基于脉宽调制的MIMO合成切换开关的计算机仿真反馈控制
In-silico Feedback Control of a MIMO Synthetic Toggle Switch via Pulse-Width Modulation
AI总结：
本文研究了通过脉宽调制调整输入占空比，利用基于模型的混合PI-PWM方法和零平均动力学（ZAD）控制器对MIMO合成切换开关进行反馈控制，通过确定性和随机性仿真验证了两种策略的优劣。
摘要：
合成切换开关，最初由Gardner和Collins [1] 提出，是一种可以利用两种诱导分子aTc和IPTG的浓度变化来实现所期望的基因表达水平的MIMO控制系统。已证明[2]可以通过开环外部控制策略实现，其中两个输入被选为互斥的周期脉冲波，具有适当的幅度和占空比。在本文中，我们利用最近推导出的受这些输入影响的基因切换开关的平均模型，合成新的反馈控制方法，通过两种不同的策略实时调整输入的占空比，即基于模型的混合PI-PWM方法和所谓的零平均动力学（ZAD）控制器。这些控制器通过确定性和随机性仿真（SSA）进行计算机仿真验证，展示了每种策略的优势和局限性。
英文摘要：
The synthetic toggle switch, first proposed by Gardner & Collins [1] is a MIMO control system that can be controlled by varying the concentrations of two inducer molecules, aTc and IPTG, to achieve a desired level of expression of the two genes it comprises. It has been shown [2] that this can be accomplished through an open-loop external control strategy where the two inputs are selected as mutually exclusive periodic pulse waves of appropriate amplitude and duty-cycle. In this paper, we use a recently derived average model of the genetic toggle switch subject to these inputs to synthesize new feedback control approaches that adjust the inputs duty-cycle in real-time via two different possible strategies, a model based hybrid PI-PWM approach and a so-called Zero-Average dynamics (ZAD) controller. The controllers are validated in-silico via both deterministic and stochastic simulations (SSA) illustrating the advantages and limitations of each strategy
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
