内在噪声、Delta-Notch信号和延迟反应促进了前体中胚层持续、连贯、同步的振荡
Intrinsic noise, Delta-Notch signalling and delayed reactions promote sustained, coherent, synchronised oscillations in the presomitic mesoderm
摘要：
使用一个随机的个人为基础的建模方法，我们研究的作用，三角洲缺口信号在一个强大的和可靠的体节分割时钟的调节。我们发现，Delta-Notch信号不仅可以同步化前体中胚层相邻细胞中基因表达的嘈杂周期（如已知的），而且还可以放大和增加这些周期的连贯性。我们研究了确定性方法来模拟这些周期的一些缺点，并演示了固有噪声如何在促进持续振荡中发挥积极作用，从而产生噪声引起的准周期。最后，我们探讨如何翻译/转录延迟可能会导致在相邻细胞的周期振荡反相，我们研究这种影响如何与噪声引起的随机波的传播。
英文摘要：
Using a stochastic individual-based modelling approach, we examine the role that Delta-Notch signalling plays in the regulation of a robust and reliable somite segmentation clock. We find that not only can Delta-Notch signalling synchronise noisy cycles of gene expression in adjacent cells in the presomitic mesoderm (as is known), but it can also amplify and increase the coherence of these cycles. We examine some of the shortcomings of deterministic approaches to modelling these cycles and demonstrate how intrinsic noise can play an active role in promoting sustained oscillations, giving rise to noise-induced quasi-cycles. Finally, we explore how translational/transcriptional delays can result in the cycles in neighbouring cells oscillating in anti-phase and we study how this effect relates to the propagation of noise-induced stochastic waves.
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