各向异性应力作用下上皮细胞内的多细胞肌动球蛋白缆
Multicellular actomyosin cables in epithelia under external anisotropic stress
摘要：
细胞-细胞连接和相关的皮质肌动球蛋白跨多个细胞排列以在上皮中形成细胞外缆线是驱动形态发生的长程组织组织结构的一个例子。在这里，我们证明了组织组装这些平行电缆的能力取决于上皮细胞的初始包装拓扑结构。使用计算的顶点模型，我们开发了两种方法来测量一个无序的组织的可折叠性，形成电缆下的外部应力。这些测量量化了细胞的变形和应力下组织中的张力分布。使用这些措施，我们表明，被动应力诱导的细胞流动降低了组织的能力，形成电缆，而定向分裂创建一个包装，可以维持多个平行电缆。这些措施适用于一个地区的果蝇展示了转向更电缆友好的包装后，在该地区的一波定向师。
英文摘要：
The alignment of cell-cell junctions and associated cortical actomyosin across multiple cells to form supracellular cables in an epithelium is an example of the long range tissue organization that drives morphogenesis. Here we demonstrate that the ability of tissues to assemble these parallel cables depends on the initial packing topology of the cells in the epithelium. Using a computational vertex model we develop two methods of measuring a disordered tissue's favorability to forming cables under an external stress. These measures quantify the deformation of cells and the distribution of tension in the tissue under stress. Using these measures we show that passive stress-induced cell flow reduces a tissue's ability to form cables, whereas oriented divisions create a packing which can sustain multiple parallel cables. These measures are applied to a region of the the Drosophila demonstrating a shift to a more cable-friendly packing after a wave of oriented divisions in the region.
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