自发癌芽的自组织非平衡动力学
The self-organised, non-equilibrium dynamics of spontaneous cancerous buds
摘要：
组织自组织成定义和良好控制的三维结构是至关重要的发育过程中产生的器官。在癌症的异常生长过程中，也可能发生类似但高度紊乱的过程，通常表现为原始组织的有序结构的丧失，但保留了球体、股和芽形式的多细胞组织。当肿瘤块切换到对周围组织的侵入行为时，经常可以看到后一种结构。然而，控制肿瘤细胞群自组织结构的一般物理原理仍然不清楚。在这项工作中，我们进行体外实验，以表征胶质母细胞瘤萌芽出现的单层的生长特性。使用理论模型和数值工具，在这里，我们发现，这样的拓扑结构的转变是一个自组织的，非平衡的现象驱动的贸易-关闭的机械力和物理相互作用施加在细胞-细胞和细胞-基质粘附。值得注意的是，不受控制的细胞增殖的不稳定的无序状态在宏观上表现为复杂的时空模式，其通过普遍规律在统计学上相关地演变。
英文摘要：
Tissue self-organization into defined and well-controlled three-dimensional structures is essential during development for the generation of organs. A similar, but highly deranged process might also occur during the aberrant growth of cancers, which frequently display a loss of the orderly structures of the tissue of origin, but retain a multicellular organization in the form of spheroids, strands, and buds. The latter structures are often seen when tumors masses switch to an invasive behavior into surrounding tissues. However, the general physical principles governing the self-organized architectures of tumor cell populations remain by and large unclear. In this work, we perform in-vitro experiments to characterize the growth properties of glioblastoma budding emerging from monolayers. Using a theoretical model and numerical tools here we find that such a topological transition is a self-organised, non-equilibrium phenomenon driven by the trade--off of mechanical forces and physical interactions exerted at cell-cell and cell-substrate adhesions. Notably, the unstable disorder states of uncontrolled cellular proliferation macroscopically emerge as complex spatio--temporal patterns that evolve statistically correlated by a universal law.
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