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arXiv 1908.01901cs.LGeess.IVstat.ML

Fully-automated patient-level malaria assessment on field-prepared thin blood film microscopy images, including Supplementary Information

Intellectual Ventures/Global Good Research(高智公司/全球好研究部);IBM(国际商业机器公司);Arizona State U.(亚利桑那州立大学);Creative Creek LLC(创意溪有限责任公司);LSHTM(伦敦卫生与热带医学院);SMRU(湄公河疟疾研究组);UPCH(秘鲁卡耶塔诺·埃雷迪亚大学);HTD(医院热带病科(英国伦敦));Amref(非洲医学研究基金会);WWARN(世界抗疟耐药性监测网络);Kemri(肯尼亚医学研究所);U. Lagos(拉各斯大学);DSMA(国防医学科学院(缅甸))
Charles B. Delahunt, Mayoore S. Jaiswal, Matthew P. Horning, Samantha Janko, Clay M. Thompson, Sourabh Kulhare, Liming Hu, Travis Ostbye, Grace Yun, Roman Gebre… 展开作者

Charles B. Delahunt, Mayoore S. Jaiswal, Matthew P. Horning, Samantha Janko, Clay M. Thompson, Sourabh Kulhare, Liming Hu, Travis Ostbye, Grace Yun, Roman Gebrehiwot, Benjamin K. Wilson, Earl Long, Stephane Proux, Dionicia Gamboa, Peter Chiodini, Jane Carter, Mehul Dhorda, David Isaboke, Bernhards Ogutu, Wellington Oyibo, Elizabeth Villasis, Kyaw Myo Tun, Christine Bachman, David Bell, Courosh Mehanian

英文摘要:

Malaria is a life-threatening disease affecting millions. Microscopy-based assessment of thin blood films is a standard method to (i) determine malaria species and (ii) quantitate high-parasitemia infections. Full automation of malaria microscopy by machine learning (ML) is a challenging task because field-prepared slides vary widely in quality and presentation, and artifacts often heavily outnumber relatively rare parasites. In this work, we describe a complete, fully-automated framework for thin film malaria analysis that applies ML methods, including convolutional neural nets (CNNs), trained on a large and diverse dataset of field-prepared thin blood films. Quantitation and species identification results are close to sufficiently accurate for the concrete needs of drug resistance monitoring and clinical use-cases on field-prepared samples. We focus our methods and our performance metrics on the field use-case requirements. We discuss key issues and important metrics for the application of ML methods to malaria microscopy.

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