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arXiv 1905.01243stat.MEstat.AP
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对数正态数据的Meta分析中估计研究间方差和总体效应的模拟研究

Simulation study of estimating between-study variance and overall effect in meta-analyses of log-response-ratio for lognormal data

Ilyas Bakbergenuly, David C. Hoaglin, Elena Kulinskaya

摘要:

随机效应荟萃分析方法需要估计研究间方差$τ^2$。$τ^2$估计量的性能(通过偏倚和覆盖率测量)影响其在评估研究水平效应异质性方面的有用性,也影响总体效应相关估计量的性能。对于效应度量对数响应比(LRR,也称为均值比的对数,RoM),我们回顾了$τ^2$的四个点估计(流行的方法DerSimonian-Laird(DL)、限制极大似然、Mandel和Paule(MP)以及不太熟悉的Jackson方法),$τ^2$的四种区间估计(剖面似然、Q剖面、Biggerstaff和Jackson以及Jackson),总体效应的五点估计量(四个与$τ^2$的点估计量和权重仅使用研究水平样本量的估计量相关),和7个总体效应的区间估计量(4个基于$τ^2$的点估计量、Hartung-Knapp-Sidik-Jonkman(HKSJ)区间、使用$τ^2$的MP估计量而非DL估计量的HKSJ修改版以及基于样本量加权估计量的区间)。我们从对数正态分布的数据的广泛模拟获得经验证据。

英文摘要:

Methods for random-effects meta-analysis require an estimate of the between-study variance, $τ^2$. The performance of estimators of $τ^2$ (measured by bias and coverage) affects their usefulness in assessing heterogeneity of study-level effects, and also the performance of related estimators of the overall effect. For the effect measure log-response-ratio (LRR, also known as the logarithm of the ratio of means, RoM), we review four point estimators of $τ^2$ (the popular methods of DerSimonian-Laird (DL), restricted maximum likelihood, and Mandel and Paule (MP), and the less-familiar method of Jackson), four interval estimators for $τ^2$ (profile likelihood, Q-profile, Biggerstaff and Jackson, and Jackson), five point estimators of the overall effect (the four related to the point estimators of $τ^2$ and an estimator whose weights use only study-level sample sizes), and seven interval estimators for the overall effect (four based on the point estimators for $τ^2$, the Hartung-Knapp-Sidik-Jonkman (HKSJ) interval, a modification of HKSJ that uses the MP estimator of $τ^2$ instead of the DL estimator, and an interval based on the sample-size-weighted estimator). We obtain empirical evidence from extensive simulations of data from lognormal distributions.

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