1.5T和3 T下采用径向自由运行快速中断稳态（FISS）序列的天然脂肪抑制5D全心脏MRI
Natively Fat-Suppressed 5D Whole-Heart MRI with a Radial Free-Running Fast-Interrupted Steady-State (FISS) Sequence at 1.5T and 3T
摘要：
目的：在1.5T和3 T条件下，针对本机脂肪抑制自由运行5D全心MRI实施、优化和测试快速中断稳态（FISS）。方法：在1.5T和3 T条件下，采用FISS进行完全自门控自由运行心脏和心脏运动分辨径向成像。进行数值模拟和体模扫描以比较脂肪抑制特性并确定有效脂肪抑制的参数范围（每个FISS模块的读数（NR）和重复时间（TR））。随后，在10名健康志愿者中收集自由运行的FISS数据。将所有采集与相同序列的连续bSSFP版本进行比较，并分析脂肪抑制和扫描时间。结果：模拟结果表明，在FISS中的抑制带的宽度和位置是依赖于TR和NR。对于100 Hz的脂肪抑制带宽和低于8的NR，模拟表明，在1.5 T下需要2.2 ms至3.0 ms的TR，而在3 T下适用3.0 ms至3.5 ms的范围。脂肪信号随NR增加。这些发现在幻影实验中得到了证实。在志愿者中，在两种场强下使用FISS与bSSPF相比，脂肪SNR显著降低。经过协议优化，高分辨率（1.1mm x 1.1mm x 1.1mm）5D全心脏自由运行FISS可以在1.5T和3 T下在8分钟内进行有效的脂肪抑制，与bSSFP相比，扫描时间适度增加。确定了最佳FISS参数范围，实现天然脂肪抑制的5D全心自由-在1.5T和3 T下运行MRI，进行单次连续扫描，证明了心脏成像和非造影血管造影的潜力。
英文摘要：
Purpose: To implement, optimize and test fast interrupted steady-state (FISS) for natively fat-suppressed free-running 5D whole-heart MRI at 1.5T and 3T. Methods: FISS was implemented for fully self-gated free-running cardiac- and respiratory-motion-resolved radial imaging of the heart at 1.5T and 3T. Numerical simulations and phantom scans were performed to compare fat suppression characteristics and to determine parameter ranges (readouts per FISS module (NR) and repetition time (TR)) for effective fat suppression. Subsequently, free-running FISS data were collected in ten healthy volunteers. All acquisitions were compared with a continuous bSSFP version of the same sequence, and both fat suppression and scan times were analyzed. Results: Simulations demonstrate a variable width and location of suppression bands in FISS that was dependent on TR and NR. For a fat suppression bandwidth of 100Hz and NR below 8, simulations demonstrated that a TR between 2.2ms and 3.0ms is required at 1.5T while a range of 3.0ms to 3.5ms applies at 3T. Fat signal increases with NR. These findings were corroborated in phantom experiments. In volunteers, fat SNR was significantly decreased using FISS compared with bSSPF at both field strengths. After protocol optimization, high-resolution (1.1mm x 1.1mm x 1.1mm) 5D whole-heart free-running FISS can be performed with effective fat suppression in under 8 min at 1.5T and 3T at a modest scan time increase compared to bSSFP.Conclusion: An optimal FISS parameter range was determined enabling natively fat-suppressed 5D whole-heart free-running MRI with a single continuous scan at 1.5T and 3T, demonstrating potential for cardiac imaging and noncontrast angiography.
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