单个发动机的有限加工能力提高了自组装发动机-货物复合体的整体运输通量
Limited processivity of single motors improves overall transport flux of self-assembled motor-cargo complexes
摘要：
单个驱动蛋白分子马达在解离前可以沿着微管（MT）进行平均几微米的连续运动。然而，发生运输的细胞长度尺度是几百微米或更大。为什么看似不可靠的发动机被用来运输细胞货物仍然知之甚少。我们提出了一个新的理论，如何低的持续性，一个单一回合的定向运动的平均长度，可以提高细胞运输时，电机和货物必须首先扩散自组装成复合物。我们采用随机建模，以确定对整体货物运输流量的持续性的影响。我们表明，在广泛的生理相关条件下，拥有“无限”的持续合成能力并不能最大限度地提高沿MT的通量。相反，我们发现低的持续合成能力，马达与MT的弱结合是最佳的。这些结果揭示了持续合成能力和运输效率之间的关系，并为低运动持续合成能力的生理益处提供了新的理论。
英文摘要：
Single kinesin molecular motors can processively move along a microtubule (MT) a few micrometers on average before dissociating. However, cellular length scales over which transport occurs are several hundred microns and more. Why seemingly unreliable motors are used to transport cellular cargo remains poorly understood. We propose a new theory for how low processivity, the average length of a single bout of directed motion, can enhance cellular transport when motors and cargoes must first diffusively self assemble into complexes. We employ stochastic modeling to determine the effect of processivity on overall cargo transport flux. We show that, under a wide range of physiologically relevant conditions, possessing "infinite" processivity does not maximize flux along MTs. Rather, we find that low processivity i.e., weak binding of motors to MTs, is optimal. These results shed light on the relationship between processivity and transport efficiency and offer a new theory for the physiological benefits of low motor processivity.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
