适应性细胞中集体振荡的出现
Emergence of collective oscillations in adaptive cells
摘要：
群体中细胞的集体振荡已经在不同的生物学背景下和具有非常不同的分子构建体的情况下被报道。在机械或电气系统中，是否存在与支配自发振荡的原理类似的共同原理？在这里，我们通过对单个细胞对时变信号的响应进行分类来肯定地回答这个问题。需要来自参与细胞的足够增益的正细胞内信号中继来维持振荡，以及相位匹配。这两个条件产生定量预测的发病细胞密度和频率方面测得的单细胞和信号响应函数。通过数学构造，我们表明，细胞，适应一个恒定的刺激满足相位的要求，通过开发一个领先的阶段，在一个“活跃”的频率窗口，使细胞信号的能量流。在几个细胞系统中的动态群体感应的分析与日益增加的生物复杂性重申了关键作用的适应供电振荡，否则耗散细胞间的通信渠道。所确定的物理条件可用于设计综合振荡系统
英文摘要：
Collective oscillation of cells in a population has been reported under diverse biological contexts and with vastly different molecular constructs. Could there be common principles similar to those that govern spontaneous oscillation in mechanical or electrical systems? Here, we answer this question in the affirmative by categorising the response of individual cells against a time-varying signal. A positive intracellular signal relay of sufficient gain from participating cells is required to sustain the oscillations, together with phase matching. The two conditions yield quantitative predictions for the onset cell density and frequency in terms of measured single-cell and signal response functions. Through mathematical constructions, we show that cells that adapt to a constant stimulus fulfil the phase requirement by developing a leading phase in an "active" frequency window that enables cell-to-signal energy flow. Analysis of dynamical quorum sensing in several cellular systems with increasing biological complexity reaffirms the pivotal role of adaptation in powering oscillations in an otherwise dissipative cell-to-cell communication channel. The physical conditions identified can be used to design synthetic oscillatory systems
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