实验室偏见阻碍了生态-进化-发展的整合：来自微观世界的提示
Laboratory biases hinder Eco-Evo-Devo integration: hints from the microworld
摘要：
特定的环境背景如何有助于发展轨迹和进化转型的稳健性和变化是生态进化发展的中心点。然而，生态，进化和发展过程的衔接到综合框架一直难以捉摸，部分原因是标准的实验设计忽视或过度简化生态意义的背景。微生物模型可用于揭示和讨论与基因为中心的实验设计相关的两种可能的偏倚来源：实验室菌株的使用和实验室环境条件。我们说明了我们的观点，显示对比的发育表型在粘球菌xanthus取决于温度和基板刚度的联合变化。微生物发育可以提供关键信息，更好地了解环境条件在发育变异的演变中的作用，并克服与当前实验方法相关的一些局限性。
英文摘要：
How specific environmental contexts contribute to the robustness and variation of developmental trajectories and evolutionary transitions is a central point in Eco-Evo-Devo. However, the articulation of ecological, evolutionary and developmental processes into integrative frameworks has been elusive, partly because standard experimental designs neglect or oversimplify ecologically meaningful contexts. Microbial models are useful to expose and discuss two possible sources of bias associated with gene-centered experimental designs: the use of laboratory strains and laboratory environmental conditions. We illustrate our point by showing how contrasting developmental phenotypes in Myxococcus xanthus depend on the joint variation of temperature and substrate stiffness. Microorganismal development can provide key information for better understanding the role of environmental conditions in the evolution of developmental variation, and to overcome some of the limitations associated with current experimental approaches.
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