毛细管糖萼介导的仿生微血管流动电位
Streaming Potential in Bio-mimetic Microvessels Mediated by Capillary Glycocalyx
摘要：
植入式医疗设备和生物传感器通过在疾病检测和治疗领域开辟新的维度，在医疗技术领域的革命中发挥着关键作用。这些设备需要利用生物相容性和生理上可持续的安全电源，而不是依赖于外部刺激，克服其体内适用性的限制。在这里，通过呼吁在生理相关的微血管中的电动力学和流体动力学的相互作用，我们带出的作用，带电的内皮糖萼层（EGL）建立跨生理流体管道的流动电位。我们考虑到血液模拟流体的复杂流变学呼吁牛顿流体模型代表血浆和粘弹性流体模型代表全血。我们模拟的EGL作为一个多孔弹性层与体积电荷分布。我们的研究结果表明，对于生理相关的微流，诱导的流动电位通常为0.1 V/mm的量级，这可能会对激励生物传感器和植入式医疗设备产生重大影响，其功率要求通常在微瓦至毫瓦的范围内。我们还提出了具体的影响，相关的生理参数对建立的流动潜力，增加了合理的功能范围内相同的愿景。我们进一步揭示了EGL厚度对流动电位的依赖性可能是解开血管生成模式背后奥秘的关键方面之一。我们的研究结果可能会开辟新的生物传感和驱动的可能性，在医疗诊断，以及可能提供一个可能的替代方案，关于在人体内的生理安全和生物相容性电源的发展。
英文摘要：
Implantable medical devices and biosensors are pivotal in revolutionizing the field of medical technology by opening new dimensions in the field of disease detection and cure. These devices need to harness a biocompatible and physiologically sustainable safe power source instead of relying on external stimuli, overcoming the constraints on their applicability in-vivo. Here, by appealing to the interplay of electromechanics and hydrodynamics in physiologically relevant microvessels, we bring out the role of charged Endothelial Glycocalyx layer (EGL) towards establishing a streaming potential across physiological fluidic conduits. We account for the complex rheology of blood-mimicking fluid by appealing to Newtonian fluid model representing the blood plasma and a viscoelastic fluid model representing the whole blood. We model the EGL as a poroelastic layer with volumetric charge distribution. Our results reveal that for physiologically relevant microflows, the streaming potential induced is typically of the order of 0.1 V/mm, which may turn out to be substantial towards energizing biosensors and implantable medical devices whose power requirements are typically in the range of micro to milli Watt. We also bring out the specific implications of the relevant physiological parameters towards establishment of the streaming potential, with a vision of augmenting the same within plausible functional limits. We further unveil that the dependence of streaming potential on EGL thickness might be one of the key aspects in unlocking the mystery behind the angiogenesis pattern. Our results may open up novel bio-sensing and actuating possibilities in medical diagnostics as well as may provide a possible alternative regarding the development of physiologically safe and biocompatible power sources within the human body.
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