活性微管阵列中异时波的出现
Emergence of Metachronal Waves in Active Microtubule Arrays
摘要：
在过去的几年里，低雷诺数流体中微管阵列中自发形成异时波的物理机制一直受到关注，但仍然没有得到很好的理解。我们从第一性原理出发，提出了一个实现流体动力学耦合假设的模型，并利用该模型模拟了驱动蛋白驱动的微管阵列，观察了它们的涌现行为。模拟的结果进行了比较，已知的实验观察桑切斯等人。通过改变参数，我们确定制度中出现的异时波现象，并归类为其他类型的可能微管运动以外的这些制度。
英文摘要：
The physical mechanism behind the spontaneous formation of metachronal waves in microtubule arrays in a low Reynolds number fluid has been of interest for the past several years, yet is still not well understood. We present a model implementing the hydrodynamic coupling hypothesis from first principles, and use this model to simulate kinesin-driven microtubule arrays and observe their emergent behavior. The results of simulations are compared to known experimental observations by Sanchez et al. By varying parameters, we determine regimes in which the metachronal wave phenomenon emerges, and categorize other types of possible microtubule motion outside these regimes.
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