声散射介导的单探测器光声断层成像
Acoustic scattering mediated single detector optoacoustic tomography
摘要：
光声图像形成通常基于来自多个检测位置的超声飞行时间读数。在这里，我们利用声散射物理编码的位置，光学吸收器在采集的信号，从而减少所需的数据量，从一个单一的波形重建图像。通过在样品和超声检测器阵列之间包括散射体的随机分布来实验地测试该概念。通过随机散射介质的超声波传输通过光栅扫描横跨笛卡尔网格的光吸收微粒来校准。然后，利用依赖于校准信号的正则化的基于模型的迭代算法，实现来自单个时间分辨信号的图像重建。捕获整个散射波场所需的相对短的采集时间窗口有助于信号压缩效率。所证明的使用单个记录的光声波形形成图像的可行性为开发更快且负担得起的光声成像系统铺平了道路。
英文摘要：
Optoacoustic image formation is conventionally based upon ultrasound time-of-flight readings from multiple detection positions. Herein, we exploit acoustic scattering to physically encode the position of optical absorbers in the acquired signals, thus reduce the amount of data required to reconstruct an image from a single waveform. This concept is experimentally tested by including a random distribution of scatterers between the sample and an ultrasound detector array. Ultrasound transmission through a randomized scattering medium was calibrated by raster scanning a light-absorbing microparticle across a Cartesian grid. Image reconstruction from a single time-resolved signal was then enabled with a regularized model-based iterative algorithm relying on the calibration signals. The signal compression efficiency is facilitated by the relatively short acquisition time window needed to capture the entire scattered wavefield. The demonstrated feasibility to form an image using a single recorded optoacoustic waveform paves a way to the development of faster and affordable optoacoustic imaging systems.
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