细胞集落：早期进化细胞分选的模型及其在黏菌D中的应用。discoideum
Cell pelotons: a model of early evolutionary cell sorting, with application to slime mold D. discoideum
摘要：
一个理论模型，提出了早期进化细胞内细胞聚集体分选。该模型涉及一个节能机制和集体自组织的原则，类似于自行车pelotons（骑自行车的群体）中观察到的。的理论框架被应用到泥模蛞蝓（Dictyosteelium discoideum），并纳入计算机模拟，主要表现在前，后蛞蝓区域之间的细胞的排序。该模拟依赖于现有的自行车珀洛东动力学的模拟，该模拟被修改为在异质细胞之间结合有限范围的细胞代谢能力，以及可调的能量消耗参数，被称为“输出水平”或“饥饿水平”以反映能量供应减少，原细胞动力学被建模为三个输出阶段：“活跃”，“受苦”和“垂死或死亡”。调节饥饿参数导致细胞分化并在细胞聚集体内分选成亚组。饥饿参数的调整展示了弱细胞或过期细胞如何在细胞聚集体内向后洗牌。
英文摘要：
A theoretical model is presented for early evolutionary cell sorting within cellular aggregates. The model involves an energy-saving mechanism and principles of collective self-organization analogous to those observed in bicycle pelotons (groups of cyclists). The theoretical framework is applied to slime-mold slugs (Dictyostelium discoideum) and incorporated into a computer simulation which demonstrates principally the sorting of cells between the anterior and posterior slug regions. The simulation relies on an existing simulation of bicycle peloton dynamics which is modified to incorporate a limited range of cell metabolic capacities among heterogeneous cells, along with a tunable energy-expenditure parameter, referred to as an 'output-level' or 'starvation-level' to reflect diminishing energetic supply, proto-cellular dynamics are modelled for three output phases: 'active', 'suffering', and 'dying or dead.' Adjusting the starvation parameter causes cell differentiation and sorting into sub-groups within the cellular aggregate. Tuning of the starvation parameter demonstrates how weak or expired cells shuffle backward within the cellular aggregate.
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