小鼠脑中尺度连接体的拓扑结构
Topology of the mesoscale connectome of the mouse brain
摘要：
小鼠大脑的接线图最近在艾伦小鼠大脑连接地图集中以介观尺度绘制。使用绿色荧光蛋白追踪来自大脑区域的轴突投射。所得到的数据被配准到一个共同的三维参考空间。他们得出了213个大脑区域之间的连接强度矩阵。全局特征，例如由相似强度的连接形成的闭合环，可以使用持久同源性的工具来推断。我们将小鼠大脑的接线图映射到单纯复合体（通过连接强度过滤）。我们求出了第一个同调群的生成元。有些区域，包括脑桥核，通过回路连接到整个大脑，而没有一个区域与所有大脑区域的连接强度为非零。成千上万的回路穿过同皮质，纹状体和丘脑。另一方面，髓质是唯一包含超过100个回路的主要脑区室。
英文摘要：
The wiring diagram of the mouse brain has recently been mapped at a mesoscopic scale in the Allen Mouse Brain Connectivity Atlas. Axonal projections from brain regions were traced using green fluoresent proteins. The resulting data were registered to a common three-dimensional reference space. They yielded a matrix of connection strengths between 213 brain regions. Global features such as closed loops formed by connections of similar intensity can be inferred using tools from persistent homology. We map the wiring diagram of the mouse brain to a simplicial complex (filtered by connection strengths). We work out generators of the first homology group. Some regions, including nucleus accumbens, are connected to the entire brain by loops, whereas no region has non-zero connection strength to all brain regions. Thousands of loops go through the isocortex, the striatum and the thalamus. On the other hand, medulla is the only major brain compartment that contains more than 100 loops.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
