通过快速结合到弹性系链促进运输
Transport Facilitated by Rapid Binding to Elastic Tethers
摘要：
扩散在细胞生物学中是重要而复杂的。扩散粒子在穿过细胞时必须与复杂的环境作斗争。我们分析了一种特殊类型的复杂性，扩散粒子可逆地结合到弹性束缚的结合伙伴时产生的。使用渐近分析，我们推导出有效的方程的单个和多个粒子在这种弹性系绳的存在下的运输。我们发现，对于线性弹性和简单的结合动力学的情况下，弹性系绳有一个弱的阻碍作用时，只有一个粒子的粒子运动，而显着，强烈增强粒子运动时，多个粒子存在。我们对这一结果给出了物理解释，表明类似的效应可能存在于其他生物环境中。
英文摘要：
Diffusion in cell biology is important and complicated. Diffusing particles must contend with a complex environment as they make their way through the cell. We analyze a particular type of complexity that arises when diffusing particles reversibly bind to elastically tethered binding partners. Using asymptotic analysis, we derive effective equations for the transport of both single and multiple particles in the presence of such elastic tethers. We show that for the case of linear elasticity and simple binding kinetics, the elastic tethers have a weak hindering effect on particle motion when only one particle is present, while, remarkably, strongly enhancing particle motion when multiple particles are present. We give a physical interpretation of this result that suggests a similar effect may be present in other biological settings.
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