放射外科等中心点位置和扇形持续时间的同时优化
Simultaneous optimization of isocenter locations and sector duration in radiosurgery
摘要：
立体定向放射外科是治疗脑肿瘤的有效技术，其中几种逆计划方法可能是合适的。我们提出了一个整数规划模型，同时扇区持续时间和等中心优化（SDIO）问题的Leksell伽玛刀{ \textregistered }图标{ \texttrademark }（Elekta，斯德哥尔摩，瑞典），以可追踪地纳入治疗时间。我们设计了一个Benders分解方案来解决SDIO问题的最优性。我们的方法的性能进行了评估，使用匿名数据从8个以前治疗的情况下，并获得治疗计划进行比较，对彼此和对临床计划。我们的SDIO模型生成的计划都符合或超过临床指南，同时表现出高度的一致性。
英文摘要：
Stereotactic radiosurgery is an effective technique to treat brain tumors for which several inverse planning methods may be appropriate. We propose an integer programming model to simultaneous sector duration and isocenter optimization (SDIO) problem for Leksell Gamma Knife{\textregistered} Icon{\texttrademark} (Elekta, Stockholm, Sweden) to tractably incorporate treatment time. We devise a Benders decomposition scheme to solve the SDIO problem to optimality. The performances of our approaches are assessed using anonymized data from eight previously treated cases, and obtained treatment plans are compared against each other and against the clinical plans. The plans generated by our SDIO model all meet or exceed clinical guidelines while demonstrating high conformity.
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