arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 1805.02411cs.SIcs.LGq-bio.MNstat.AP
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优先考虑网络社区

Prioritizing network communities

Stanford University(斯坦福大学);Chan Zuckerberg Biohub(陈·扎克伯格生物中心)

Marinka Zitnik, Rok Sosic, Jure Leskovec

摘要:

揭示网络中的模块化结构是生物学、物理学和工程学系统的基础。社区发现将候选模块识别为假设,然后需要通过实验来验证,例如在生物实验室中进行诱变。通常只有少数社区可以得到验证,因此必须优先考虑选择哪些社区进行下游实验。在这里,我们开发了CRank,这是一种基于数学原理的方法,用于对网络社区进行优先级排序。CRank有效地评估每个社区的结构特征的鲁棒性和大小,然后将这些特征组合到社区优先级中。CRank可以与任何社区发现方法一起使用。它只需要网络结构提供的信息,不需要任何额外的元数据或标签。然而,当可用时,CRank可以包含特定于域的信息,以进一步提高性能。在许多大型网络上的实验表明,CRank有效地对社区进行了优先级排序,社区优先级提高了近50倍。

英文摘要:

Uncovering modular structure in networks is fundamental for systems in biology, physics, and engineering. Community detection identifies candidate modules as hypotheses, which then need to be validated through experiments, such as mutagenesis in a biological laboratory. Only a few communities can typically be validated, and it is thus important to prioritize which communities to select for downstream experimentation. Here we develop CRank, a mathematically principled approach for prioritizing network communities. CRank efficiently evaluates robustness and magnitude of structural features of each community and then combines these features into the community prioritization. CRank can be used with any community detection method. It needs only information provided by the network structure and does not require any additional metadata or labels. However, when available, CRank can incorporate domain-specific information to further boost performance. Experiments on many large networks show that CRank effectively prioritizes communities, yielding a nearly 50-fold improvement in community prioritization.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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