复发性抑郁症发作期和缓解期EEG复杂性的非线性分析
Nonlinear analysis of EEG complexity in episode and remission phase of recurrent depression
摘要：
长期以来，人们一直在寻找重度抑郁症（MDD）、其阶段和形式的生物标志物。研究表明，皮层电活动（EEG）的复杂性措施可能是这个角色的候选人。目的：研究Higuchi分形维数（HFD）和样本熵（SampEn）测量的脑电活动复杂性在健康受试者、抑郁症缓解期和发作期患者之间是否存在差异，以及这些变化在大脑半球和皮层区域之间是否存在差异。本文记录了26例复发性抑郁症患者和20例年龄、性别相匹配的健康对照者的闭眼静息状态脑电图。通过运行HFD和SampEn算法的内部开发程序分析无伪影EEG时期。与健康受试者相比，抑郁患者具有更高的HFD和SampEn复杂性。令人惊讶的是，缓解期患者的复杂性甚至高于发作期患者。与对照组相比，额叶和中央顶叶区域的复杂性有所改变。抑郁症的两个阶段的额叶和顶叶区域的复杂性不同。SampEn在某些皮层区域表现出比HFD更高的灵敏度。EEG的复杂性测量区分三组。需要进一步的研究来确定这些措施是否有可能帮助临床上做出与抑郁症相关的决定。
英文摘要：
Biomarkers of Major Depressive Disorder(MDD), its phases and forms have long been sought. Research indicates that the complexity measures of the cortical electrical activity (EEG) might be candidates for this role. To examine whether the complexity of EEG activity, measured by Higuchi fractal dimension (HFD) and sample entropy (SampEn), differs between healthy subjects, patients in remission and episode phase of the recurrent depression and whether the changes are differentially distributed between hemispheres and cortical regions. Resting state EEG with eyes closed was recorded from 26 patients suffering from recurrent depression and 20 age and sex-matched healthy control subjects. Artefact-free EEG epochs were analyzed by in-house developed programs running HFD and SampEn algorithms. Depressed patients had higher HFD and SampEn complexity compared to healthy subjects. Surprisingly, the complexity was even higher in patients who were in remission than in those in the episode. Altered complexity was present in the frontal and centro-parietal regions when compared to the control group. The complexity in frontal and parietal regions differed between the two phases of depressive disorder. SampEn manifested higher sensitivity than HFD in some cortical areas. Complexity measures of EEG distinguish between the three groups. Further studies are needed to establish whether these measures carry the potential to aid clinically relevant decisions about depression.
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