Onset detection: A new approach to QBH system

Bayesian detection of embryonic gene expression onset in C. elegans

To study how a zygote develops into an embryo with different tissues, large-scale 4D confocal movies of C. elegans embryos have been produced recently by experimental biologists. However, the lack of principled statistical methods for the highly noisy data has hindered the comprehensive analysis of these data sets. We introduced a probabilistic change point model on the cell lineage tree to estimate the embryonic gene expression onset time. A Bayesian approach is used to fit the 4D confocal movies data to the model. Subsequent classification methods are used to decide a model selection thresho…

Robust Unsupervised Transient Detection With Invariant Representation based on the Scattering Network

We present a sparse and invariant representation with low asymptotic complexity for robust unsupervised transient and onset zone detection in noisy environments. This unsupervised approach is based on wavelet transforms and leverages the scattering network from Mallat et al. by deriving frequency invariance. This frequency invariance is a key concept to enforce robust representations of transients in presence of possible frequency shifts and perturbations occurring in the original signal. Implementation details as well as complexity analysis are provided in addition of the theoretical framewor…

早期疾病发病预测中数据集偏移问题的分布外弃权（不执行）选项方法

Out-of-distribution Reject Option Method for Dataset Shift Problem in Early Disease Onset Prediction

针对早期疾病预测中的数据集偏移问题，提出ODROP方法，集成OOD检测模型以排除分布外数据，在真实健康检查数据上显著提升AUROC，首次将OOD检测应用于实际医疗数据。

Early detection of sepsis utilizing deep learning on electronic health record event sequences

The timeliness of detection of a sepsis event in progress is a crucial factor in the outcome for the patient. Machine learning models built from data in electronic health records can be used as an effective tool for improving this timeliness, but so far the potential for clinical implementations has been largely limited to studies in intensive care units. This study will employ a richer data set that will expand the applicability of these models beyond intensive care units. Furthermore, we will circumvent several important limitations that have been found in the literature: 1) Models are evalu…

A Change Dynamic Model for the Online Detection of Gradual Change

Changes in the statistical properties of a stochastic process are typically assumed to occur via change-points, which demark instantaneous moments of complete and total change in process behavior. In cases where these transitions occur gradually, this assumption can result in a reduced ability to properly identify and respond to process change. With this observation in mind, we introduce a novel change-dynamic model for the online detection of gradual change in a Bayesian framework, in which change-points are used within a hierarchical model to indicate moments of gradual change onset or termi…