理解离子通道工作机制的量子化物理框架
A quantized physical framework for understanding the working mechanism of ion channels
摘要：
提出了一个量子化的物理框架，称为五锚模型，用于理解离子通道的工作机制。根据该模型的假设，每个锚点都有两个基本的物理原理：电子跃迁引起的极性变化和静电力引起的相互排斥和吸引。因此，许多独特的现象，如快速和缓慢失活，随机门控模式和恒定电导的一个单一的离子通道，电和光刺激（光遗传学），神经传导阻滞和动作电位的产生之间的差异，成为这个物理模型的内在特征。此外，该模型还为我们以前的C-P理论中用于计算电刺激结果的概率方程提供了基础。
英文摘要：
A quantized physical framework, called the five-anchor model, is developed for a general understanding of the working mechanism of ion channels. According to the hypotheses of this model, the following two basic physical principles are assigned to each anchor: the polarity change induced by an electron transition and the mutual repulsion and attraction induced by an electrostatic force. Consequently, many unique phenomena, such as fast and slow inactivation, the stochastic gating pattern and constant conductance of a single ion channel, the difference between electrical and optical stimulation (optogenetics), nerve conduction block and the generation of an action potential, become intrinsic features of this physical model. Moreover, this model also provides a foundation for the probability equation used to calculate the results of electrical stimulation in our previous C-P theory.
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