Memento队列中情景记忆的神经相关性
Neural correlates of episodic memory in the Memento cohort
摘要：
前言自由提示选择性回忆测验用于轻度认知障碍和痴呆患者记忆障碍的鉴别。它允许评估三个过程：编码，存储和回忆的口头episodic memory.MethodsWe调查了这三个记忆过程的神经相关性在一个大型队列研究。Memento队列招募了2323名门诊患者，他们表现为主观认知能力下降或轻度认知功能障碍，接受认知，结构MRI，并为一个子集，氟脱氧葡萄糖-正电子发射断层扫描evaluations.ResultsEncoding与网络，包括顶叶和颞叶皮质;存储主要与内嗅和海马旁区，双边;检索与一个广泛的网络，包括额叶regions.DiscussionThe神经相关的情节记忆过程中，可以评估在大型和标准化队列的患者在阿尔茨海默病的风险。它们与阿尔茨海默病的病理生理学标志物的关系仍有待研究。
英文摘要：
IntroductionThe free and cued selective reminding test is used to identify memory deficits in mild cognitive impairment and demented patients. It allows assessing three processes: encoding, storage, and recollection of verbal episodic memory.MethodsWe investigated the neural correlates of these three memory processes in a large cohort study. The Memento cohort enrolled 2323 outpatients presenting either with subjective cognitive decline or mild cognitive impairment who underwent cognitive, structural MRI and, for a subset, fluorodeoxyglucose--positron emission tomography evaluations.ResultsEncoding was associated with a network including parietal and temporal cortices; storage was mainly associated with entorhinal and parahippocampal regions, bilaterally; retrieval was associated with a widespread network encompassing frontal regions.DiscussionThe neural correlates of episodic memory processes can be assessed in large and standardized cohorts of patients at risk for Alzheimer's disease. Their relation to pathophysiological markers of Alzheimer's disease remains to be studied.
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