#neverforget -光生物调节治疗阿尔茨海默病：系统评价
#neverforget - Photobiomodulation Against Alzheimer's Disease: A Systematic Review
摘要：
老年痴呆症影响着越来越多的老年人。目前的治疗选择仅限于轻度至中度痴呆阶段的狭窄时间范围，患者面临着疾病不可避免的进展。大多数研究药物未能在临床试验中证明其疗效，并且只有少数预防措施可以采取。一种新的治疗方法，使用光生物调节来增加大脑的线粒体功能和防止神经元凋亡，在体外和体内实验中显示出有希望的结果。本系统综述旨在对光生物调节治疗阿尔茨海默病的现有研究进行全面总结，以支持这种模式从实验室到床边的翻译。它表明，在细胞水平上已经基本了解了机制作用，在动物模型中发现了安全有效的剂量，并且第一个人类案例研究为进入大规模临床试验提供了理由。对研究设计的简要展望总结了这篇综述，并为该主题的进一步工作提供了基础。
英文摘要：
Alzheimer's disease affects an ever-increasing number of people in the aging population. Current treatment options are limited to a narrow time frame at the mild to moderate stage of dementia, and patients are confronted with the inevitable progression of their disease. Most investigational drugs fail to prove their efficacy in clinical trials, and there are but a few preventative measures that one can take. A novel treatment approach, using photobiomodulation to increase the brain's mitochondrial function and prevent neuronal apoptosis, has shown promising results in in vitro and in vivo experiments. This systematic review aims at providing a comprehensive summary on the available research on photobiomodulation against Alzheimer's disease to support the translation of this modality from bench to bedside. It shows that the mechanistic action has been largely understood on a cellular level, safe and effective doses have been found in animal models, and first human case studies provide reason to enter large scale clinical trials. A brief outlook on study design concludes this review and provides a basis for further work on the topic.
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