单纳米粒子水平的非线性纳米力学质谱
Nonlinear Nanomechanical Mass Spectrometry at the Single-Nanoparticle Level
摘要：
纳米机电系统（NEMS）已经成为一种有前途的技术，用于执行大生物分子和纳米颗粒的质谱分析。当纳米级物体一个接一个地落在NEMS传感器上时，它们会导致传感器的谐振频率发生与它们的重量成比例的可分辨的偏移。NEMS传感器的操作机制通常受到非线性起始的限制，超过非线性起始，基于锁相环频率跟踪的高灵敏度方案不能容易地使用。在这里，我们开发了一种测量架构，在非线性制度和测量频率变化引起的分析物在一个快速和灵敏的方式。我们使用这种架构来单独表征金纳米颗粒的质量，并通过基于线性质量传感对相同的纳米颗粒进行独立测量来验证结果。一旦建立了该技术的可行性，我们已经获得了一个20 nm的金纳米粒子样品的质谱，通过单独记录约500个单粒子事件，使用两种模式在非线性制度顺序工作。这里获得的技术可用于薄的纳米机械结构，具有有限的动态范围。
英文摘要：
Nanoelectromechanical Systems (NEMS) have emerged as a promising technology for performing the mass spectrometry of large biomolecules and nanoparticles. As nanoscale objects land on NEMS sensor one by one, they induce resolvable shifts in the resonance frequency of the sensor proportional to their weight. The operational regime of NEMS sensors is often limited by the onset-of-nonlinearity, beyond which the highly sensitive schemes based on frequency tracking by phase-locked loops cannot be readily used. Here, we develop a measurement architecture to operate at the nonlinear regime and measure frequency shifts induced by analytes in a rapid and sensitive manner. We used this architecture to individually characterize the mass of gold nanoparticles and verified the results by performing independent measurements of the same nanoparticles based on linear mass sensing. Once the feasibility of the technique is established, we have obtained the mass spectrum of a 20 nm gold nanoparticle sample by individually recording about five hundred single particle events using two modes working sequentially in the nonlinear regime. The technique obtained here can be used for thin nanomechanical structures which possess a limited dynamic range.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
