Class-Aware Adversarial Lung Nodule Synthesis in CT Images
Siemens Healthineers（西门子医疗）
Jie Yang, Siqi Liu, Sasa Grbic, Arnaud Arindra Adiyoso Setio, Zhoubing Xu, Eli Gibson, Guillaume Chabin, Bogdan Georgescu, Andrew F. Laine, Dorin Comaniciu
Though large-scale datasets are essential for training deep learning systems, it is expensive to scale up the collection of medical imaging datasets. Synthesizing the objects of interests, such as lung nodules, in medical images based on the distribution of annotated datasets can be helpful for improving the supervised learning tasks, especially when the datasets are limited by size and class balance. In this paper, we propose the class-aware adversarial synthesis framework to synthesize lung nodules in CT images. The framework is built with a coarse-to-fine patch in-painter (generator) and two class-aware discriminators. By conditioning on the random latent variables and the target nodule labels, the trained networks are able to generate diverse nodules given the same context. By evaluating on the public LIDC-IDRI dataset, we demonstrate an example application of the proposed framework for improving the accuracy of the lung nodule malignancy estimation as a binary classification problem, which is important in the lung screening scenario. We show that combining the real image patches and the synthetic lung nodules in the training set can improve the mean AUC classification score across different network architectures by 2%.
Lung nodules can be an alarming precursor to potential lung cancer. Missed nodule detections during chest radiograph analysis remains a common challenge among thoracic radiologists. In this work, we present a multi-task lung nodule detection algorithm for chest radiograph analysis. Unlike past approaches, our algorithm predicts a global-level label indicating nodule presence along with local-level labels predicting nodule locations using a Dual Head Network (DHN). We demonstrate the favorable nodule detection performance that our multi-task formulation yields in comparison to conventional meth…
Lung nodules suffer large variation in size and appearance in CT images. Nodules less than 10mm can easily lose information after down-sampling in convolutional neural networks, which results in low sensitivity. In this paper, a combination of 3D image and feature pyramid is exploited to integrate lower-level texture features with high-level semantic features, thus leading to a higher recall. However, 3D operations are time and memory consuming, which aggravates the situation with the explosive growth of medical images. To tackle this problem, we propose a general curriculum training strategy …
Rensselaer Polytechnic Institute（伦斯勒理工学院）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）
Although radiographs are the most frequently used worldwide due to their cost-effectiveness and widespread accessibility, the structural superposition along the x-ray paths often renders suspicious or concerning lung nodules difficult to detect. In this study, we apply "X-ray dissectography" to dissect lungs digitally from a few radiographic projections, suppress the interference of irrelevant structures, and improve lung nodule detectability. For this purpose, a collaborative detection network is designed to localize lung nodules in 2D dissected projections and 3D physical space. Our experime…
Jordan University of Science and Technology（约旦科技大学）
Purpose: The lung nodules localization in CT scan images is the most difficult task due to the complexity of the arbitrariness of shape, size, and texture of lung nodules. This is a challenge to be faced when coming to developing different solutions to improve detection systems. the deep learning approach showed promising results by using convolutional neural network (CNN), especially for image recognition and it's one of the most used algorithm in computer vision. Approach: we use (CNN) building blocks based on YOLOv5 (you only look once) to learn the features representations for nodule detec…
The Ohio State University（俄亥俄州立大学）；University of Massachusetts Lowell（马萨诸塞大学洛厄尔分校）；Rensselaer Polytechnic Institute（伦斯勒理工学院）
Deep learning, as a promising new area of machine learning, has attracted a rapidly increasing attention in the field of medical imaging. Compared to the conventional machine learning methods, deep learning requires no hand-tuned feature extractor, and has shown a superior performance in many visual object recognition applications. In this study, we develop a deep convolutional neural network (CNN) and apply it to thoracic CT images for the classification of lung nodules. We present the CNN architecture and classification accuracy for the original images of lung nodules. In order to understand…
Arkansas State University（阿肯色州立大学）；University of Minnesota（明尼苏达大学）；The Chinese University of Hong Kong（香港中文大学）；Shanghai University of Finance and Economics（上海财经大学）；Washington University（华盛顿大学）；University of Arkansas for Medical Sciences（阿肯色大学医学科学校区）
Computed tomography (CT) examinations are commonly used to predict lung nodule malignancy in patients, which are shown to improve noninvasive early diagnosis of lung cancer. It remains challenging for computational approaches to achieve performance comparable to experienced radiologists. Here we present NoduleX, a systematic approach to predict lung nodule malignancy from CT data, based on deep learning convolutional neural networks (CNN). For training and validation, we analyze >1000 lung nodules in images from the LIDC/IDRI cohort. All nodules were identified and classified by four experienc…
Candidate generation, the first stage for most computer aided detection (CAD) systems, rapidly scans the entire image data for any possible abnormality locations, while the subsequent stages of the CAD system refine the candidates list to determine the most probable or significant of these candidates. The candidate generator creates a list of the locations and provides a size estimate for each candidate. A multiscale scale-normalized Laplacian of Gaussian (LoG) filtering method for detecting pulmonary nodules in whole-lung CT scans, presented in this paper, achieves a high sensitivity for both…
In this work we present a method for lung nodules segmentation, their texture classification and subsequent follow-up recommendation from the CT image of lung. Our method consists of neural network model based on popular U-Net architecture family but modified for the joint nodule segmentation and its texture classification tasks and an ensemble-based model for the follow-up recommendation. This solution was evaluated within the LNDb medical imaging challenge and produced the best nodule segmentation result on the final leaderboard.
MESAHA-Net: Multi-Encoders based Self-Adaptive Hard Attention Network with Maximum Intensity Projections for Lung Nodule Segmentation in CT Scan
Department of Computer Science and Engineering, Seoul National University（计算机科学与工程系，首尔国立大学）；Center for Artificial Intelligence in Medicine and Imaging, HealthHub Co. Ltd.（医学与影像人工智能中心，HealthHub公司）；Department of Electrical and Computer Engineering, The University of Alabama（电气与计算机工程系，阿拉巴马大学）；Department of Electrical Engineering, COMSATS University Islamabad（电气工程系，COMSATS大学伊斯兰堡分校）
Harbin Institute of Technology（哈尔滨工业大学）；CVTE Research（视源股份研究院）；Southern University of Science and Technology（南方科技大学）；Guangdong University of Technology（广东工业大学）；CVTE（视源股份）
In the management of lung nodules, we are desirable to predict nodule evolution in terms of its diameter variation on Computed Tomography (CT) scans and then provide a follow-up recommendation according to the predicted result of the growing trend of the nodule. In order to improve the performance of growth trend prediction for lung nodules, it is vital to compare the changes of the same nodule in consecutive CT scans. Motivated by this, we screened out 4,666 subjects with more than two consecutive CT scans from the National Lung Screening Trial (NLST) dataset to organize a temporal dataset ca…
NoduLoCC2026: Lung Nodule Localization and Classification Contest from Chest X-Ray Images
Université de Haute-Alsace, IRIMAS（上阿尔萨斯大学，IRIMAS实验室）；IMT Nord Europe, Institut Mines-Télécom, Université de Lille, Center for Digital Systems（IMT北欧洲，矿业电信学院，里尔大学，数字系统中心）；Université de Rouen Normandie, ESIGELEC, IRSEEM（鲁昂诺曼底大学，ESIGELEC工程师学院，IRSEEM研究所）；Universidade Estadual de Campinas（坎皮纳斯州立大学）；Université du Québec à Chicoutimi（魁北克大学希库蒂米分校）；Università Politecnica delle Marche（马尔凯理工大学）；Université de Bejaia, Faculté des Sciences Exactes, Laboratoire d’Informatique Médicale et des Environnements Dynamiques et Intelligents (LIMED)（贝贾亚大学，精密科学学院，医学信息与动态智能环境实验室）；Université de Bretagne Occidentale（西布列塔尼大学）；University of Derby（德比大学）
School of Biomedical Engineering and Imaging Sciences, King’s College London（伦敦国王学院生物医学工程与影像科学学院）；BioMedIA, Department of Computing, Imperial College London（帝国理工学院计算系生物医学影像与数据分析中心）；Department of Radiology, University College London（伦敦大学学院放射学系）；The Royal Brompton & Harefield NHS Foundation Trust（皇家布朗普顿和哈菲尔德英国国民保健信托基金会）；Technical University of Munich（慕尼黑工业大学）；Helmholtz Center Munich（亥姆霍兹慕尼黑中心）
Convolutional Neural Networks (CNNs) are widely used for image classification in a variety of fields, including medical imaging. While most studies deploy cross-entropy as the loss function in such tasks, a growing number of approaches have turned to a family of contrastive learning-based losses. Even though performance metrics such as accuracy, sensitivity and specificity are regularly used for the evaluation of CNN classifiers, the features that these classifiers actually learn are rarely identified and their effect on the classification performance on out-of-distribution test samples is ins…
University of Groningen, University Medical Center Groningen（格罗宁根大学医学中心）；Tianjin Medical University Cancer Institute and Hospital（天津医科大学肿瘤医院）；University of Twente（特温特大学）
Accurate pulmonary nodule detection is a crucial step in lung cancer screening. Computer-aided detection (CAD) systems are not routinely used by radiologists for pulmonary nodule detection in clinical practice despite their potential benefits. Maximum intensity projection (MIP) images improve the detection of pulmonary nodules in radiological evaluation with computed tomography (CT) scans. Inspired by the clinical methodology of radiologists, we aim to explore the feasibility of applying MIP images to improve the effectiveness of automatic lung nodule detection using convolutional neural netwo…
Objectives: To compare artificial intelligence (AI) as a second reader in detecting lung nodules on chest X-rays (CXR) versus radiologists of two binational institutions, and to evaluate AI performance when using two different modes: automated versus assisted (additional remote radiologist review). Methods: The CXR public database (n = 247) of the Japanese Society of Radiological Technology with various types and sizes of lung nodules was analyzed. Eight radiologists evaluated the CXR images with regard to the presence of lung nodules and nodule conspicuity. After radiologist review, the AI so…
A Lung Nodule Dataset with Histopathology-based Cancer Type Annotation
School of Computer Science and Technology, Shandong University of Finance and Economics（山东财经大学计算机科学与技术学院）；School of Information Science and Technology, Linyi University（临沂大学信息科学与技术学院）；Thoracic Surgery Department of Linyi Central Hospital（临沂市中心医院胸外科）；Personnel Department of Linyi Central Hospital（临沂市中心医院人事科）
King’s College London（伦敦国王学院）；Guy’s & St Thomas’ NHS Foundation Trust（盖伊和圣托马斯国民保健服务基金会信托）；Imperial College Healthcare NHS Trust（帝国理工学院医疗国民保健服务信托）
Machine learning approaches hold great potential for the automated detection of lung nodules in chest radiographs, but training the algorithms requires vary large amounts of manually annotated images, which are difficult to obtain. Weak labels indicating whether a radiograph is likely to contain pulmonary nodules are typically easier to obtain at scale by parsing historical free-text radiological reports associated to the radiographs. Using a repositotory of over 700,000 chest radiographs, in this study we demonstrate that promising nodule detection performance can be achieved using weak label…
Indian Institute of Technology Kharagpur（印度理工学院卡拉格普尔分校）；Intel Technology India Pvt. Ltd.（英特尔技术印度私人有限公司）
Lung cancer is the most common form of cancer found worldwide with a high mortality rate. Early detection of pulmonary nodules by screening with a low-dose computed tomography (CT) scan is crucial for its effective clinical management. Nodules which are symptomatic of malignancy occupy about 0.0125 - 0.025\% of volume in a CT scan of a patient. Manual screening of all slices is a tedious task and presents a high risk of human errors. To tackle this problem we propose a computationally efficient two stage framework. In the first stage, a convolutional neural network (CNN) trained adversarially …
University of Copenhagen（哥本哈根大学）；Rigshospitalet, Copenhagen University Hospital（哥本哈根大学医院 Rigshospitalet）；Hong Kong Baptist University（香港浸会大学）
Feature-based self-explanatory methods explain their classification in terms of human-understandable features. In the medical imaging community, this semantic matching of clinical knowledge adds significantly to the trustworthiness of the AI. However, the cost of additional annotation of features remains a pressing issue. We address this problem by proposing cRedAnno, a data-/annotation-efficient self-explanatory approach for lung nodule diagnosis. cRedAnno considerably reduces the annotation need by introducing self-supervised contrastive learning to alleviate the burden of learning most para…
Institute for Systems and Computer Engineering, Technology and Science (INESC TEC)（系统与计算机工程、技术与科学研究所（INESC TEC））；Faculty of Engineering of the University of Porto (FEUP)（波尔图大学工程学院（FEUP））；University of Trás-os-Montes e Alto Douro (UTAD)（山后-上杜罗大学（UTAD））；Centro Hospitalar e Universitário de S. João（圣若昂大学医院中心）；Faculty of Medicine of the University of Porto (FMUP)（波尔图大学医学院（FMUP））
Lung cancer is the deadliest type of cancer worldwide and late detection is the major factor for the low survival rate of patients. Low dose computed tomography has been suggested as a potential screening tool but manual screening is costly, time-consuming and prone to variability. This has fueled the development of automatic methods for the detection, segmentation and characterisation of pulmonary nodules but its application to clinical routine is challenging. In this study, a new database for the development and testing of pulmonary nodule computer-aided strategies is presented which intends…
Monash University Malaysia（莫纳什大学马来西亚分校）；Agency for Science, Technology and Research (A*STAR)（新加坡科技研究局）；CNRS（法国国家科学研究中心）；Singapore Eye Research Institute（新加坡眼科研究所）；University of Oklahoma（俄克拉荷马大学）
Different types of Convolutional Neural Networks (CNNs) have been applied to detect cancerous lung nodules from computed tomography (CT) scans. However, the size of a nodule is very diverse and can range anywhere between 3 and 30 millimeters. The high variation of nodule sizes makes classifying them a difficult and challenging task. In this study, we propose a novel CNN architecture called Gated-Dilated (GD) networks to classify nodules as malignant or benign. Unlike previous studies, the GD network uses multiple dilated convolutions instead of max-poolings to capture the scale variations. Mor…
PURPOSE: This study aimed to develop a deep learning-based tool to detect and localize lung nodules with chest radiographs(CXRs). We expected it to enhance the efficiency of interpreting CXRs and reduce the possibilities of delayed diagnosis of lung cancer. MATERIALS AND METHODS: We collected CXRs from NCKUH database and VBD, an open-source medical image dataset, as our training and validation data. A number of CXRs from the Ministry of Health and Welfare(MOHW) database served as our test data. We built a segmentation model to identify lung areas from CXRs, and sliced them into 16 patches. Phy…
Lung nodule classification on CT scan patches using 3D convolutional neural networks
Institute for Applied System Analysis of National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”（乌克兰国立技术大学“伊戈尔·西科尔斯基基辅理工学院”应用系统分析研究所）
Mohamed bin Zayed University of Artificial Intelligence（穆罕默德·本·扎耶德人工智能大学）
Lung cancer is a leading cause of death worldwide. Early-stage detection of lung cancer is essential for a more favorable prognosis. Radiogenomics is an emerging discipline that combines medical imaging and genomics features for modeling patient outcomes non-invasively. This study presents a radiogenomics pipeline that has: 1) a novel mixed architecture (RA-Seg) to segment lung cancer through attention and recurrent blocks; and 2) deep feature classifiers to distinguish Epidermal Growth Factor Receptor (EGFR) mutation status. We evaluate the proposed algorithm on multiple public datasets to as…
Full-resolution Lung Nodule Segmentation from Chest X-ray Images using Residual Encoder-Decoder Networks
University of Technology Sydney（悉尼科技大学）；IBM Australia Limited（IBM澳大利亚有限公司）；University of New England（新英格兰大学）；Universiti Kebangsaan Malaysia（马来西亚国民大学）；Charles Sturt University（查尔斯斯特大学）；Westmead Hospital（韦斯特米德医院）；Cogninet Australia（科尼尼特澳大利亚公司）；University of Southern Queensland（南昆士兰大学）；Data Science Institute, University of Technology Sydney（悉尼科技大学数据科学学院）
College of Physics and Information Engineering, Fuzhou University（福州大学物理与信息工程学院）；Thoracic Department, Fujian Medical University Union Hospital（福建医科大学附属协和医院胸外科）
Background and Objective:Computer-aided diagnosis (CAD) systems promote diagnosis effectiveness and alleviate pressure of radiologists. A CAD system for lung cancer diagnosis includes nodule candidate detection and nodule malignancy evaluation. Recently, deep learning-based pulmonary nodule detection has reached satisfactory performance ready for clinical application. However, deep learning-based nodule malignancy evaluation depends on heuristic inference from low-dose computed tomography volume to malignant probability, which lacks clinical cognition. Methods:In this paper, we propose a joint…
LMLCC-Net: A Semi-Supervised Deep Learning Model for Lung Nodule Malignancy Prediction from CT Scans using a Novel Hounsfield Unit-Based Intensity Filtering
mHealth Lab, Department of Biomedical Engineering, Bangladesh University of Engineering and Technology（孟加拉国工程与技术大学生物医学工程系mHealth实验室）
We introduce a new computer aided detection and diagnosis system for lung cancer screening with low-dose CT scans that produces meaningful probability assessments. Our system is based entirely on 3D convolutional neural networks and achieves state-of-the-art performance for both lung nodule detection and malignancy classification tasks on the publicly available LUNA16 and Kaggle Data Science Bowl challenges. While nodule detection systems are typically designed and optimized on their own, we find that it is important to consider the coupling between detection and diagnosis components. Exploiti…
Concordia University（康考迪亚大学）；Concordia Institute for Information Systems Engineering（康考迪亚信息系统工程研究所）；Sunnybrook Health Sciences Centre（桑尼布鲁克健康科学中心）；University of Toronto（多伦多大学）
Lung cancer is the leading cause of mortality from cancer worldwide and has various histologic types, among which Lung Adenocarcinoma (LUAC) has recently been the most prevalent one. The current approach to determine the invasiveness of LUACs is surgical resection, which is not a viable solution to fight lung cancer in a timely fashion. An alternative approach is to analyze chest Computed Tomography (CT) scans. The radiologists' analysis based on CT images, however, is subjective and might result in a low accuracy. In this paper, a transformer-based framework, referred to as the "CAE-Transform…
Gordon Center for Medical Imaging, Massachusetts General Hospital（麻省总医院戈登医学成像中心）；Harvard Medical School（哈佛医学院）；Beijing International Center for Mathematical Research, Peking University（北京大学北京国际数学研究中心）
Computer aided diagnostic (CAD) system is crucial for modern med-ical imaging. But almost all CAD systems operate on reconstructed images, which were optimized for radiologists. Computer vision can capture features that is subtle to human observers, so it is desirable to design a CAD system op-erating on the raw data. In this paper, we proposed a deep-neural-network-based detection system for lung nodule detection in computed tomography (CT). A primal-dual-type deep reconstruction network was applied first to convert the raw data to the image space, followed by a 3-dimensional convolutional ne…
Median Technologies（Median科技公司）；Univ. Artois（阿图瓦大学）
Pathologies systematically induce morphological changes, thus providing a major but yet insufficiently quantified source of observables for diagnosis. The study develops a predictive model of the pathological states based on morphological features (3D-morphomics) on Computed Tomography (CT) volumes. A complete workflow for mesh extraction and simplification of an organ's surface is developed, and coupled with an automatic extraction of morphological features given by the distribution of mean curvature and mesh energy. An XGBoost supervised classifier is then trained and tested on the 3D-morpho…
High-risk Factor Prediction in Lung Cancer Using Thin CT Scans: An Attention-Enhanced Graph Convolutional Network Approach
Renmin University of China（中国人民大学）；Capital Medical University（首都医科大学）；Beijing Chao-Yang Hospital（北京朝阳医院）；Beijing Institute of Respiratory Medicine（北京呼吸疾病研究所）
Eurecat Centre Tecnològic de Catalunya（加泰罗尼亚技术中心）；Universitat Pompeu Fabra（庞培法布拉大学）；Vall d'Hebron University Hospital（瓦尔德希布伦大学医院）；ICREA（加泰罗尼亚高级研究院）
We address the problem of supporting radiologists in the longitudinal management of lung cancer. Therefore, we proposed a deep learning pipeline, composed of four stages that completely automatized from the detection of nodules to the classification of cancer, through the detection of growth in the nodules. In addition, the pipeline integrated a novel approach for nodule growth detection, which relied on a recent hierarchical probabilistic U-Net adapted to report uncertainty estimates. Also, a second novel method was introduced for lung cancer nodule classification, integrating into a two stre…
Medical Artificial Intelligence for Early Detection of Lung Cancer: A Survey
College of Computer Science and Artificial Intelligence, Southwest Minzu University, Chengdu, 610225, China（计算机科学与人工智能学院，西南民族大学）；The Australian National University, Canberra ACT 2601, Australia（澳大利亚国立大学）；School of Computer Science and Technology, Beijing Jiaotong University, Beijing, China（计算机科学与技术学校，北京交通大学）；Hunan university of technology, Zhuzhou, 410072, China（湖南理工大学）；University of Adelaide, Adelaide, South Australia 5005, Australia（阿德莱德大学）；La Trobe University, Melbourne, Victoria 3086, Australia（拉筹伯大学）
University of Technology Sydney（悉尼科技大学）；IBM Australia Limited（IBM澳大利亚有限公司）；Sejong University（世宗大学）；Universiti Kebangsaan Malaysia（马来西亚国民大学）；Charles Sturt University（查尔斯特大学）
Lung cancer is the leading cause of cancer death and morbidity worldwide. Many studies have shown machine learning models to be effective at detecting lung nodules from chest X-ray images. However, these techniques have yet to be embraced by the medical community due to several practical, ethical, and regulatory constraints stemming from the black-box nature of deep learning models. Additionally, most lung nodules visible on chest X-ray are benign; therefore, the narrow task of computer vision-based lung nodule detection cannot be equated to automated lung cancer detection. Addressing both con…
Arkansas State University（阿肯色州立大学）；University of Michigan（密歇根大学）；Ann Arbor Algorithm（安阿伯算法公司）；University of Arkansas at Pine Bluff（阿肯色大学松崖分校）；University of Arkansas for Medical Sciences（阿肯色大学医学院）
Lung cancer is the leading cause of cancer deaths. Early detection through low-dose computed tomography (CT) screening has been shown to significantly reduce mortality but suffers from a high false positive rate that leads to unnecessary diagnostic procedures. Quantitative image analysis coupled to deep learning techniques has the potential to reduce this false positive rate. We conducted a computational analysis of 1449 low-dose CT studies drawn from the National Lung Screening Trial (NLST) cohort. We applied to this cohort our newly developed algorithm, DeepScreener, which is based on a nove…
University of Patras（帕特雷大学）；School of Medicine（医学院）；Laboratory of Nuclear Medicine（核医学实验室）
Lung Cancer is the most common cause of cancer-related death worldwide. Early and automatic diagnosis of Solitary Pulmonary Nodules (SPN) in Computer Tomography (CT) chest scans can provide early treatment as well as doctor liberation from time-consuming procedures. Deep Learning has been proven as a popular and influential method in many medical imaging diagnosis areas. In this study, we consider the problem of diagnostic classification between benign and malignant lung nodules in CT images derived from a PET/CT scanner. More specifically, we intend to develop experimental Convolutional Neura…
Acquisition state behaves as a structured, measurable variable governing lung-nodule AI: kernel-driven measurement instability and noise-driven detection fragility, invisible to DICOM metadata
Concordia Institute for Information Systems Engineering, Concordia University（康考迪亚大学信息系统工程研究所）；Sunnybrook Health Sciences Centre, University of Toronto（多伦多大学桑尼布鲁克健康科学中心）；McGill University Health Center- Research Institute（麦吉尔大学健康中心研究所）；Babak Imaging Center（巴布克影像中心）；Department of Electrical and Computer Engineering, University of Toronto（多伦多大学电气与计算机工程系）
Lung diseases including infections such as Pneumonia, Tuberculosis, and novel Coronavirus (COVID-19), together with Lung Cancer are significantly widespread and are, typically, considered life threatening. In particular, lung cancer is among the most common and deadliest cancers with a low 5-year survival rate. Timely diagnosis of lung cancer is, therefore, of paramount importance as it can save countless lives. In this regard, deep learning radiomics solutions have the promise of extracting the most useful features on their own in an end-to-end fashion without having access to the annotated b…
University of Applied Sciences - Wiener Neustadt（维也纳新城应用科学大学）；LAAS-CNRS（法国国家科学研究中心 LAAS 实验室）；Univ de Toulouse（图卢兹大学）
Lung cancer accounts for the highest number of cancer deaths globally. Early diagnosis of lung nodules is very important to reduce the mortality rate of patients by improving the diagnosis and treatment of lung cancer. This work proposes an automated system to classify lung nodules as malignant and benign in CT images. It presents extensive experimental results using a combination of geometric and histogram lung nodule image features and different linear and non-linear discriminant classifiers. The proposed approach is experimentally validated on the LIDC-IDRI public lung cancer screening thor…
National Institutes of Health（美国国立卫生研究院）；University of Central Florida（中佛罗里达大学）
Computed tomography imaging is a standard modality for detecting and assessing lung cancer. In order to evaluate the malignancy of lung nodules, clinical practice often involves expert qualitative ratings on several criteria describing a nodule's appearance and shape. Translating these features for computer-aided diagnostics is challenging due to their subjective nature and the difficulties in gaining a complete description. In this paper, we propose a computerized approach to quantitatively evaluate both appearance distinctions and 3D surface variations. Nodule shape was modeled and parameter…
Data availability plays a critical role for the performance of deep learning systems. This challenge is especially acute within the medical image domain, particularly when pathologies are involved, due to two factors: 1) limited number of cases, and 2) large variations in location, scale, and appearance. In this work, we investigate whether augmenting a dataset with artificially generated lung nodules can improve the robustness of the progressive holistically nested network (P-HNN) model for pathological lung segmentation of CT scans. To achieve this goal, we develop a 3D generative adversaria…
Lung nodule proposals generation is the primary step of lung nodule detection and has received much attention in recent years . In this paper, we first construct a model of 3-dimension Convolutional Neural Network (3D CNN) to generate lung nodule proposals, which can achieve the state-of-the-art performance. Then, we analyze a series of key problems concerning the training performance and efficiency. Firstly, we train the 3D CNN model with data in different resolutions and find out that models trained by high resolution input data achieve better lung nodule proposals generation performances es…
We present crowdsourcing as an additional modality to aid radiologists in the diagnosis of lung cancer from clinical chest computed tomography (CT) scans. More specifically, a complete workflow is introduced which can help maximize the sensitivity of lung nodule detection by utilizing the collective intelligence of the crowd. We combine the concept of overlapping thin-slab maximum intensity projections (TS-MIPs) and cine viewing to render short videos that can be outsourced as an annotation task to the crowd. These videos are generated by linearly interpolating overlapping TS-MIPs of CT slices…
