人类角膜缘的平均形状
Mean shape of the human limbus
摘要：
目的：描述正常人眼角膜缘的平均地形形状，并确定其是否取决于年龄和屈光力。设置：学术机构。设计：前瞻性病例系列。方法：74例年龄20 ~ 84岁，无眼部手术史的患者纳入本研究。用角膜巩膜地形图仪（眼表面轮廓仪）测量左眼四次。根据每次测量的原始前眼高度数据，对地形角膜缘进行划界，并在三维空间中拟合成圆、椭圆和傅立叶级数。计算均方根误差（RMSE）以评价拟合的拟合优度。此外，从测量装置的读数中获取白至白（WTW）角膜直径，并与角膜缘地形图进行比较。为了进行统计分析，将受试者分组为年轻和老年，并根据其等效球镜矫正。结果：从所考虑的模型，二阶傅立叶级数导致在最准确的模型来描述的形状的人的角膜缘。角膜缘地形图直径与WTW角膜直径之差平均为0.33 mm，标准差为0.24 mm，眼象限间差异有统计学意义，水平子午线和垂直子午线年龄组间差异无统计学意义结论：人的角膜缘是不对称的，其形状与年龄和屈光力无关，但与年龄和屈光力有关。
英文摘要：
Purpose: To characterize the mean topographical shape of the human limbus of a normal eye and ascertain whether it depends on age and refractive power. Setting: Academic institution. Design: Prospective case series. Methods: 74 subjects aged from 20 to 84 years and with no previous ocular surgeries were included in this study. The left eye was measured four times with a corneo scleral topographer (Eye Surface Profiler). From the raw anterior eye height data of each measurement, topographical limbus was demarcated and fitted in three dimensions to a circle, an ellipse and a Fourier series. Root mean square error (RMSE) was calculated to evaluate the goodness of fit. In addition, white to white (WTW) corneal diameter was taken from the readings of the measuring device and compared with the topographical limbus. For statistical analysis, subjects were grouped as young and older, and also according their equivalent sphere correction. Results: From the considered models, second order Fourier series resulted in the most accurate model to describe the shape of the human limbus. The difference between the topographical limbus diameter and the WTW corneal diameter amounted on average and standard deviation to 0.33 mm and 0.24 mm. Statistically significant differences among eye quadrants were found. No statistically significant difference in horizontal and vertical meridian between age groups (P=0.71 and P=0.082, respectively) or between myopes and emmetropes (P=0.78 and P=0.68, respectively) were found. Conclusions: Human limbus is not symmetrical and its shape is subject dependent but not related to age and eye refractive power.
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