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双重广义线性模型揭示高智力者在大脑皮层厚度上更相似

Double Generalized Linear Model Reveals Those with High Intelligence are More Similar in Cortical Thickness

Qi Zhao, Lingli Zhang, Chun Shen, Jie Zhang, Jianfeng Feng

摘要:

大多数研究表明,智力(g)与皮质厚度呈正相关。然而,皮质厚度的个体间变异性没有被考虑在内。在这项研究中,我们的目的是确定青少年的智力和皮质厚度之间的关联,从组的平均值和分散的角度来看,利用结构脑成像从青少年大脑和认知发展(ABCD)联盟,最大的队列在10岁左右的早期青少年。采用双广义线性模型(DGLM)估计皮质厚度的均值和离散度参数及其与智力的关系。我们发现,对于平均模型部分,额叶的厚度,如额上回是负相关的智力,而表面积是最积极的额叶智力。在离散部分,智力与广泛区域的皮质厚度离散度呈负相关,而与表面积无关。这些结果表明,高智商的人在皮质厚度上更相似,这可能与皮质柱的分化或异质性较少有关。

英文摘要:

Most studies indicate that intelligence (g) is positively correlated with cortical thickness. However, the interindividual variability of cortical thickness has not been taken into account. In this study, we aimed to identify the association between intelligence and cortical thickness in adolescents from both the group's mean and dispersion point of view, utilizing the structural brain imaging from the Adolescent Brain and Cognitive Development (ABCD) Consortium, the largest cohort in early adolescents around 10 years old. The mean and dispersion parameters of cortical thickness and their association with intelligence were estimated using double generalized linear models(DGLM). We found that for the mean model part, the thickness of the frontal lobe like superior frontal gyrus was negatively related to intelligence, while the surface area was most positively associated with intelligence in the frontal lobe. In the dispersion part, intelligence was negatively correlated with the dispersion of cortical thickness in widespread areas, but not with the surface area. These results suggested that people with higher IQ are more similar in cortical thickness, which may be related to less differentiation or heterogeneity in cortical columns.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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