巨噬细胞、破骨细胞和巨多核细胞中细胞-细胞融合的群体稳定性风险和生物物理学益处
Population stability risks and biophysical benefits of cell-cell fusion in macrophage, osteoclast, and giant multinucleated cells
摘要：
植物和动物细胞通常被理解为通过分化和不对称分裂获得专门功能。然而，当两个或多个细胞融合在一起，混合细胞质和遗传物质时，也会获得独特的能力。在这里，我们将成像实验与生物物理建模相结合，以进行细胞-细胞融合的第一次风险-效益分析。一方面，我们发现融合引入了一个内在的不稳定性的人口动态。另一方面，我们测量了一个不寻常的生理尺度，表明这些细胞以较低的能量成本长得更大。细胞骨架的进一步分析发现，自组织多核细胞表型的F-肌动蛋白的大小相关的相分离。
英文摘要：
Plant and animal cells are commonly understood as acquiring specialized functions through differentiation and asymmetric division. However, unique capabilities are also acquired when two or more cells fuse together, mixing cytoplasmic and genetic material. Here, we combine imaging experiments with biophysical modeling to perform the first risk-benefit analysis of cell-cell fusion. On one hand, we find fusion introduces an intrinsic instability to the population dynamics. On the other hand, we measure an unusual physiological scaling suggesting these cells grow substantially larger at lower energetic costs. Further analysis of the cytoskeleton finds a size-associated phase separation of F-actin that self-organizes multinucleated cell phenotypes.
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