核糖体竞争的平衡模型
An equilibrium model for ribosome competition
摘要：
细胞中核糖体的数量被认为是有限的，因此基因表达在很大程度上取决于它们的细胞浓度。在这项工作中，我们开发了一个玩具模型来研究核糖体供应和翻译机器的需求之间的权衡，由转录池的组成。我们的平衡框架是有用的，以突出定性行为和新的手段，基因表达调控所确定的这种权衡的精细平衡。我们还推测这些机制对细胞生理学的可能影响。
英文摘要：
The number of ribosomes in a cell is considered as limiting, and gene expression is thus largely determined by their cellular concentration. In this work we develop a toy model to study the trade-off between the ribosomal supply and the demand of the translation machinery, dictated by the composition of the transcript pool. Our equilibrium framework is useful to highlight qualitative behaviours and new means of gene expression regulation determined by the fine balance of this trade-off. We also speculate on the possible impact of these mechanisms on cellular physiology.
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