmentation with Structural Guidance
CUNY Graduate Center（CUNY研究生中心）；New York University Department of Ophthalmology（纽约大学眼科系）；NYU Langone Health（NYU兰格one健康）；Massachusetts General Hospital and Harvard Medical School（麻省总医院和哈佛医学院）；Stony Brook University（石溪大学）
University of Isfahan（伊斯法罕大学）；Duke University（杜克大学）；Duke University Medical Center（杜克大学医学中心）
Optical coherence tomography (OCT) helps ophthalmologists assess macular edema, accumulation of fluids, and lesions at microscopic resolution. Quantification of retinal fluids is necessary for OCT-guided treatment management, which relies on a precise image segmentation step. As manual analysis of retinal fluids is a time-consuming, subjective, and error-prone task, there is increasing demand for fast and robust automatic solutions. In this study, a new convolutional neural architecture named RetiFluidNet is proposed for multi-class retinal fluid segmentation. The model benefits from hierarchi…
Grading of cancer is important to know the extent of its spread. Prior to grading, segmentation of glandular structures is important. Manual segmentation is a time consuming process and is subject to observer bias. Hence, an automated process is required to segment the gland structures. These glands show a large variation in shape size and texture. This makes the task challenging as the glands cannot be segmented using mere morphological operations and conventional segmentation mechanisms. In this project we propose a method which detects the boundary epithelial cells of glands and then a nove…
Simon Fraser University（西蒙菲莎大学）；University of British Columbia（不列颠哥伦比亚大学）；University of Western Australia（西澳大学）；Lions Eye Institute（狮子眼科研究所）；Vitreous Retina Macula Consultants of New York（纽约玻璃体视网膜黄斑 Consultants）；Manhattan Eye, Ear and Throat Hospital（曼哈顿眼耳鼻喉医院）；University of Zagreb（萨格勒布大学）
Automatic quantification of perifoveal vessel densities in optical coherence tomography angiography (OCT-A) images face challenges such as variable intra- and inter-image signal to noise ratios, projection artefacts from outer vasculature layers, and motion artefacts. This study demonstrates the utility of deep neural networks for automatic quantification of foveal avascular zone (FAZ) parameters and perifoveal vessel density of OCT-A images in healthy and diabetic eyes. OCT-A images of the foveal region were acquired using three OCT-A systems: a 1060nm Swept Source (SS)-OCT prototype, RTVue X…
Medical University of Vienna（维也纳医科大学）；University of Vienna（维也纳大学）
Segmenting anatomical structures such as the photoreceptor layer in retinal optical coherence tomography (OCT) scans is challenging in pathological scenarios. Supervised deep learning models trained with standard loss functions are usually able to characterize only the most common disease appeareance from a training set, resulting in suboptimal performance and poor generalization when dealing with unseen lesions. In this paper we propose to overcome this limitation by means of an augmented target loss function framework. We introduce a novel amplified-target loss that explicitly penalizes erro…
Shahid Beheshti University（沙希德·贝赫什提大学）；Shahid Beheshti University of Medical Sciences（沙希德·贝赫什提医科大学）
Intra retinal fluids or Cysts are one of the important symptoms of macular pathologies that are efficiently visualized in OCT images. Automatic segmentation of these abnormalities has been widely investigated in medical image processing studies. In this paper, we propose a new U-Net-based approach for Intra retinal cyst segmentation across different vendors that improves some of the challenges faced by previous deep-based techniques. The proposed method has two main steps: 1- prior information embedding and input data adjustment, and 2- IRC segmentation model. In the first step, we inject the …
University of Oxford（牛津大学）；Big Data Institute, University of Oxford（牛津大学大数据研究所）；School of Engineering, Newcastle University（纽卡斯尔大学工程学院）；Neura Health Group；Newcastle Eye Centre, Royal Victoria Infirmary（纽卡斯尔皇家维多利亚医院纽卡斯尔眼科中心）；Newcastle University（纽卡斯尔大学）；Newcastle Upon Tyne, UK（泰恩河畔纽卡斯尔（英国））
Optical coherence tomography (OCT) is a commonly-used method of extracting high resolution retinal information. Moreover there is an increasing demand for the automated retinal layer segmentation which facilitates the retinal disease diagnosis. In this paper, we propose a novel multiprediction guided attention network (MPG-Net) for automated retinal layer segmentation in OCT images. The proposed method consists of two major steps to strengthen the discriminative power of a U-shape Fully convolutional network (FCN) for reliable automated segmentation. Firstly, the feature refinement module whic…
Simultaneous Alignment and Surface Regression Using Hybrid 2D-3D Networks for 3D Coherent Layer Segmentation of Retinal OCT Images with Full and Sparse Annotations
Xiamen University（厦门大学）；National Institute for Data Science in Health and Medicine, Xiamen University（厦门大学健康医疗大数据国家研究院）；Tencent YouTu Lab（腾讯优图实验室）；Southern University of Science and Technology（南方科技大学）
Optical coherence tomography (OCT) is a non-invasive 3D modality widely used in ophthalmology for imaging the retina. Achieving automated, anatomically coherent retinal layer segmentation on OCT is important for the detection and monitoring of different retinal diseases, like Age-related Macular Disease (AMD) or Diabetic Retinopathy. However, the majority of state-of-the-art layer segmentation methods are based on purely supervised deep-learning, requiring a large amount of pixel-level annotated data that is expensive and hard to obtain. With this in mind, we introduce a semi-supervised paradi…
With the introduction of spectral-domain optical coherence tomography (OCT), much larger image datasets are routinely acquired compared to what was possible using the previous generation of time-domain OCT. Thus, the need for 3-D segmentation methods for processing such data is becoming increasingly important. We present a new 3D segmentation method for retinal OCT volume data, which generates an enhanced volume data by using pixel intensity, boundary position information, intensity changes on both sides of the border simultaneously, and preliminary discrete boundary points are found from all …
Technical University of Munich（慕尼黑工业大学）；Johns Hopkins University（约翰斯·霍普金斯大学）
Automated segmentation of retinal optical coherence tomography (OCT) images has become an important recent direction in machine learning for medical applications. We hypothesize that the anatomic structure of layers and their high-frequency variation in OCT images make retinal OCT a fitting choice for extracting spectral-domain features and combining them with spatial domain features. In this work, we present $Υ$-Net, an architecture that combines the frequency domain features with the image domain to improve the segmentation performance of OCT images. The results of this work demonstrate that…
Denoising, segmentation and volumetric rendering of optical coherence tomography angiography (OCTA) image using deep learning techniques: a review
Department of Mechanical and Electronic Engineering, Kunming University of Science and Technology（昆明理工大学机械电子工程系）；Eye Clinics, Yunnan First People's Hospital（云南第一人民医院眼科）
Vidyasirimedhi Institute of Science & Technology（维迪亚西里梅迪科技学院）；Kamnoetvidya Science Academy（卡姆诺维迪亚科学学院）；Ningbo Institute of Industrial Technology, Chinese Academy of Sciences（中国科学院宁波工业技术研究院）；Cixi Institute of Biomedical Engineering（慈溪生物医学工程研究所）；Kasetsart University（泰国农业大学）；Nanyang Technological University（南洋理工大学）
While there have been increased researches using deep learning techniques for the extraction of vascular structure from the 2D en face OCTA, for such approach, it is known that the data annotation process on the curvilinear structure like the retinal vasculature is very costly and time consuming, albeit few tried to address the annotation problem. In this work, we propose the application of the scribble-base weakly-supervised learning method to automate the pixel-level annotation. The proposed method, called OCTAve, combines the weakly-supervised learning using scribble-annotated ground truth …
Ophthalmic Engineering and Innovation Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore（新加坡国立大学工程学院生物医学工程系眼科工程与创新实验室）；Singapore Eye Research Institute, Singapore National Eye Centre（新加坡国立眼科中心新加坡眼科研究所）；Rajan Eye Care Hospital（拉詹眼科护理医院）
Since the introduction of optical coherence tomography (OCT), it has been possible to study the complex 3D morphological changes of the optic nerve head (ONH) tissues that occur along with the progression of glaucoma. Although several deep learning (DL) techniques have been recently proposed for the automated extraction (segmentation) and quantification of these morphological changes, the device specific nature and the difficulty in preparing manual segmentations (training data) limit their clinical adoption. With several new manufacturers and next-generation OCT devices entering the market, t…
