红细胞变形与动力学决定其通过具有确定性侧向位移架构的微流控器件
Deformation and dynamics of erythrocytes govern their traversal through microfluidic devices with a deterministic lateral displacement architecture
AI总结：
本研究通过介观流体动力学模拟，揭示了红细胞在确定性侧向位移微流控器件中的变形与动力学行为，构建了细胞行为模式图并阐明了分选机制，指出基于剪切弹性的红细胞分选需精细调节流动条件。
摘要：
确定性侧向位移（DLD）微流控器件有望实现对生物样品的多功能且精确的处理。然而，这一前景迄今为止仅针对刚性球形粒子得以实现，由于微流控流动中细胞动力学与变形的复杂性，对于生物细胞而言仍受限。我们采用介观流体动力学模拟，研究了具有圆形柱的 DLD 器件中的红细胞（RBC），以更好地理解复杂微流控流动中细胞行为与此类器件分选能力之间的相互作用。我们构建了 RBC 行为的模式图（例如位移、锯齿形和中间模式），并确定了 RBC 动力学的几种状态（例如翻滚、坦克履带式运动和三叶运动）。此外，我们将 RBC 与柱之间的复杂相互作用动力学与其有效细胞尺寸联系起来，并讨论了支配动态细胞状态的相关物理机制。总之，基于剪切弹性在 DLD 器件中对 RBC 进行分选通常是可行的，但需要对流动条件进行精细调节以匹配 RBC 的目标力学性质。
英文摘要：
Deterministic lateral displacement (DLD) microfluidic devices promise versatile and precise processing of biological samples. However, this prospect has been realized so far only for rigid spherical particles and remains limited for biological cells due to the complexity of cell dynamics and deformation in microfluidic flow. We employ mesoscopic hydrodynamics simulations of red blood cells (RBC) in DLD devices with circular posts to better understand the interplay between cell behavior in complex microfluidic flow and sorting capabilities of such devices. We construct a mode diagram of RBC behavior (e.g. displacement, zig-zagging, and intermediate modes) and identify several regimes of RBC dynamics (e.g. tumbling, tank-treading, and trilobe motion). Furthermore, we link the complex interaction dynamics of RBCs with the post to their effective cell size and discuss relevant physical mechanisms governing the dynamic cell states. In conclusion, sorting of RBCs in DLD devices based on their shear elasticity is in general possible, but requires fine-tuning of flow conditions to targeted mechanical properties of the RBCs.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
