The ability to generate synthetic medical images is useful for data augmentation, domain transfer, and out-of-distribution detection. However, generating realistic, high-resolution medical images is challenging, particularly for Full Field Digital Mammograms (FFDM), due to the textural heterogeneity, fine structural details and specific tissue properties. In this paper, we explore the use of progressively trained generative adversarial networks (GANs) to synthesize mammograms, overcoming the underlying instabilities when training such adversarial models. This work is the first to show that generation of realistic synthetic medical images is feasible at up to 1280x1024 pixels, the highest resolution achieved for medical image synthesis, enabling visualizations within standard mammographic hanging protocols. We hope this work can serve as a useful guide and facilitate further research on GANs in the medical imaging domain.
Medical University of Gdansk（格但斯克医科大学）；Karolinska University Hospital（卡罗林斯卡大学医院）；Karolinska Institutet（卡罗林斯卡学院）
Computer-aided detection systems based on deep learning have shown good performance in breast cancer detection. However, high-density breasts show poorer detection performance since dense tissues can mask or even simulate masses. Therefore, the sensitivity of mammography for breast cancer detection can be reduced by more than 20% in dense breasts. Additionally, extremely dense cases reported an increased risk of cancer compared to low-density breasts. This study aims to improve the mass detection performance in highdensity breasts using synthetic high-density full-field digital mammograms (FFD…
Mainstream deep models for three-dimensional MRI synthesis are either cross-sectional or volumetric depending on the input. Cross-sectional models can decrease the model complexity, but they may lead to discontinuity artifacts. On the other hand, volumetric models can alleviate the discontinuity artifacts, but they might suffer from loss of spatial resolution due to increased model complexity coupled with scarce training data. To mitigate the limitations of both approaches, we propose a novel model that progressively recovers the target volume via simpler synthesis tasks across individual orie…
Massachusetts General Hospital（麻省总医院）；Casey Eye Institute（凯西眼科研究所）；Brigham and Women’s Hospital（布莱根妇女医院）
Generative adversarial networks (GANs) are a class of unsupervised machine learning algorithms that can produce realistic images from randomly-sampled vectors in a multi-dimensional space. Until recently, it was not possible to generate realistic high-resolution images using GANs, which has limited their applicability to medical images that contain biomarkers only detectable at native resolution. Progressive growing of GANs is an approach wherein an image generator is trained to initially synthesize low resolution synthetic images (8x8 pixels), which are then fed to a discriminator that distin…
MAM-E: Mammographic synthetic image generation with diffusion models
Computer Vision and Robotics Institute (ViCOROB), University of Girona（赫罗纳大学计算机视觉与机器人研究所（ViCOROB））；Clínica Girona, Institute of Diagnostic Imaging (IDI) Girona, University of Girona（赫罗纳大学赫罗纳诊所诊断影像研究所（IDI））
FlexWorld: Progressively Expanding 3D Scenes for Flexiable-View Synthesis
Gaoling School of AI, Renmin University of China（中国人民大学高瓴人工智能学院）；Beijing Key Laboratory of Big Data Management and Analysis Methods（大数据管理与分析方法北京市重点实验室）；School of Artificial Intelligence, Beijing Normal University（北京师范大学人工智能学院）；ByteDance Seed（字节跳动Seed）
Pixel synthesis is a promising research paradigm for image generation, which can well exploit pixel-wise prior knowledge for generation. However, existing methods still suffer from excessive memory footprint and computation overhead. In this paper, we propose a progressive pixel synthesis network towards efficient image generation, coined as PixelFolder. Specifically, PixelFolder formulates image generation as a progressive pixel regression problem and synthesizes images via a multi-stage structure, which can greatly reduce the overhead caused by large tensor transformations. In addition, we i…
Adobe Research（奥多比研究院）；Australian National University（澳大利亚国立大学）
Controllable image synthesis with user scribbles is a topic of keen interest in the computer vision community. In this paper, for the first time we study the problem of photorealistic image synthesis from incomplete and primitive human paintings. In particular, we propose a novel approach paint2pix, which learns to predict (and adapt) "what a user wants to draw" from rudimentary brushstroke inputs, by learning a mapping from the manifold of incomplete human paintings to their realistic renderings. When used in conjunction with recent works in autonomous painting agents, we show that paint2pix …
Recently, diffusion models have shown remarkable results in image synthesis by gradually removing noise and amplifying signals. Although the simple generative process surprisingly works well, is this the best way to generate image data? For instance, despite the fact that human perception is more sensitive to the low frequencies of an image, diffusion models themselves do not consider any relative importance of each frequency component. Therefore, to incorporate the inductive bias for image data, we propose a novel generative process that synthesizes images in a coarse-to-fine manner. First, w…
Bosch Center for Artificial Intelligence（博世人工智能中心）
Training of Generative Adversarial Networks (GANs) is notoriously fragile, requiring to maintain a careful balance between the generator and the discriminator in order to perform well. To mitigate this issue we introduce a new regularization technique - progressive augmentation of GANs (PA-GAN). The key idea is to gradually increase the task difficulty of the discriminator by progressively augmenting its input or feature space, thus enabling continuous learning of the generator. We show that the proposed progressive augmentation preserves the original GAN objective, does not compromise the dis…
Shenzhen University（深圳大学）；Guangzhou Medical University（广州医科大学）
Ultrasound (US) is widely accepted in clinic for anatomical structure inspection. However, lacking in resources to practice US scan, novices often struggle to learn the operation skills. Also, in the deep learning era, automated US image analysis is limited by the lack of annotated samples. Efficiently synthesizing realistic, editable and high resolution US images can solve the problems. The task is challenging and previous methods can only partially complete it. In this paper, we devise a new framework for US image synthesis. Particularly, we firstly adopt a sketch generative adversarial netw…
We propose an image synthesis approach that provides stratified navigation in the latent code space. With a tiny amount of partial or very low-resolution image, our approach can consistently out-perform state-of-the-art counterparts in terms of generating the closest sampled image to the ground truth. We achieve this through scale-independent editing while expanding scale-specific diversity. Scale-independence is achieved with a nested scale disentanglement loss. Scale-specific diversity is created by incorporating a progressive diversification constraint. We introduce semantic persistency acr…
Ultrasound (US) imaging is widely used for anatomical structure inspection in clinical diagnosis. The training of new sonographers and deep learning based algorithms for US image analysis usually requires a large amount of data. However, obtaining and labeling large-scale US imaging data are not easy tasks, especially for diseases with low incidence. Realistic US image synthesis can alleviate this problem to a great extent. In this paper, we propose a generative adversarial network (GAN) based image synthesis framework. Our main contributions include: 1) we present the first work that can synt…
We describe a novel method of generating high-resolution real-world images of text where the style and textual content of the images are described parametrically. Our method combines text to image retrieval techniques with progressive growing of Generative Adversarial Networks (PGGANs) to achieve conditional generation of photo-realistic images that reflect specific styles, as well as artifacts seen in real-world images. We demonstrate our method in the context of automotive license plates. We assess the impact of varying the number of training images of each style on the fidelity of the gener…
Simon Fraser University（西蒙弗雷泽大学）；Memorial University of Newfoundland（纽芬兰纪念大学）；University of Guelph（圭尔夫大学）
We introduce BSD-GAN, a novel multi-branch and scale-disentangled training method which enables unconditional Generative Adversarial Networks (GANs) to learn image representations at multiple scales, benefiting a wide range of generation and editing tasks. The key feature of BSD-GAN is that it is trained in multiple branches, progressively covering both the breadth and depth of the network, as resolutions of the training images increase to reveal finer-scale features. Specifically, each noise vector, as input to the generator network of BSD-GAN, is deliberately split into several sub-vectors, …
Huazhong University of Science and Technology（华中科技大学）；Peking University（北京大学）
In this paper, we focus on semantically multi-modal image synthesis (SMIS) task, namely, generating multi-modal images at the semantic level. Previous work seeks to use multiple class-specific generators, constraining its usage in datasets with a small number of classes. We instead propose a novel Group Decreasing Network (GroupDNet) that leverages group convolutions in the generator and progressively decreases the group numbers of the convolutions in the decoder. Consequently, GroupDNet is armed with much more controllability on translating semantic labels to natural images and has plausible …
Simultaneous Dual-View Mammogram Synthesis Using Denoising Diffusion Probabilistic Models
Tecnologico de Monterrey, School of Engineering and Sciences（蒙特雷科技大学工程与科学学院）；School of Engineering, Pontificia Universidad Católica de Chile（智利天主教大学工程学院）；Tecnologico de Monterrey, School of Medicine and Health Sciences（蒙特雷科技大学医学与健康科学学院）
Generating images from natural language is one of the primary applications of recent conditional generative models. Besides testing our ability to model conditional, highly dimensional distributions, text to image synthesis has many exciting and practical applications such as photo editing or computer-aided content creation. Recent progress has been made using Generative Adversarial Networks (GANs). This material starts with a gentle introduction to these topics and discusses the existent state of the art models. Moreover, I propose Wasserstein GAN-CLS, a new model for conditional image genera…
Med-K2N: Flexible K-to-N Modality Translation for Medical Image Synthesis
University of Science and Technology of China（中国科学技术大学）；Suzhou Institute of Biomedical Engineering and Technology（苏州生物医学工程与技术研究所）；Chinese Academy of Sciences（中国科学院）；The Third Affiliated Hospital of Sun Yat-sen University（中山大学第三附属医院）
Technical University of Munich（慕尼黑工业大学）；Snap Research（Snap研究院）
We present Text2Tex, a novel method for generating high-quality textures for 3D meshes from the given text prompts. Our method incorporates inpainting into a pre-trained depth-aware image diffusion model to progressively synthesize high resolution partial textures from multiple viewpoints. To avoid accumulating inconsistent and stretched artifacts across views, we dynamically segment the rendered view into a generation mask, which represents the generation status of each visible texel. This partitioned view representation guides the depth-aware inpainting model to generate and update partial t…
We propose a novel hierarchical approach for text-to-image synthesis by inferring semantic layout. Instead of learning a direct mapping from text to image, our algorithm decomposes the generation process into multiple steps, in which it first constructs a semantic layout from the text by the layout generator and converts the layout to an image by the image generator. The proposed layout generator progressively constructs a semantic layout in a coarse-to-fine manner by generating object bounding boxes and refining each box by estimating object shapes inside the box. The image generator synthesi…
IIDM: Image-to-Image Diffusion Model for Semantic Image Synthesis
School of Artificial Intelligence, Sun Yat-sen University（中山大学人工智能学院）；Key Laboratory of Machine Intelligence and Advanced Computing, China（中国机器智能与先进计算重点实验室）
Conditional image synthesis aims to create an image according to some multi-modal guidance in the forms of textual descriptions, reference images, and image blocks to preserve, as well as their combinations. In this paper, instead of investigating these control signals separately, we propose a new two-stage architecture, M6-UFC, to unify any number of multi-modal controls. In M6-UFC, both the diverse control signals and the synthesized image are uniformly represented as a sequence of discrete tokens to be processed by Transformer. Different from existing two-stage autoregressive approaches suc…
Autoregressive models and their sequential factorization of the data likelihood have recently demonstrated great potential for image representation and synthesis. Nevertheless, they incorporate image context in a linear 1D order by attending only to previously synthesized image patches above or to the left. Not only is this unidirectional, sequential bias of attention unnatural for images as it disregards large parts of a scene until synthesis is almost complete. It also processes the entire image on a single scale, thus ignoring more global contextual information up to the gist of the entire …
Peking University（北京大学）；Institute of Computer Science and Technology（计算机科学技术研究所）
In this work, we present a new framework for the stylization of text-based binary images. First, our method stylizes the stroke-based geometric shape like text, symbols and icons in the target binary image based on an input style image. Second, the composition of the stylized geometric shape and a background image is explored. To accomplish the task, we propose legibility-preserving structure and texture transfer algorithms, which progressively narrow the visual differences between the binary image and the style image. The stylization is then followed by a context-aware layout design algorithm…
University of Tübingen（蒂宾根大学）；Max Planck Institute for Intelligent Systems（马克斯·普朗克智能系统研究所）；Zhejiang University（浙江大学）
State-of-the-art 3D-aware generative models rely on coordinate-based MLPs to parameterize 3D radiance fields. While demonstrating impressive results, querying an MLP for every sample along each ray leads to slow rendering. Therefore, existing approaches often render low-resolution feature maps and process them with an upsampling network to obtain the final image. Albeit efficient, neural rendering often entangles viewpoint and content such that changing the camera pose results in unwanted changes of geometry or appearance. Motivated by recent results in voxel-based novel view synthesis, we inv…
Enhancing Image Generation Fidelity via Progressive Prompts
Institute of Computing Technology, Chinese Academy of Sciences（中国科学院计算技术研究所）；Tsinghua University（清华大学）；Peking university（北京大学）；EaseUS（易我科技）；The Hong Kong University of Science and Technology（香港科技大学）
Generative Adversarial Networks have shown impressive results for the task of object translation, including face-to-face translation. A key component behind the success of recent approaches is the self-consistency loss, which encourages a network to recover the original input image when the output generated for a desired attribute is itself passed through the same network, but with the target attribute inverted. While the self-consistency loss yields photo-realistic results, it can be shown that the input and target domains, supposed to be close, differ substantially. This is empirically found…
We introduce a novel generative autoencoder network model that learns to encode and reconstruct images with high quality and resolution, and supports smooth random sampling from the latent space of the encoder. Generative adversarial networks (GANs) are known for their ability to simulate random high-quality images, but they cannot reconstruct existing images. Previous works have attempted to extend GANs to support such inference but, so far, have not delivered satisfactory high-quality results. Instead, we propose the Progressively Growing Generative Autoencoder (PIONEER) network which achiev…
University of California, Berkeley（加州大学伯克利分校）；Google Research（谷歌研究院）
Coupling the high-fidelity generation capabilities of label-conditional image synthesis methods with the flexibility of unconditional generative models, we propose a semantic bottleneck GAN model for unconditional synthesis of complex scenes. We assume pixel-wise segmentation labels are available during training and use them to learn the scene structure. During inference, our model first synthesizes a realistic segmentation layout from scratch, then synthesizes a realistic scene conditioned on that layout. For the former, we use an unconditional progressive segmentation generation network that…
Facebook AI；Max Planck Institute for Informatics（马克斯·普朗克信息学研究所）；The University of Hong Kong（香港大学）
We propose StyleNeRF, a 3D-aware generative model for photo-realistic high-resolution image synthesis with high multi-view consistency, which can be trained on unstructured 2D images. Existing approaches either cannot synthesize high-resolution images with fine details or yield noticeable 3D-inconsistent artifacts. In addition, many of them lack control over style attributes and explicit 3D camera poses. StyleNeRF integrates the neural radiance field (NeRF) into a style-based generator to tackle the aforementioned challenges, i.e., improving rendering efficiency and 3D consistency for high-res…
